Serpin B9

Details

Name

Serpin B9

Synonyms

• CAP-3
• CAP3
• Cytoplasmic antiproteinase 3
• Peptidase inhibitor 9
• PI-9
• PI9

Gene Name

SERPINB9

Organism

Humans

Amino acid sequence

>lcl|BSEQ0049679|Serpin B9
METLSNASGTFAIRLLKILCQDNPSHNVFCSPVSISSALAMVLLGAKGNTATQMAQALSL
NTEEDIHRAFQSLLTEVNKAGTQYLLRTANRLFGEKTCQFLSTFKESCLQFYHAELKELS
FIRAAEESRKHINTWVSKKTEGKIEELLPGSSIDAETRLVLVNAIYFKGKWNEPFDETYT
REMPFKINQEEQRPVQMMYQEATFKLAHVGEVRAQLLELPYARKELSLLVLLPDDGVELS
TVEKSLTFEKLTAWTKPDCMKSTEVEVLLPKFKLQEDYDMESVLRHLGIVDAFQQGKADL
SAMSAERDLCLSKFVHKSFVEVNEEGTEAAAASSCFVVAECCMESGPRFCADHPFLFFIR
HNRANSILFCGRFSSP

Number of residues

376

Molecular Weight

42403.185

Theoretical pI

Not Available

GO Classification

Functions

cysteine-type endopeptidase inhibitor activity involved in apoptotic process / protease binding / serine-type endopeptidase inhibitor activity

Processes

cellular response to estrogen stimulus / immune response / mast cell mediated immunity / negative regulation by symbiont of host apoptotic process / negative regulation of apoptotic process / negative regulation of endopeptidase activity / positive regulation of gene expression / protection from natural killer cell mediated cytotoxicity / response to bacterium

Components

cytoplasm / cytosol / extracellular exosome / extracellular space / intracellular / membrane / nucleus

General Function

Granzyme B inhibitor.

Specific Function

Cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Pfam Domain Function

• Serpin (PF00079)

Transmembrane Regions

Not Available

Cellular Location

Cytoplasm

Gene sequence

>lcl|BSEQ0049680|Serpin B9 (SERPINB9)
ATGGAAACTCTTTCTAATGCAAGTGGTACTTTTGCCATACGCCTTTTAAAGATACTGTGT
CAAGATAACCCTTCGCACAACGTGTTCTGTTCTCCTGTGAGCATCTCCTCTGCCCTGGCC
ATGGTTCTCCTAGGGGCAAAGGGAAACACCGCAACCCAGATGGCCCAGGCACTGTCTTTA
AACACAGAGGAAGACATTCATCGGGCTTTCCAGTCGCTTCTCACTGAAGTGAACAAGGCT
GGCACACAGTACCTGCTGAGAACGGCCAACAGGCTCTTTGGAGAGAAAACTTGTCAGTTC
CTCTCAACGTTTAAGGAATCCTGTCTTCAATTCTACCATGCTGAGCTGAAGGAGCTTTCC
TTTATCAGAGCTGCAGAAGAGTCCAGGAAACACATCAACACCTGGGTCTCAAAAAAGACC
GAAGGTAAAATTGAAGAGTTGTTGCCGGGTAGCTCAATTGATGCAGAAACCAGGCTGGTT
CTTGTCAATGCCATCTACTTCAAAGGAAAGTGGAATGAACCGTTTGACGAAACATACACA
AGGGAAATGCCCTTTAAAATAAACCAGGAGGAGCAAAGGCCAGTGCAGATGATGTATCAG
GAGGCCACGTTTAAGCTCGCCCACGTGGGCGAGGTGCGCGCGCAGCTGCTGGAGCTGCCC
TACGCCAGGAAGGAGCTGAGCCTGCTGGTGCTGCTGCCTGACGACGGCGTGGAGCTCAGC
ACGGTGGAAAAAAGTCTCACTTTTGAGAAACTCACAGCCTGGACCAAGCCAGACTGTATG
AAGAGTACTGAGGTTGAAGTTCTCCTTCCAAAATTTAAACTACAAGAGGATTATGACATG
GAATCTGTGCTTCGGCATTTGGGAATTGTTGATGCCTTCCAACAGGGCAAGGCTGACTTG
TCGGCAATGTCAGCGGAGAGAGACCTGTGTCTGTCCAAGTTCGTGCACAAGAGTTTTGTG
GAGGTGAATGAAGAAGGCACCGAGGCAGCGGCAGCGTCGAGCTGCTTTGTAGTTGCAGAG
TGCTGCATGGAATCTGGCCCCAGGTTCTGTGCTGACCACCCTTTCCTTTTCTTCATCAGG
CACAACAGAGCCAACAGCATTCTGTTCTGTGGCAGGTTCTCATCGCCATAA

Chromosome Location

6

Locus

6p25.2

External Identifiers

Resource	Link
UniProtKB ID	P50453
UniProtKB Entry Name	SPB9_HUMAN
HGNC ID	HGNC:8955

General References

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2. Sun J, Bird CH, Sutton V, McDonald L, Coughlin PB, De Jong TA, Trapani JA, Bird PI: A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes. J Biol Chem. 1996 Nov 1;271(44):27802-9. [Article]
3. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
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Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB00481	Raloxifene	approved, investigational	unknown		Details