Beta-lactamase

Details

Name
Beta-lactamase
Synonyms
  • 3.5.2.6
  • Cefuroximase
  • cumA
Gene Name
blaB
Organism
Proteus vulgaris
Amino acid sequence
>lcl|BSEQ0012223|Beta-lactamase
MTMFKTTFRQTATIAVSLISLLVSPMLWANTNNTIEEQLSTLEKYSQGRLGVALINTEDN
SQITYRGEERFAMASTSKVMAVAAVLKESEKQAGLLDKNITIKKSDLVAYSPITEKHLVT
GMSLAQLSAATLQYSDNTAMNKILDYLGGPAKVTQFARSINDVTYRLDRKEPELNTAIHG
DPRDTTSPIAMAKSLQALTLGDALGQSQRQQLVTWLKGNTTGDHSIKAGLPKHWIVGDKT
GSGDYGTTNDIAVIWPKNHAPLILVVYFTQQEQDAKYRKDIIVKATEIVTKEISNSPQTK
Number of residues
300
Molecular Weight
32991.385
Theoretical pI
9.35
GO Classification
Functions
beta-lactamase activity
Processes
beta-lactam antibiotic catabolic process / response to antibiotic
General Function
Beta-lactamase activity
Specific Function
Hydrolyzes broad-spectrum beta-lactam antibiotics. Active against cephalosporins such as cefuroxime and cefotaxime.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0006221|903 bp
ATGACTATGTTTAAAACAACATTTCGCCAAACAGCGACGATTGCAGTTTCATTAATATCT
CTATTGGTATCTCCAATGCTATGGGCTAACACCAATAATACGATTGAAGAGCAATTAAGT
ACGCTTGAAAAATATAGCCAAGGTCGTTTAGGTGTTGCTTTAATCAACACGGAAGATAAT
TCACAAATAACATATCGTGGTGAAGAACGTTTTGCGATGGCAAGTACAAGTAAGGTTATG
GCTGTTGCGGCAGTTTTAAAAGAGAGTGAAAAACAAGCGGGATTATTAGATAAGAATATT
ACAATTAAAAAATCCGACTTAGTTGCTTACAGCCCTATTACAGAAAAACATTTAGTAACA
GGAATGTCTTTAGCTCAATTAAGTGCTGCTACGTTGCAATATAGCGATAATACAGCAATG
AATAAAATCTTAGATTATTTAGGTGGTCCAGCCAAAGTCACTCAATTTGCACGTTCAATT
AATGATGTAACTTATCGCCTAGATCGTAAAGAGCCTGAATTAAATACAGCAATTCATGGT
GATCCTCGTGATACGACTTCTCCAATTGCTATGGCTAAAAGCCTTCAAGCATTGACATTA
GGTGACGCATTAGGTCAATCTCAACGTCAACAGCTTGTTACTTGGTTAAAAGGCAATACA
ACAGGTGATCACAGTATTAAAGCGGGTTTACCAAAACACTGGATTGTTGGGGATAAAACT
GGCAGTGGTGATTATGGTACGACTAATGATATCGCCGTTATTTGGCCTAAAAACCATGCA
CCATTAATTTTAGTGGTCTATTTCACACAACAAGAACAAGATGCAAAATACCGTAAAGAT
ATTATTGTGAAAGCCACAGAGATTGTAACAAAAGAAATATCTAATTCACCTCAAACAAAA
TAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP52664
UniProtKB Entry NameBLAB_PROVU
GenBank Gene IDX80128
General References
  1. Datz M, Joris B, Azab EA, Galleni M, Van Beeumen J, Frere JM, Martin HH: A common system controls the induction of very different genes. The class-A beta-lactamase of Proteus vulgaris and the enterobacterial class-C beta-lactamase. Eur J Biochem. 1994 Nov 15;226(1):149-57. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB038142-(N-morpholino)ethanesulfonic acidexperimentalunknownDetails
DB01598ImipenemapprovedunknownactivatorDetails