Adenosylhomocysteinase
Details
- Name
- Adenosylhomocysteinase
- Synonyms
- 3.3.1.1
- AdoHcyase
- PfSAHH
- S-adenosyl-L-homocysteine hydrolase
- Gene Name
- Not Available
- Organism
- Plasmodium falciparum (isolate 3D7)
- Amino acid sequence
>lcl|BSEQ0051459|Adenosylhomocysteinase MVENKSKVKDISLAPFGKMQMEISENEMPGLMRIREEYGKDQPLKNAKITGCLHMTVECA LLIETLQKLGAQIRWCSCNIYSTADYAAAAVSTLENVTVFAWKNETLEEYWWCVESALTW GDGDDNGPDMIVDDGGDATLLVHKGVEYEKLYEEKNILPDPEKAKNEEERCFLTLLKNSI LKNPKKWTNIAKKIIGVSEETTTGVLRLKKMDKQNELLFTAINVNDAVTKQKYDNVYGCR HSLPDGLMRATDFLISGKIVVICGYGDVGKGCASSMKGLGARVYITEIDPICAIQAVMEG FNVVTLDEIVDKGDFFITCTGNVDVIKLEHLLKMKNNAVVGNIGHFDDEIQVNELFNYKG IHIENVKPQVDRITLPNGNKIIVLARGRLLNLGCATGHPAFVMSFSFCNQTFAQLDLWQN KDTNKYENKVYLLPKHLDEKVALYHLKKLNASLTELDDNQCQFLGVNKSGPFKSNEYRY
- Number of residues
- 479
- Molecular Weight
- 53838.54
- Theoretical pI
- Not Available
- GO Classification
- Functionsadenosylhomocysteinase activity / NAD bindingProcessesone-carbon metabolic process / S-adenosylhomocysteine catabolic process / S-adenosylmethionine cycleComponentscytosol
- General Function
- Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
- Specific Function
- Adenosylhomocysteinase activity
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0051460|Adenosylhomocysteinase ATGGTTGAAAATAAGAGTAAGGTCAAAGATATCAGTTTGGCCCCCTTTGGAAAAATGCAG ATGGAAATTTCTGAAAATGAAATGCCGGGATTAATGAGAATAAGAGAAGAATACGGAAAA GATCAACCATTAAAAAATGCTAAAATTACTGGTTGTTTACATATGACTGTTGAATGTGCT TTATTAATTGAGACTTTACAAAAATTAGGAGCTCAGATTAGGTGGTGTTCATGTAATATT TATTCAACAGCTGATTATGCTGCAGCAGCAGTAAGTACATTAGAAAATGTAACGGTTTTT GCTTGGAAAAATGAAACTTTAGAAGAATACTGGTGGTGTGTTGAAAGTGCCCTTACGTGG GGTGATGGAGATGATAATGGTCCAGATATGATTGTAGATGATGGGGGTGATGCAACCTTA TTAGTTCATAAAGGTGTTGAGTATGAAAAATTATATGAAGAGAAAAATATATTACCTGAT CCAGAAAAAGCAAAAAATGAAGAAGAACGATGTTTTCTAACTTTATTAAAAAATTCCATA TTAAAAAATCCAAAGAAATGGACAAATATTGCAAAGAAAATTATAGGTGTATCTGAAGAA ACTACTACAGGAGTATTAAGATTAAAAAAAATGGACAAACAAAATGAATTATTATTTACT GCTATTAATGTAAATGATGCTGTCACTAAACAAAAATATGATAATGTGTATGGATGTAGA CATTCCTTACCTGACGGATTAATGAGAGCTACCGATTTTTTAATATCTGGAAAAATCGTT GTCATATGTGGATATGGTGACGTAGGTAAAGGATGTGCTTCTTCTATGAAAGGTTTAGGT GCAAGAGTATATATAACAGAAATTGATCCCATATGTGCTATACAAGCTGTAATGGAAGGA TTTAATGTTGTTACTTTAGATGAAATTGTAGATAAAGGAGATTTTTTTATTACTTGTACA GGTAATGTTGATGTTATTAAATTAGAACACTTACTTAAAATGAAAAATAATGCTGTTGTT GGAAACATTGGTCATTTTGATGATGAAATACAAGTAAATGAACTTTTTAATTATAAAGGA ATACATATAGAAAATGTAAAACCACAGGTTGATAGAATTACTTTACCTAATGGAAATAAA ATTATTGTTTTAGCTAGAGGGAGATTATTAAATCTAGGATGTGCAACAGGACATCCAGCA TTTGTTATGTCCTTTTCATTTTGTAATCAAACCTTTGCTCAATTAGATTTATGGCAAAAC AAGGATACAAACAAATATGAAAATAAAGTTTATTTGTTACCTAAACATCTTGATGAAAAG GTTGCTCTTTATCATTTGAAAAAATTGAACGCTTCCTTGACAGAATTGGATGACAATCAA TGTCAATTTTTGGGAGTCAACAAAAGTGGTCCCTTTAAGAGTAACGAATACAGATATTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P50250 UniProtKB Entry Name SAHH_PLAF7 - General References
- Creedon KA, Rathod PK, Wellems TE: Plasmodium falciparum S-adenosylhomocysteine hydrolase. cDNA identification, predicted protein sequence, and expression in Escherichia coli. J Biol Chem. 1994 Jun 10;269(23):16364-70. [Article]
- Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan MS, Nene V, Shallom SJ, Suh B, Peterson J, Angiuoli S, Pertea M, Allen J, Selengut J, Haft D, Mather MW, Vaidya AB, Martin DM, Fairlamb AH, Fraunholz MJ, Roos DS, Ralph SA, McFadden GI, Cummings LM, Subramanian GM, Mungall C, Venter JC, Carucci DJ, Hoffman SL, Newbold C, Davis RW, Fraser CM, Barrell B: Genome sequence of the human malaria parasite Plasmodium falciparum. Nature. 2002 Oct 3;419(6906):498-511. [Article]
- Hall N, Pain A, Berriman M, Churcher C, Harris B, Harris D, Mungall K, Bowman S, Atkin R, Baker S, Barron A, Brooks K, Buckee CO, Burrows C, Cherevach I, Chillingworth C, Chillingworth T, Christodoulou Z, Clark L, Clark R, Corton C, Cronin A, Davies R, Davis P, Dear P, Dearden F, Doggett J, Feltwell T, Goble A, Goodhead I, Gwilliam R, Hamlin N, Hance Z, Harper D, Hauser H, Hornsby T, Holroyd S, Horrocks P, Humphray S, Jagels K, James KD, Johnson D, Kerhornou A, Knights A, Konfortov B, Kyes S, Larke N, Lawson D, Lennard N, Line A, Maddison M, McLean J, Mooney P, Moule S, Murphy L, Oliver K, Ormond D, Price C, Quail MA, Rabbinowitsch E, Rajandream MA, Rutter S, Rutherford KM, Sanders M, Simmonds M, Seeger K, Sharp S, Smith R, Squares R, Squares S, Stevens K, Taylor K, Tivey A, Unwin L, Whitehead S, Woodward J, Sulston JE, Craig A, Newbold C, Barrell BG: Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Nature. 2002 Oct 3;419(6906):527-31. [Article]
- Tanaka N, Nakanishi M, Kusakabe Y, Shiraiwa K, Yabe S, Ito Y, Kitade Y, Nakamura KT: Crystal structure of S-adenosyl-L-homocysteine hydrolase from the human malaria parasite Plasmodium falciparum. J Mol Biol. 2004 Oct 29;343(4):1007-17. [Article]