Tubby protein homolog

Details

Name
Tubby protein homolog
Synonyms
Not Available
Gene Name
TUB
Organism
Humans
Amino acid sequence
>lcl|BSEQ0009465|Tubby protein homolog
MTSKPHSDWIPYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRR
ARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQG
GAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQD
LRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAP
EQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLA
GRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLES
GTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTE
SIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTM
DYNYPLCALQAFAIALSSFDSKLACE
Number of residues
506
Molecular Weight
55650.695
Theoretical pI
Not Available
GO Classification
Functions
phosphatidylinositol binding / protein complex binding
Processes
phagocytosis, recognition / photoreceptor cell maintenance / positive regulation of phagocytosis / protein localization to photoreceptor outer segment / receptor localization to nonmotile primary cilium / response to hormone / retina development in camera-type eye / sensory perception of sound
Components
cilium / cytoplasm / cytosol / extracellular region / nucleus / plasma membrane
General Function
Protein complex binding
Specific Function
Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0019589|Tubby protein homolog (TUB)
ATGGGGGCCAGGACACCTTTGCCTTCTTTCTGGGTTTCTTTCTTTGCCGAGACAGGGATT
TTGTTCCCAGGAGGCACTCCCTGGCCCATGGGATCTCAGCATTCAAAGCAGCACAGGAAA
CCTGGGCCCCTGAAACGGGGCCACCGAAGAGATCGGAGAACAACCAGGAGGAAGTACTGG
AAGGAAGGAAGGGAGATCGCTCGTGTCTTAGATGATGAGGGCAGAAACCTGAGGCAGCAG
AAGCTTGATCGGCAGCGGGCCCTGCTGGAGCAGAAGCAGAAGAAGAAGCGCCAGGAGCCC
CTGATGGTGCAGGCCAATGCAGATGGGCGGCCCCGGAGCCGGCGGGCCCGGCAGTCAGAG
GAACAAGCCCCCCTGGTGGAGTCCTACCTCAGCAGCAGTGGCAGCACCAGCTACCAAGTT
CAAGAGGCCGACTCACTCGCCAGTGTGCAGCTGGGAGCCACGCGCCCAACAGCACCAGCT
TCAGCCAAGAGAACCAAGGCGGCAGCTACAGCAGGGGGCCAGGGTGGCGCCGCTAGGAAG
GAGAAGAAGGGAAAGCACAAAGGCACCAGCGGGCCAGCAGCACTGGCAGAAGACAAGTCT
GAGGCCCAAGGCCCAGTGCAGATTCTGACTGTGGGCCAGTCAGACCACGCCCAGGACGCA
GGGGAGACGGCAGCTGGTGGGGGCGAACGGCCCAGCGGGCAGGATCTCCGTGCCACGATG
CAGAGGAAGGGCATCTCCAGCAGCATGAGCTTTGACGAGGATGAGGAGGATGAGGAGGAG
AATAGCTCCAGCTCCTCCCAGCTAAATAGTAACACCCGCCCCAGCTCTGCTACTAGCAGG
AAGTCCGTCAGGGAGGCAGCCTCAGCCCCTAGCCCAACAGCTCCAGAGCAACCAGTGGAC
GTTGAGGTCCAGGATCTTGAGGAGTTTGCACTGAGGCCGGCCCCCCAGGGTATCACCATC
AAATGCCGCATCACTCGGGACAAGAAAGGGATGGACCGGGGCATGTACCCCACCTACTTT
CTGCACCTGGACCGTGAGGATGGGAAGAAGGTGTTCCTCCTGGCGGGAAGGAAGAGAAAG
AAGAGTAAAACTTCCAATTACCTCATCTCTGTGGACCCAACAGACTTGTCTCGAGGAGGG
GACAGCTATATCGGGAAACTGCGGTCCAACTTGATGGGCACCAAGTTCACTGTTTATGAC
AATGGAGTCAACCCTCAGAAGGCCTCATCCTCCACTTTGGAAAGTGGAACCTTACGTCAG
GAGCTGGCAGCTGTGTGCTACGAGACAAACGTCTTAGGCTTCAAGGGGCCTCGGAAGATG
AGCGTGATTGTCCCAGGCATGAACATGGTTCATGAGAGAGTCTCTATCCGCCCCCGCAAC
GAGCATGAGACACTGCTAGCACGCTGGCAGAATAAGAACACGGAGAGTATCATCGAGCTG
CAAAACAAGACACCTGTCTGGAATGATGACACACAGTCCTATGTACTCAACTTCCATGGG
CGCGTCACACAGGCCTCCGTGAAGAACTTCCAGATCATCCATGGCAATGACCCGGACTAC
ATCGTGATGCAGTTTGGCCGGGTAGCAGAGGATGTGTTCACCATGGATTACAACTACCCG
CTGTGTGCACTGCAGGCCTTTGCCATTGCCCTGTCCAGCTTCGACAGCAAGCTGGCGTGC
GAGTAG
Chromosome Location
11
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP50607
UniProtKB Entry NameTUB_HUMAN
HGNC IDHGNC:12406
General References
  1. Kleyn PW, Fan W, Kovats SG, Lee JJ, Pulido JC, Wu Y, Berkemeier LR, Misumi DJ, Holmgren L, Charlat O, Woolf EA, Tayber O, Brody T, Shu P, Hawkins F, Kennedy B, Baldini L, Ebeling C, Alperin GD, Deeds J, Lakey ND, Culpepper J, Chen H, Glucksmann-Kuis MA, Carlson GA, Duyk GM, Moore KJ: Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family. Cell. 1996 Apr 19;85(2):281-90. [Article]
  2. North MA, Naggert JK, Yan Y, Noben-Trauth K, Nishina PM: Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3128-33. [Article]
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  4. Caberoy NB, Maiguel D, Kim Y, Li W: Identification of tubby and tubby-like protein 1 as eat-me signals by phage display. Exp Cell Res. 2010 Jan 15;316(2):245-57. doi: 10.1016/j.yexcr.2009.10.008. Epub 2009 Oct 22. [Article]
  5. Borman AD, Pearce LR, Mackay DS, Nagel-Wolfrum K, Davidson AE, Henderson R, Garg S, Waseem NH, Webster AR, Plagnol V, Wolfrum U, Farooqi IS, Moore AT: A homozygous mutation in the TUB gene associated with retinal dystrophy and obesity. Hum Mutat. 2014 Mar;35(3):289-93. doi: 10.1002/humu.22482. Epub 2013 Dec 20. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB02028(1R,2R,3S,4R,6S)-3,4,6-Trihydroxy-5-{[(S)-hydroxy(3-hydroxy-2-oxopropoxy)phosphoryl]oxy}-1,2-cyclohexanediyl bis[dihydrogen (phosphate)]experimentalunknownDetails