Argininosuccinate synthase
Details
- Name
- Argininosuccinate synthase
- Synonyms
- 6.3.4.5
- Citrulline--aspartate ligase
- Gene Name
- argG
- Organism
- Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
- Amino acid sequence
>lcl|BSEQ0011036|Argininosuccinate synthase MKIVLAYSGGLDTSIILKWLKETYRAEVIAFTADIGQGEEVEEAREKALRTGASKAIALD LKEEFVRDFVFPMMRAGAVYEGYYLLGTSIARPLIAKHLVRIAEEEGAEAIAHGATGKGN DQVRFELTAYALKPDIKVIAPWREWSFQGRKEMIAYAEAHGIPVPVTQEKPYSMDANLLH ISYEGGVLEDPWAEPPKGMFRMTQDPEEAPDAPEYVEVEFFEGDPVAVNGERLSPAALLQ RLNEIGGRHGVGRVDIVENRFVGMKSRGVYETPGGTILYHARRAVESLTLDREVLHQRDM LSPKYAELVYYGFWYAPEREALQAYFDHVARSVTGVARLKLYKGNVYVVGRKAPKSLYRQ DLVSFDEAGGYDQKDAEGFIKIQALRLRVRALVEREGHGA
- Number of residues
- 400
- Molecular Weight
- 44815.725
- Theoretical pI
- 5.71
- GO Classification
- Functionsargininosuccinate synthase activity / ATP bindingProcessesarginine biosynthetic processComponentscytoplasm
- General Function
- Atp binding
- Specific Function
- Not Available
- Pfam Domain Function
- Arginosuc_synth (PF00764)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0011037|Argininosuccinate synthase (argG) ATGAAGATCGTCTTGGCCTACTCCGGCGGACTGGACACCAGCATCATCCTCAAGTGGCTC AAGGAGACCTATCGGGCCGAGGTCATCGCCTTCACCGCGGACATCGGCCAGGGGGAGGAG GTGGAGGAGGCCCGGGAGAAGGCGCTGAGGACGGGCGCTTCCAAGGCCATCGCCCTGGAC CTCAAGGAGGAGTTCGTCCGCGACTTCGTCTTCCCCATGATGCGGGCTGGCGCGGTGTAC GAGGGCTACTACCTCCTCGGCACTTCCATCGCGAGGCCTTTGATCGCCAAGCACCTGGTG CGGATCGCCGAGGAGGAGGGGGCGGAGGCCATCGCCCACGGGGCCACGGGGAAGGGGAAC GACCAGGTGCGCTTTGAGCTCACCGCCTACGCCCTGAAGCCCGACATCAAGGTCATCGCC CCCTGGCGGGAGTGGAGCTTCCAGGGCCGCAAGGAGATGATCGCCTACGCCGAGGCCCAC GGCATTCCCGTCCCCGTGACCCAGGAGAAGCCTTACTCCATGGACGCCAACCTCTTGCAT ATTTCCTACGAGGGCGGGGTCCTCGAGGACCCCTGGGCCGAGCCCCCCAAGGGGATGTTC CGCATGACCCAAGACCCCGAGGAGGCTCCCGACGCCCCGGAGTACGTGGAGGTGGAGTTT TTTGAGGGCGATCCCGTGGCGGTGAACGGGGAGAGGCTTTCCCCGGCGGCCCTTCTGCAG AGGCTCAACGAGATCGGGGGGCGTCACGGGGTGGGCCGGGTGGACATCGTGGAGAACCGC TTTGTGGGCATGAAGTCCCGGGGGGTCTACGAGACCCCGGGGGGGACGATCCTCTACCAC GCCAGGCGGGCGGTGGAAAGCCTCACCCTGGACCGGGAGGTCCTCCACCAAAGGGACATG CTCTCCCCCAAGTACGCCGAGCTCGTCTACTACGGCTTCTGGTACGCCCCGGAGCGGGAG GCCCTTCAGGCCTACTTTGACCACGTGGCGAGAAGCGTCACCGGCGTGGCCCGGCTCAAG CTCTACAAGGGGAACGTCTACGTGGTGGGAAGGAAGGCCCCGAAGAGCCTCTACCGCCAG GACCTGGTCTCCTTTGACGAGGCAGGGGGCTACGACCAGAAGGACGCCGAGGGCTTCATC AAGATCCAGGCCCTGCGCCTCCGGGTGCGGGCCCTTGTGGAGAGGGAGGGCCATGGCGCA TAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P59846 UniProtKB Entry Name ASSY_THET8 GenBank Protein ID 55771665 GenBank Gene ID AP008226 - General References
- Goto M, Nakajima Y, Hirotsu K: Crystal structure of argininosuccinate synthetase from Thermus thermophilus HB8. Structural basis for the catalytic action. J Biol Chem. 2002 May 3;277(18):15890-6. Epub 2002 Feb 13. [Article]
- Goto M, Omi R, Miyahara I, Sugahara M, Hirotsu K: Structures of argininosuccinate synthetase in enzyme-ATP substrates and enzyme-AMP product forms: stereochemistry of the catalytic reaction. J Biol Chem. 2003 Jun 20;278(25):22964-71. Epub 2003 Apr 8. [Article]