Chorismate synthase
Details
- Name
- Chorismate synthase
- Synonyms
- 4.2.3.5
- 5-enolpyruvylshikimate-3-phosphate phospholyase
- CS
- Gene Name
- aroC
- Organism
- Helicobacter pylori (strain ATCC 700392 / 26695)
- Amino acid sequence
>lcl|BSEQ0012113|Chorismate synthase MNTLGRFLRLTTFGESHGDVIGGVLDGMPSGIKIDYALLENEMKRRQGGRNVFITPRKED DKVEITSGVFEDFSTGTPIGFLIHNQRARSKDYDNIKNLFRPSHADFTYFHKYGIRDFRG GGRSSARESAIRVAAGAFAKMLLREIGIVCESGIIEIGGIKAKNYDFNHALKSEIFALDE EQEEAQKTAIQNAIKNHDSIGGVALIRARSIKTNQKLPIGLGQGLYAKLDAKIAEAMMGL NGVKAVEIGKGVESSLLKGSEYNDLMDQKGFLSNRSGGVLGGMSNGEEIIVRVHFKPTPS IFQPQRTIDINGNECECLLKGRHDPCIAIRGSVVCESLLALVLADMVLLNLTSKIEYLKT IYNEN
- Number of residues
- 365
- Molecular Weight
- 40099.6
- Theoretical pI
- 8.21
- GO Classification
- Functionschorismate synthase activity / FMN bindingProcessesaromatic amino acid family biosynthetic process / chorismate biosynthetic process
- General Function
- Fmn binding
- Specific Function
- Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
- Pfam Domain Function
- Chorismate_synt (PF01264)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0012114|Chorismate synthase (aroC) ATGAACACTTTGGGGCGTTTTTTAAGGCTCACGACTTTTGGGGAATCGCATGGGGATGTG ATAGGGGGGGTATTAGACGGCATGCCTAGCGGGATTAAAATAGACTATGCGCTATTAGAA AATGAAATGAAGCGCCGCCAAGGGGGGAGGAACGTTTTCATTACGCCACGAAAAGAAGAC GATAAAGTGGAAATAACAAGCGGGGTTTTTGAAGATTTTAGCACAGGGACTCCTATAGGG TTTTTAATCCACAACCAAAGGGCTAGGAGCAAGGATTACGATAACATTAAAAACCTTTTT AGGCCTAGCCATGCGGATTTCACTTATTTTCATAAATACGGCATTAGGGATTTTAGGGGT GGGGGGAGGAGTTCGGCCAGAGAGAGTGCTATAAGAGTGGCTGCTGGGGCGTTTGCTAAA ATGCTTTTAAGAGAAATCGGTATTGTTTGTGAAAGCGGGATTATAGAAATTGGGGGTATT AAAGCCAAAAATTATGATTTTAATCACGCCTTAAAAAGCGAGATTTTTGCCCTAGATGAA GAACAAGAAGAAGCGCAAAAAACAGCCATTCAAAACGCTATCAAAAACCACGATAGCATA GGGGGTGTGGCTTTGATTAGAGCGAGGAGCATAAAAACCAATCAAAAGCTCCCCATTGGC TTAGGTCAAGGGCTATACGCTAAATTAGACGCTAAAATCGCTGAAGCGATGATGGGGCTT AATGGGGTGAAAGCGGTTGAAATAGGCAAGGGGGTAGAAAGCTCTTTATTAAAAGGCTCA GAGTATAATGATTTAATGGATCAAAAGGGGTTTTTGAGCAATCGTAGCGGAGGGGTTTTA GGGGGCATGAGCAATGGGGAAGAAATCATTGTTAGAGTGCATTTCAAACCCACGCCAAGC ATTTTCCAACCTCAACGAACCATAGACATTAATGGCAATGAGTGCGAATGCTTGTTAAAG GGCAGGCATGATCCTTGCATTGCGATTAGAGGGAGCGTGGTGTGCGAGAGTTTGTTAGCG TTGGTGTTGGCTGATATGGTATTACTCAATTTGACTTCAAAAATAGAGTATTTAAAAACG ATTTATAATGAGAATTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P56122 UniProtKB Entry Name AROC_HELPY GenBank Gene ID AE000511 - General References
- Tomb JF, White O, Kerlavage AR, Clayton RA, Sutton GG, Fleischmann RD, Ketchum KA, Klenk HP, Gill S, Dougherty BA, Nelson K, Quackenbush J, Zhou L, Kirkness EF, Peterson S, Loftus B, Richardson D, Dodson R, Khalak HG, Glodek A, McKenney K, Fitzegerald LM, Lee N, Adams MD, Hickey EK, Berg DE, Gocayne JD, Utterback TR, Peterson JD, Kelley JM, Cotton MD, Weidman JM, Fujii C, Bowman C, Watthey L, Wallin E, Hayes WS, Borodovsky M, Karp PD, Smith HO, Fraser CM, Venter JC: The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature. 1997 Aug 7;388(6642):539-47. [Article]
- Ahn HJ, Yoon HJ, Lee B 2nd, Suh SW: Crystal structure of chorismate synthase: a novel FMN-binding protein fold and functional insights. J Mol Biol. 2004 Feb 27;336(4):903-15. [Article]