Ribonuclease Z
Details
- Name
- Ribonuclease Z
- Synonyms
- 3.1.26.11
- RNase Z
- tRNA 3 endonuclease
- tRNase Z
- yqjK
- Gene Name
- rnz
- Organism
- Bacillus subtilis (strain 168)
- Amino acid sequence
>lcl|BSEQ0012224|Ribonuclease Z MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQHQILHTTIKPRKIEKIF ITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFIETSLAVTKTHLTYPLAIQEI EEGIVFEDDQFIVTAVSVIHGVEAFGYRVQEKDVPGSLKADVLKEMNIPPGPVYQKIKKG ETVTLEDGRIINGNDFLEPPKKGRSVVFSGDTRVSDKLKELARDCDVLVHEATFAKEDRK LAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQGDASLELQKEAVDVFPNSVAAYDFL EVNVPRG
- Number of residues
- 307
- Molecular Weight
- 34022.58
- Theoretical pI
- 6.19
- GO Classification
- Functions3'-tRNA processing endoribonuclease activity / zinc ion binding
- General Function
- Zinc ion binding
- Specific Function
- Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
- Pfam Domain Function
- Lactamase_B_2 (PF12706)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0012225|Ribonuclease Z (rnz) GTGGAATTACTTTTTTTAGGGACGGGAGCCGGCATCCCCGCCAAGGCGAGAAATGTAACG TCGGTGGCATTAAAATTGCTTGAAGAAAGGCGTTCGGTATGGCTTTTTGACTGCGGGGAA GCCACACAGCATCAAATTTTACATACAACGATTAAACCTCGTAAAATAGAGAAAATCTTT ATTACACACATGCACGGCGATCATGTATACGGACTTCCGGGGCTTCTGGGGAGCCGTTCC TTTCAAGGCGGAGAGGACGAGCTGACAGTGTACGGACCTAAAGGGATCAAGGCGTTTATT GAAACAAGCCTTGCCGTCACGAAAACCCATTTGACATATCCGCTTGCGATCCAGGAAATT GAAGAAGGAATCGTGTTTGAGGACGATCAGTTTATTGTCACAGCGGTATCTGTTATTCAT GGAGTGGAAGCCTTCGGGTACCGTGTGCAGGAAAAAGACGTACCGGGTTCCTTGAAGGCT GACGTATTAAAAGAAATGAACATCCCGCCCGGACCTGTATATCAGAAAATCAAAAAAGGC GAAACGGTAACGCTTGAAGACGGACGAATCATCAATGGGAATGATTTTCTGGAGCCTCCT AAAAAGGGAAGATCTGTTGTGTTCTCCGGTGATACGAGAGTAAGTGACAAACTAAAAGAG CTTGCGAGGGATTGTGATGTGCTTGTTCATGAAGCAACCTTTGCTAAGGAAGACCGTAAA CTTGCTTATGATTATTATCACAGTACAACGGAACAAGCGGCTGTAACAGCGAAAGAAGCA AGAGCGAAGCAGCTCATTTTAACCCATATCAGCGCAAGATATCAGGGAGATGCTTCTTTG GAGCTTCAAAAAGAAGCGGTTGACGTTTTCCCCAATAGCGTGGCGGCATATGATTTCTTA GAGGTAAACGTCCCGCGAGGCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P54548 UniProtKB Entry Name RNZ_BACSU GenBank Gene ID D84432 - General References
- Mizuno M, Masuda S, Takemaru K, Hosono S, Sato T, Takeuchi M, Kobayashi Y: Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the Bacillus subtilis genome containing the skin element and many sporulation genes. Microbiology. 1996 Nov;142 ( Pt 11):3103-11. [Article]
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- Pellegrini O, Nezzar J, Marchfelder A, Putzer H, Condon C: Endonucleolytic processing of CCA-less tRNA precursors by RNase Z in Bacillus subtilis. EMBO J. 2003 Sep 1;22(17):4534-43. [Article]
- Li de la Sierra-Gallay I, Pellegrini O, Condon C: Structural basis for substrate binding, cleavage and allostery in the tRNA maturase RNase Z. Nature. 2005 Feb 10;433(7026):657-61. Epub 2005 Jan 16. [Article]
- Li de la Sierra-Gallay I, Mathy N, Pellegrini O, Condon C: Structure of the ubiquitous 3' processing enzyme RNase Z bound to transfer RNA. Nat Struct Mol Biol. 2006 Apr;13(4):376-7. Epub 2006 Mar 5. [Article]