Dihydroneopterin aldolase

Details

Name
Dihydroneopterin aldolase
Synonyms
  • 4.1.2.25
  • 7,8-dihydroneopterin 2'-epimerase
  • 7,8-dihydroneopterin aldolase
  • 7,8-dihydroneopterin epimerase
  • DHNA
  • Dihydroneopterin epimerase
Gene Name
folB
Organism
Staphylococcus aureus
Amino acid sequence
>lcl|BSEQ0010898|Dihydroneopterin aldolase
MQDTIFLKGMRFYGYHGALSAENEIGQIFKVDVTLKVDLSEAGRTDNVIDTVHYGEVFEE
VKSIMEGKAVNLLEHLAERIANRINSQYNRVMETKVRITKENPPIPGHYDGVGIEIVREN
K
Number of residues
121
Molecular Weight
13750.58
Theoretical pI
5.64
GO Classification
Functions
dihydroneopterin aldolase activity / isomerase activity
Processes
folic acid biosynthetic process / tetrahydrofolate biosynthetic process
General Function
Isomerase activity
Specific Function
Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. Can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP56740
UniProtKB Entry NameFOLB_STAAU
General References
  1. Hennig M, D'Arcy A, Hampele IC, Page MG, Oefner C, Dale GE: Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from Staphylococcus aureus. Nat Struct Biol. 1998 May;5(5):357-62. [Article]
  2. Sanders WJ, Nienaber VL, Lerner CG, McCall JO, Merrick SM, Swanson SJ, Harlan JE, Stoll VS, Stamper GF, Betz SF, Condroski KR, Meadows RP, Severin JM, Walter KA, Magdalinos P, Jakob CG, Wagner R, Beutel BA: Discovery of potent inhibitors of dihydroneopterin aldolase using CrystaLEAD high-throughput X-ray crystallographic screening and structure-directed lead optimization. J Med Chem. 2004 Mar 25;47(7):1709-18. [Article]
  3. Blaszczyk J, Li Y, Gan J, Yan H, Ji X: Structural basis for the aldolase and epimerase activities of Staphylococcus aureus dihydroneopterin aldolase. J Mol Biol. 2007 Apr 20;368(1):161-9. Epub 2007 Feb 9. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB017788-AminotheophyllineexperimentalunknownDetails
DB019063-(5-amino-7-hydroxy-(1,2,3)triazolo(4,5-d)pyrimidin-2-yl)benzoic acidexperimentalunknownDetails
DB021196-Hydroxymethyl-7,8-DihydropterinexperimentalunknownDetails
DB024899-MethylguanineexperimentalunknownDetails
DB032313-(5-Amino-7-oxo-3,7-dihydro-2H-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-(2-{[2-(hydroxymethyl)phenyl]sulfanyl}benzyl)benzamideexperimentalunknownDetails
DB035713-(5-amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-(3,5-dichlorobenzyl)-benzamideexperimentalunknownDetails
DB04168BropirimineexperimentalunknownDetails
DB044257,8-DihydroneopterinexperimentalunknownDetails
DB04400L-erythro-7,8-dihydrobiopterinexperimentalunknownDetails
DB06906ethyl 2-amino-4-hydroxypyrimidine-5-carboxylateexperimentalunknownDetails