Cyclin-dependent kinase 7

Details

Name
Cyclin-dependent kinase 7
Synonyms
  • 2.7.11.22
  • 39 kDa protein kinase
  • CAK
  • CAK1
  • CDK-activating kinase 1
  • CDKN7
  • Cell division protein kinase 7
  • MO15
  • p39 Mo15
  • Serine/threonine-protein kinase 1
  • STK1
  • TFIIH basal transcription factor complex kinase subunit
Gene Name
CDK7
Organism
Humans
Amino acid sequence
>lcl|BSEQ0021853|Cyclin-dependent kinase 7
MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL
REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM
TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA
PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM
CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG
PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
Number of residues
346
Molecular Weight
39038.005
Theoretical pI
8.68
GO Classification
Functions
androgen receptor binding / ATP binding / cyclin-dependent protein serine/threonine kinase activity / DNA-dependent ATPase activity / protein C-terminus binding / protein kinase activity / RNA polymerase II carboxy-terminal domain kinase activity / transcription coactivator activity
Processes
7-methylguanosine mRNA capping / androgen receptor signaling pathway / cell cycle arrest / cell division / cell proliferation / DNA repair / G1/S transition of mitotic cell cycle / G2/M transition of mitotic cell cycle / gene expression / global genome nucleotide-excision repair / mitotic cell cycle / negative regulation of gene expression, epigenetic / nucleotide-excision repair / positive regulation of transcription from RNA polymerase II promoter / positive regulation of transcription, DNA-templated / positive regulation of viral transcription / regulation of cyclin-dependent protein serine/threonine kinase activity / regulation of gene expression, epigenetic / termination of RNA polymerase I transcription / transcription elongation from RNA polymerase I promoter / transcription elongation from RNA polymerase II promoter / transcription from RNA polymerase I promoter / transcription from RNA polymerase II promoter / transcription initiation from RNA polymerase I promoter / transcription initiation from RNA polymerase II promoter / transcription-coupled nucleotide-excision repair / viral process
Components
cytoplasm / holo TFIIH complex / mitochondrion / nucleoplasm / nucleus / perinuclear region of cytoplasm
General Function
Transcription coactivator activity
Specific Function
Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0021854|Cyclin-dependent kinase 7 (CDK7)
ATGGCTCTGGACGTGAAGTCTCGGGCAAAGCGTTATGAGAAGCTGGACTTCCTTGGGGAG
GGACAGTTTGCCACCGTTTACAAGGCCAGAGATAAGAACACCAACCAAATTGTCGCCATT
AAGAAAATCAAACTTGGACATAGATCAGAAGCTAAAGATGGTATAAATAGAACCGCCTTA
AGAGAGATAAAATTATTACAGGAGCTAAGTCATCCAAATATAATTGGTCTCCTTGATGCT
TTTGGACATAAATCTAATATTAGCCTTGTCTTTGATTTTATGGAAACTGATCTAGAGGTT
ATAATAAAGGATAATAGTCTTGTGCTGACACCATCACACATCAAAGCCTACATGTTGATG
ACTCTTCAAGGATTAGAATATTTACATCAACATTGGATCCTACATAGGGATCTGAAACCA
AACAACTTGTTGCTAGATGAAAATGGAGTTCTAAAACTGGCAGATTTTGGCCTGGCCAAA
TCTTTTGGGAGCCCCAATAGAGCTTATACACATCAGGTTGTAACCAGGTGGTATCGGGCC
CCCGAGTTACTATTTGGAGCTAGGATGTATGGTGTAGGTGTGGACATGTGGGCTGTTGGC
TGTATATTAGCAGAGTTACTTCTAAGGGTTCCTTTTTTGCCAGGAGATTCAGACCTTGAT
CAGCTAACAAGAATATTTGAAACTTTGGGCACACCAACTGAGGAACAGTGGCCGGACATG
TGTAGTCTTCCAGATTATGTGACATTTAAGAGTTTCCCTGGAATACCTTTGCATCACATC
TTCAGTGCAGCAGGAGACGACTTACTAGATCTCATACAAGGCTTATTCTTATTTAATCCA
TGTGCTCGAATTACGGCCACACAGGCACTGAAAATGAAGTATTTCAGTAATCGGCCAGGG
CCAACACCTGGATGTCAGCTGCCAAGACCAAACTGTCCAGTGGAAACCTTAAAGGAGCAA
TCAAATCCAGCTTTGGCAATAAAAAGGAAAAGAACAGAGGCCTTAGAACAAGGAGGATTG
CCCAAGAAACTAATTTTTTAA
Chromosome Location
5
Locus
5q12.1
External Identifiers
ResourceLink
UniProtKB IDP50613
UniProtKB Entry NameCDK7_HUMAN
GenBank Protein ID485909
GenBank Gene IDX79193
GenAtlas IDCDK7
HGNC IDHGNC:1778
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB02482PhosphonothreonineexperimentalunknownDetails
DB03496Alvocidibexperimental, investigationalunknownDetails
DB05969SNS-032investigationalunknownDetails
DB06195SeliciclibinvestigationalunknownDetails