Tubby protein homolog
Details
- Name
- Tubby protein homolog
- Synonyms
- Not Available
- Gene Name
- TUB
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009465|Tubby protein homolog MTSKPHSDWIPYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRR ARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQG GAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQD LRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAP EQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLA GRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLES GTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTE SIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTM DYNYPLCALQAFAIALSSFDSKLACE
- Number of residues
- 506
- Molecular Weight
- 55650.695
- Theoretical pI
- Not Available
- GO Classification
- Functionsphosphatidylinositol binding / protein complex bindingProcessesphagocytosis, recognition / photoreceptor cell maintenance / positive regulation of phagocytosis / protein localization to photoreceptor outer segment / receptor localization to nonmotile primary cilium / response to hormone / retina development in camera-type eye / sensory perception of soundComponentscilium / cytoplasm / cytosol / extracellular region / nucleus / plasma membrane
- General Function
- Protein complex binding
- Specific Function
- Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0019589|Tubby protein homolog (TUB) ATGGGGGCCAGGACACCTTTGCCTTCTTTCTGGGTTTCTTTCTTTGCCGAGACAGGGATT TTGTTCCCAGGAGGCACTCCCTGGCCCATGGGATCTCAGCATTCAAAGCAGCACAGGAAA CCTGGGCCCCTGAAACGGGGCCACCGAAGAGATCGGAGAACAACCAGGAGGAAGTACTGG AAGGAAGGAAGGGAGATCGCTCGTGTCTTAGATGATGAGGGCAGAAACCTGAGGCAGCAG AAGCTTGATCGGCAGCGGGCCCTGCTGGAGCAGAAGCAGAAGAAGAAGCGCCAGGAGCCC CTGATGGTGCAGGCCAATGCAGATGGGCGGCCCCGGAGCCGGCGGGCCCGGCAGTCAGAG GAACAAGCCCCCCTGGTGGAGTCCTACCTCAGCAGCAGTGGCAGCACCAGCTACCAAGTT CAAGAGGCCGACTCACTCGCCAGTGTGCAGCTGGGAGCCACGCGCCCAACAGCACCAGCT TCAGCCAAGAGAACCAAGGCGGCAGCTACAGCAGGGGGCCAGGGTGGCGCCGCTAGGAAG GAGAAGAAGGGAAAGCACAAAGGCACCAGCGGGCCAGCAGCACTGGCAGAAGACAAGTCT GAGGCCCAAGGCCCAGTGCAGATTCTGACTGTGGGCCAGTCAGACCACGCCCAGGACGCA GGGGAGACGGCAGCTGGTGGGGGCGAACGGCCCAGCGGGCAGGATCTCCGTGCCACGATG CAGAGGAAGGGCATCTCCAGCAGCATGAGCTTTGACGAGGATGAGGAGGATGAGGAGGAG AATAGCTCCAGCTCCTCCCAGCTAAATAGTAACACCCGCCCCAGCTCTGCTACTAGCAGG AAGTCCGTCAGGGAGGCAGCCTCAGCCCCTAGCCCAACAGCTCCAGAGCAACCAGTGGAC GTTGAGGTCCAGGATCTTGAGGAGTTTGCACTGAGGCCGGCCCCCCAGGGTATCACCATC AAATGCCGCATCACTCGGGACAAGAAAGGGATGGACCGGGGCATGTACCCCACCTACTTT CTGCACCTGGACCGTGAGGATGGGAAGAAGGTGTTCCTCCTGGCGGGAAGGAAGAGAAAG AAGAGTAAAACTTCCAATTACCTCATCTCTGTGGACCCAACAGACTTGTCTCGAGGAGGG GACAGCTATATCGGGAAACTGCGGTCCAACTTGATGGGCACCAAGTTCACTGTTTATGAC AATGGAGTCAACCCTCAGAAGGCCTCATCCTCCACTTTGGAAAGTGGAACCTTACGTCAG GAGCTGGCAGCTGTGTGCTACGAGACAAACGTCTTAGGCTTCAAGGGGCCTCGGAAGATG AGCGTGATTGTCCCAGGCATGAACATGGTTCATGAGAGAGTCTCTATCCGCCCCCGCAAC GAGCATGAGACACTGCTAGCACGCTGGCAGAATAAGAACACGGAGAGTATCATCGAGCTG CAAAACAAGACACCTGTCTGGAATGATGACACACAGTCCTATGTACTCAACTTCCATGGG CGCGTCACACAGGCCTCCGTGAAGAACTTCCAGATCATCCATGGCAATGACCCGGACTAC ATCGTGATGCAGTTTGGCCGGGTAGCAGAGGATGTGTTCACCATGGATTACAACTACCCG CTGTGTGCACTGCAGGCCTTTGCCATTGCCCTGTCCAGCTTCGACAGCAAGCTGGCGTGC GAGTAG
- Chromosome Location
- 11
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P50607 UniProtKB Entry Name TUB_HUMAN HGNC ID HGNC:12406 - General References
- Kleyn PW, Fan W, Kovats SG, Lee JJ, Pulido JC, Wu Y, Berkemeier LR, Misumi DJ, Holmgren L, Charlat O, Woolf EA, Tayber O, Brody T, Shu P, Hawkins F, Kennedy B, Baldini L, Ebeling C, Alperin GD, Deeds J, Lakey ND, Culpepper J, Chen H, Glucksmann-Kuis MA, Carlson GA, Duyk GM, Moore KJ: Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family. Cell. 1996 Apr 19;85(2):281-90. [Article]
- North MA, Naggert JK, Yan Y, Noben-Trauth K, Nishina PM: Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3128-33. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Caberoy NB, Maiguel D, Kim Y, Li W: Identification of tubby and tubby-like protein 1 as eat-me signals by phage display. Exp Cell Res. 2010 Jan 15;316(2):245-57. doi: 10.1016/j.yexcr.2009.10.008. Epub 2009 Oct 22. [Article]
- Borman AD, Pearce LR, Mackay DS, Nagel-Wolfrum K, Davidson AE, Henderson R, Garg S, Waseem NH, Webster AR, Plagnol V, Wolfrum U, Farooqi IS, Moore AT: A homozygous mutation in the TUB gene associated with retinal dystrophy and obesity. Hum Mutat. 2014 Mar;35(3):289-93. doi: 10.1002/humu.22482. Epub 2013 Dec 20. [Article]