Biotin biosynthesis cytochrome P450

Details

Name
Biotin biosynthesis cytochrome P450
Synonyms
  • 1.14.15.12
  • CYP107H
Gene Name
bioI
Organism
Bacillus subtilis (strain 168)
Amino acid sequence
>lcl|BSEQ0017336|Biotin biosynthesis cytochrome P450
MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTGYEETAAILKDARFKVR
TPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTPRTTESYQPYIIETVHHLL
DQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKEWAASLIQTIDFTRSRKALTE
GNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKDKLTEEEAASTCILLAIAGHETT
VNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECLRYESPTQMTARVASEDIDICGVTI
RQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNPHLSFGHGHHVCLGSSLARLEAQIAIN
TLLQRMPSLNLADFEWRYRPLFGFRALEELPVTFE
Number of residues
395
Molecular Weight
44864.93
Theoretical pI
6.65
GO Classification
Functions
heme binding / iron ion binding / monooxygenase activity / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Processes
biotin biosynthetic process
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Specific Function
Catalyzes the C-C bond cleavage of fatty acid linked to acyl carrier protein (ACP) to generate pimelic acid for biotin biosynthesis. It has high affinity for long-chain fatty acids with the greatest affinity for myristic acid.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0017337|Biotin biosynthesis cytochrome P450 (bioI)
GTGACAATTGCATCGTCAACTGCATCTTCTGAGTTTTTGAAAAACCCATATTCTTTTTAC
GACACATTGCGAGCTGTTCATCCTATCTATAAAGGGAGTTTCTTAAAATACCCGGGCTGG
TATGTCACAGGATATGAAGAAACGGCTGCTATTTTGAAAGATGCGAGATTCAAAGTCCGC
ACCCCGCTGCCTGAGAGCTCAACCAAATATCAGGACCTTTCACATGTGCAAAATCAAATG
ATGCTGTTTCAGAACCAGCCTGATCATAGACGATTGCGGACGCTTGCCAGCGGAGCGTTT
ACGCCGAGAACGACAGAGAGTTATCAGCCGTATATCATTGAAACTGTCCATCATTTGCTT
GATCAAGTGCAAGGTAAAAAAAAGATGGAGGTCATTTCGGACTTTGCTTTTCCTTTAGCA
AGTTTTGTCATAGCTAACATTATAGGTGTACCGGAGGAAGATAGGGAGCAATTAAAGGAG
TGGGCTGCGAGTCTCATTCAAACGATTGATTTTACCCGCTCAAGAAAGGCATTAACAGAG
GGCAATATTATGGCTGTGCAGGCTATGGCATATTTCAAAGAGCTGATTCAAAAGAGAAAA
CGCCACCCTCAACAGGATATGATCAGCATGCTCTTGAAGGGGAGAGAAAAGGATAAGCTG
ACGGAAGAGGAGGCGGCATCTACGTGCATATTGCTGGCGATCGCCGGACATGAGACAACG
GTCAATCTCATCAGCAATTCAGTCCTTTGTCTGCTGCAGCATCCAGAACAGCTTTTGAAA
CTGAGAGAAAATCCAGATCTTATTGGTACCGCAGTCGAGGAATGTTTACGCTATGAAAGC
CCCACGCAAATGACAGCCAGAGTTGCGTCAGAGGATATTGACATCTGCGGGGTGACGATC
CGTCAAGGAGAACAAGTCTATCTTTTGTTAGGAGCGGCTAATCGAGACCCTAGCATATTC
ACGAACCCCGATGTCTTCGATATTACGAGAAGTCCTAATCCGCATCTTTCATTCGGGCAT
GGCCATCATGTTTGCTTAGGGTCCTCGCTGGCACGATTAGAAGCGCAAATTGCGATTAAC
ACTCTTCTGCAGCGAATGCCCAGCCTTAATCTTGCGGATTTTGAATGGCGGTATCGGCCG
CTTTTTGGATTTCGGGCGCTTGAGGAGCTGCCGGTGACTTTTGAATAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP53554
UniProtKB Entry NameBIOI_BACSU
GenBank Protein ID1277025
GenBank Gene IDU51868
General References
  1. Bower S, Perkins JB, Yocum RR, Howitt CL, Rahaim P, Pero J: Cloning, sequencing, and characterization of the Bacillus subtilis biotin biosynthetic operon. J Bacteriol. 1996 Jul;178(14):4122-30. [Article]
  2. Lapidus A, Galleron N, Sorokin A, Ehrlich SD: Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region. Microbiology. 1997 Nov;143 ( Pt 11):3431-41. [Article]
  3. Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
  4. Stok JE, De Voss J: Expression, purification, and characterization of BioI: a carbon-carbon bond cleaving cytochrome P450 involved in biotin biosynthesis in Bacillus subtilis. Arch Biochem Biophys. 2000 Dec 15;384(2):351-60. [Article]
  5. Green AJ, Rivers SL, Cheeseman M, Reid GA, Quaroni LG, Macdonald ID, Chapman SK, Munro AW: Expression, purification and characterization of cytochrome P450 Biol: a novel P450 involved in biotin synthesis in Bacillus subtilis. J Biol Inorg Chem. 2001 Jun;6(5-6):523-33. [Article]
  6. Lawson RJ, Leys D, Sutcliffe MJ, Kemp CA, Cheesman MR, Smith SJ, Clarkson J, Smith WE, Haq I, Perkins JB, Munro AW: Thermodynamic and biophysical characterization of cytochrome P450 BioI from Bacillus subtilis. Biochemistry. 2004 Oct 5;43(39):12410-26. [Article]
  7. Cryle MJ, De Voss JJ: Carbon-carbon bond cleavage by cytochrome p450(BioI)(CYP107H1). Chem Commun (Camb). 2004 Jan 7;(1):86-7. Epub 2003 Nov 17. [Article]
  8. Cryle MJ, Schlichting I: Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15696-701. doi: 10.1073/pnas.0805983105. Epub 2008 Oct 6. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04450Heptyl 1-ThiohexopyranosideexperimentalunknownDetails