Multidrug resistance protein MexB
Details
- Name
- Multidrug resistance protein MexB
- Synonyms
- Multidrug-efflux transporter MexB
- Gene Name
- mexB
- Organism
- Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
- Amino acid sequence
>lcl|BSEQ0052193|Multidrug resistance protein MexB MSKFFIDRPIFAWVIALVIMLAGGLSILSLPVNQYPAIAPPAIAVQVSYPGASAETVQDT VVQVIEQQMNGIDNLRYISSESNSDGSMTITVTFEQGTDPDIAQVQVQNKLQLATPLLPQ EVQRQGIRVTKAVKNFLMVVGVVSTDGSMTKEDLSNYIVSNIQDPLSRTKGVGDFQVFGS QYSMRIWLDPAKLNSYQLTPGDVSSAIQAQNVQISSGQLGGLPAVKGQQLNATIIGKTRL QTAEQFENILLKVNPDGSQVRLKDVADVGLGGQDYSINAQFNGSPASGIAIKLATGANAL DTAKAIRQTIANLEPFMPQGMKVVYPYDTTPVVSASIHEVVKTLGEAILLVFLVMYLFLQ NFRATLIPTIAVPVVLLGTFGVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVM AEEGLSPREAARKSMGQIQGALVGIAMVLSAVFLPMAFFGGSTGVIYRQFSITIVSAMAL SVIVALILTPALCATMLKPIEKGDHGEHKGGFFGWFNRMFLSTTHGYERGVASILKHRAP YLLIYVVIVAGMIWMFTRIPTAFLPDEDQGVLFAQVQTPPGSSAERTQVVVDSMREYLLE KESSSVSSVFTVTGFNFAGRGQSSGMAFIMLKPWEERPGGENSVFELAKRAQMHFFSFKD AMVFAFAPPSVLELGNATGFDLFLQDQAGVGHEVLLQARNKFLMLAAQNPALQRVRPNGM SDEPQYKLEIDDEKASALGVSLADINSTVSIAWGSSYVNDFIDRGRVKRVYLQGRPDARM NPDDLSKWYVRNDKGEMVPFNAFATGKWEYGSPKLERYNGVPAMEILGEPAPGLSSGDAM AAVEEIVKQLPKGVGYSWTGLSYEERLSGSQAPALYALSLLVVFLCLAALYESWSIPFSV MLVVPLGVIGALLATSMRGLSNDVFFQVGLLTTIGLSAKNAILIVEFAKELHEQGKGIVE AAIEACRMRLRPIVMTSLAFILGVVPLAISTGAGSGSQHAIGTGVIGGMVTATVLAIFWV PLFYVAVSTLFKDEASKQQASVEKGQ
- Number of residues
- 1046
- Molecular Weight
- 112789.735
- Theoretical pI
- Not Available
- GO Classification
- Functionsefflux transmembrane transporter activity / xenobiotic transmembrane transporter activityProcessesresponse to antibioticComponentsintegral component of membrane / plasma membrane
- General Function
- The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine.
- Specific Function
- Efflux transmembrane transporter activity
- Pfam Domain Function
- ACR_tran (PF00873)
- Transmembrane Regions
- 10-28 340-359 366-385 392-413 442-460 474-496 539-557 872-891 898-917 924-945 973-991 1005-1027
- Cellular Location
- Cell inner membrane
- Gene sequence
>lcl|BSEQ0052194|Multidrug resistance protein MexB (mexB) ATGTCGAAGTTTTTCATTGATAGGCCCATTTTCGCGTGGGTGATCGCCTTGGTGATCATG CTCGCGGGCGGCCTGTCGATCCTCAGTCTGCCGGTCAACCAGTACCCGGCCATCGCCCCG CCGGCCATCGCCGTGCAGGTGAGCTACCCGGGCGCCTCGGCCGAGACGGTGCAGGACACC GTGGTCCAGGTGATCGAGCAGCAGATGAACGGGATCGACAATCTGCGCTACATCTCCTCG GAGAGTAACTCCGACGGCAGCATGACCATCACCGTGACCTTCGAACAGGGCACCGACCCC GACATCGCCCAGGTCCAGGTGCAGAACAAGCTGCAACTGGCCACCCCGCTACTGCCGCAG GAAGTGCAGCGCCAGGGGATCCGGGTGACCAAGGCGGTGAAGAACTTCCTCATGGTGGTC GGTGTGGTTTCCACCGACGGCAGCATGACCAAGGAAGACCTGTCGAACTACATCGTTTCC AACATCCAGGACCCACTCTCGCGGACCAAGGGCGTCGGTGACTTCCAGGTGTTCGGCTCG CAGTACTCGATGCGCATCTGGCTCGACCCGGCCAAGCTGAACAGCTACCAGCTGACCCCC GGCGACGTGAGCAGCGCGATCCAGGCGCAGAACGTGCAGATTTCCTCCGGCCAGCTCGGC GGCTTGCCGGCGGTCAAGGGCCAGCAGCTCAACGCCACCATCATCGGCAAGACCCGCCTG CAGACCGCGGAGCAATTCGAGAACATCCTGCTCAAGGTCAATCCCGACGGTTCCCAGGTG CGCCTGAAGGACGTCGCCGATGTAGGCCTGGGCGGCCAGGACTACAGCATCAACGCGCAG TTCAACGGCAGCCCGGCGTCCGGTATCGCGATCAAGCTGGCCACCGGCGCCAACGCGCTG GATACCGCCAAGGCGATCCGCCAGACCATCGCCAACCTGGAACCGTTCATGCCGCAGGGC ATGAAGGTGGTCTACCCGTACGACACCACCCCGGTGGTCTCGGCCTCGATCCATGAGGTA GTGAAGACCCTCGGCGAGGCGATCCTCCTCGTGTTCCTGGTGATGTACCTGTTCCTGCAG AACTTCCGCGCCACGCTGATCCCGACCATCGCCGTACCGGTGGTGCTGCTGGGGACCTTC GGCGTGCTCGCCGCGTTCGGCTTCTCGATCAACACCCTGACCATGTTCGGCATGGTGCTG GCCATCGGCTTGCTGGTGGACGACGCCATCGTGGTGGTGGAGAACGTCGAGCGGGTGATG GCCGAGGAAGGCCTGTCGCCAAGGGAGGCGGCGCGCAAGTCCATGGGCCAGATCCAGGGC GCGCTGGTCGGTATCGCCATGGTGCTCTCGGCGGTATTCCTGCCGATGGCGTTCTTCGGC GGCTCCACCGGGGTGATCTACCGGCAGTTCTCCATCACCATCGTGTCGGCCATGGCCCTC TCGGTGATCGTGGCGCTGATCCTCACCCCGGCGCTCTGCGCGACCATGCTCAAGCCGATC GAGAAAGGCGACCATGGCGAGCACAAGGGCGGCTTCTTCGGCTGGTTCAACCGGATGTTC CTTTCCACCACCCACGGCTACGAGCGGGGCGTGGCGTCGATCCTCAAGCATCGCGCGCCG TACCTGCTGATCTACGTGGTGATCGTGGCCGGGATGATCTGGATGTTCACCCGCATTCCC ACCGCGTTCCTCCCCGACGAGGACCAGGGCGTACTGTTCGCCCAGGTACAGACCCCGCCG GGCTCCAGTGCCGAGCGTACCCAGGTGGTGGTGGACTCGATGCGCGAATACCTGCTGGAG AAGGAAAGCTCTTCGGTCAGCTCGGTGTTCACCGTGACCGGCTTCAACTTCGCCGGCCGC GGCCAGAGTTCGGGCATGGCGTTCATCATGCTCAAGCCCTGGGAAGAGCGTCCCGGTGGC GAGAACAGCGTGTTCGAACTGGCCAAGCGCGCGCAGATGCACTTCTTCAGCTTCAAGGAC GCGATGGTGTTCGCCTTCGCGCCGCCGTCGGTACTGGAACTGGGTAACGCCACCGGCTTC GACCTGTTCCTCCAGGACCAGGCGGGTGTCGGCCACGAAGTCCTGCTCCAGGCGCGCAAC AAGTTCCTCATGCTCGCCGCGCAGAACCCGGCGCTGCAACGCGTGCGCCCCAACGGCATG AGCGACGAACCGCAGTACAAGCTGGAGATCGACGACGAGAAGGCCAGCGCCCTCGGCGTG TCCCTTGCCGACATCAACAGCACCGTGTCCATCGCCTGGGGTTCCAGCTACGTCAACGAT TTCATCGACCGTGGCCGGGTCAAGCGGGTCTACCTGCAGGGCAGGCCGGACGCGCGGATG AACCCGGACGACCTGAGCAAGTGGTACGTGCGCAACGACAAGGGCGAGATGGTGCCGTTC AACGCCTTCGCCACCGGCAAGTGGGAATACGGTTCGCCGAAGCTGGAGCGCTACAATGGC GTGCCGGCGATGGAGATCCTCGGCGAGCCGGCGCCCGGCCTGAGTTCCGGTGACGCCATG GCGGCGGTCGAGGAGATCGTCAAGCAATTGCCGAAAGGCGTTGGCTACTCCTGGACCGGC CTGTCCTACGAGGAGCGCTTGTCCGGCTCGCAGGCGCCGGCGCTGTATGCGCTGTCGCTG CTGGTGGTGTTCCTCTGCCTGGCGGCCCTGTACGAAAGCTGGTCGATTCCGTTCTCGGTG ATGCTGGTGGTGCCGTTGGGCGTGATCGGTGCGCTGCTGGCGACGTCCATGCGCGGCCTG TCCAACGACGTGTTCTTCCAGGTGGGCCTGTTGACGACCATCGGCCTGTCGGCGAAGAAC GCCATTCTCATCGTGGAGTTCGCCAAGGAGCTGCACGAGCAGGGCAAGGGCATCGTCGAG GCGGCCATCGAAGCCTGCCGCATGCGTCTGCGGCCGATCGTGATGACCTCCCTGGCGTTC ATCCTCGGCGTGGTCCCGCTGGCGATCTCCACCGGCGCCGGCTCGGGCAGCCAGCATGCG ATCGGTACCGGCGTGATCGGCGGCATGGTCACTGCGACCGTCCTGGCGATCTTCTGGGTA CCGCTGTTCTACGTGGCGGTCAGCACGCTGTTCAAGGACGAGGCGTCCAAGCAGCAGGCG TCCGTCGAAAAGGGGCAATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P52002 UniProtKB Entry Name MEXB_PSEAE - General References
- Poole K, Heinrichs DE, Neshat S: Cloning and sequence analysis of an EnvCD homologue in Pseudomonas aeruginosa: regulation by iron and possible involvement in the secretion of the siderophore pyoverdine. Mol Microbiol. 1993 Nov;10(3):529-44. [Article]
- Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. [Article]
- Mahajan-Miklos S, Tan MW, Rahme LG, Ausubel FM: Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model. Cell. 1999 Jan 8;96(1):47-56. [Article]
- Blonder J, Goshe MB, Xiao W, Camp DG 2nd, Wingerd M, Davis RW, Smith RD: Global analysis of the membrane subproteome of Pseudomonas aeruginosa using liquid chromatography-tandem mass spectrometry. J Proteome Res. 2004 May-Jun;3(3):434-44. [Article]
- Poole K, Krebes K, McNally C, Neshat S: Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon. J Bacteriol. 1993 Nov;175(22):7363-72. [Article]
- Li XZ, Nikaido H, Poole K: Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1995 Sep;39(9):1948-53. [Article]
- Li XZ, Zhang L, Poole K: Role of the multidrug efflux systems of Pseudomonas aeruginosa in organic solvent tolerance. J Bacteriol. 1998 Jun;180(11):2987-91. [Article]
- Guan L, Ehrmann M, Yoneyama H, Nakae T: Membrane topology of the xenobiotic-exporting subunit, MexB, of the MexA,B-OprM extrusion pump in Pseudomonas aeruginosa. J Biol Chem. 1999 Apr 9;274(15):10517-22. doi: 10.1074/jbc.274.15.10517. [Article]