Chromaffin granule amine transporter
Details
- Name
- Chromaffin granule amine transporter
- Synonyms
- Solute carrier family 18 member 1
- VAT1
- Vesicular amine transporter 1
- VMAT1
- Gene Name
- SLC18A1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009591|Chromaffin granule amine transporter MLRTILDAPQRLLKEGRASRQLVLVVVFVALLLDNMLFTVVVPIVPTFLYDMEFKEVNSS LHLGHAGSSPHALASPAFSTIFSFFNNNTVAVEESVPSGIAWMNDTASTIPPPATEAISA HKNNCLQGTGFLEEEITRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLS TVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASVYTDDHERGRAMGTALGGLALGL LVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQPSKVSPESAKGTPLFMLLKDP YILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLA NKMGRWLCSLIGMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDL RHTSVYGSVYAIADVAFCMGFAIGPSTGGAIVKAIGFPWLMVITGVINIVYAPLCYYLRS PPAKEEKLAILSQDCPMETRMYATQKPTKEFPLGEDSDEEPDHEE
- Number of residues
- 525
- Molecular Weight
- 56256.71
- Theoretical pI
- Not Available
- GO Classification
- Functionsdrug transmembrane transporter activity / monoamine transmembrane transporter activity / serotonin transmembrane transporter activityProcessescellular response to lithium ion / monoamine transport / negative regulation of serotonin uptake / positive regulation of dopamine secretion / serotonin uptake / transmembrane transportComponentsclathrin-sculpted monoamine transport vesicle membrane / endoplasmic reticulum membrane / integral component of membrane
- General Function
- Serotonin transmembrane transporter activity
- Specific Function
- Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells.
- Pfam Domain Function
- MFS_1 (PF07690)
- Transmembrane Regions
- 22-42 139-158 168-188 198-218 228-250 257-279 300-319 336-360 366-386 398-418 423-443 449-470
- Cellular Location
- Cytoplasmic vesicle membrane
- Gene sequence
>lcl|BSEQ0021405|Chromaffin granule amine transporter (SLC18A1) ATGCTCCGGACCATTCTGGATGCTCCCCAGCGGTTGCTGAAGGAGGGGAGAGCGTCCCGG CAGCTGGTGCTGGTGGTGGTATTCGTCGCTTTGCTCCTGGACAACATGCTGTTTACTGTG GTGGTGCCAATTGTGCCCACCTTCCTATATGACATGGAGTTCAAAGAAGTCAACTCTTCT CTGCACCTCGGCCATGCCGGAAGTTCCCCACATGCCCTCGCCTCTCCTGCCTTTTCCACC ATCTTCTCCTTCTTCAACAACAACACCGTGGCTGTTGAAGAAAGCGTACCTAGTGGAATA GCATGGATGAATGACACTGCCAGCACCATCCCACCTCCAGCCACTGAAGCCATCTCAGCT CATAAAAACAACTGCTTGCAAGGCACAGGTTTCTTGGAGGAAGAGATTACCCGGGTCGGG GTTCTGTTTGCTTCAAAGGCTGTGATGCAACTTCTGGTCAACCCATTCGTGGGCCCTCTC ACCAACAGGATTGGATATCATATCCCCATGTTTGCTGGCTTTGTTATCATGTTTCTCTCC ACAGTTATGTTTGCTTTTTCTGGGACCTATACTCTACTCTTTGTGGCCCGAACCCTTCAA GGCATTGGATCTTCATTTTCATCTGTTGCAGGTCTTGGAATGCTGGCCAGTGTCTACACT GATGACCATGAGAGAGGACGAGCCATGGGAACTGCTCTGGGGGGCCTGGCCTTGGGGTTG CTGGTGGGAGCTCCCTTTGGAAGTGTAATGTACGAGTTTGTTGGGAAGTCTGCACCCTTC CTCATCCTGGCCTTCCTGGCACTACTGGATGGAGCACTCCAGCTTTGCATCCTACAGCCT TCCAAAGTCTCTCCTGAGAGTGCCAAGGGGACTCCCCTCTTTATGCTTCTCAAAGACCCT TACATCCTGGTGGCTGCAGGGTCCATCTGCTTTGCCAACATGGGGGTGGCCATCCTGGAG CCCACACTGCCCATCTGGATGATGCAGACCATGTGCTCCCCCAAGTGGCAGCTGGGTCTA GCTTTCTTGCCTGCCAGTGTGTCCTACCTCATTGGCACCAACCTCTTTGGTGTGTTGGCC AACAAGATGGGTCGGTGGCTGTGTTCCCTAATCGGGATGCTGGTAGTAGGTACCAGCTTG CTCTGTGTTCCTCTGGCTCACAATATTTTTGGTCTCATTGGCCCCAATGCAGGGCTTGGC CTTGCCATAGGCATGGTGGATTCTTCTATGATGCCCATCATGGGGCACCTGGTGGATCTA CGCCACACCTCGGTGTATGGGAGTGTCTACGCCATCGCTGATGTGGCTTTTTGCATGGGC TTTGCTATAGGTCCATCCACCGGTGGTGCCATTGTAAAGGCCATCGGTTTTCCCTGGCTC ATGGTCATCACTGGGGTCATCAACATCGTCTATGCTCCACTCTGCTACTACCTGCGGAGC CCCCCGGCAAAGGAAGAGAAGCTTGCTATTCTGAGTCAGGACTGCCCCATGGAGACCCGG ATGTATGCAACCCAGAAGCCCACGAAGGAATTTCCTCTGGGGGAGGACAGTGATGAGGAG CCTGACCATGAGGAGTAG
- Chromosome Location
- 8
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P54219 UniProtKB Entry Name VMAT1_HUMAN HGNC ID HGNC:10934 - General References
- Erickson JD, Schafer MK, Bonner TI, Eiden LE, Weihe E: Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter. Proc Natl Acad Sci U S A. 1996 May 14;93(10):5166-71. [Article]
- Nusbaum C, Mikkelsen TS, Zody MC, Asakawa S, Taudien S, Garber M, Kodira CD, Schueler MG, Shimizu A, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Allen NR, Anderson S, Asakawa T, Blechschmidt K, Bloom T, Borowsky ML, Butler J, Cook A, Corum B, DeArellano K, DeCaprio D, Dooley KT, Dorris L 3rd, Engels R, Glockner G, Hafez N, Hagopian DS, Hall JL, Ishikawa SK, Jaffe DB, Kamat A, Kudoh J, Lehmann R, Lokitsang T, Macdonald P, Major JE, Matthews CD, Mauceli E, Menzel U, Mihalev AH, Minoshima S, Murayama Y, Naylor JW, Nicol R, Nguyen C, O'Leary SB, O'Neill K, Parker SC, Polley A, Raymond CK, Reichwald K, Rodriguez J, Sasaki T, Schilhabel M, Siddiqui R, Smith CL, Sneddon TP, Talamas JA, Tenzin P, Topham K, Venkataraman V, Wen G, Yamazaki S, Young SK, Zeng Q, Zimmer AR, Rosenthal A, Birren BW, Platzer M, Shimizu N, Lander ES: DNA sequence and analysis of human chromosome 8. Nature. 2006 Jan 19;439(7074):331-5. [Article]
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- Essand M, Vikman S, Grawe J, Gedda L, Hellberg C, Oberg K, Totterman TH, Giandomenico V: Identification and characterization of a novel splicing variant of vesicular monoamine transporter 1. J Mol Endocrinol. 2005 Dec;35(3):489-501. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01363 Ephedra sinica root nutraceutical yes inhibitor Details DB01442 MMDA experimental, illicit yes inhibitor Details DB01577 Metamfetamine approved, illicit, withdrawn yes inhibitor Details DB00206 Reserpine approved, investigational, withdrawn unknown inhibitor Details DB00368 Norepinephrine approved unknown binder Details