Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Details

Name
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Synonyms
  • 3.1.3.16
  • MMAC1
  • Mutated in multiple advanced cancers 1
  • Phosphatase and tensin homolog
  • TEP1
Gene Name
PTEN
Organism
Humans
Amino acid sequence
>lcl|BSEQ0009278|Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSK
HKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVA
AIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSY
LLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMY
FEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEI
DSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEAS
SSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV
Number of residues
403
Molecular Weight
47165.92
Theoretical pI
Not Available
GO Classification
Functions
anaphase-promoting complex binding / enzyme binding / identical protein binding / inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity / lipid binding / magnesium ion binding / PDZ domain binding / phosphatidylinositol-3-phosphatase activity / phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity / phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity / phosphoprotein phosphatase activity / protein serine/threonine phosphatase activity / protein tyrosine phosphatase activity / protein tyrosine/serine/threonine phosphatase activity
Processes
activation of APC-Cdc20 complex activity / adult behavior / aging / angiogenesis / apoptotic process / brain morphogenesis / canonical Wnt signaling pathway / cardiac muscle tissue development / cell migration / cell proliferation / cellular response to hypoxia / central nervous system development / central nervous system myelin maintenance / central nervous system neuron axonogenesis / dendritic spine morphogenesis / dentate gyrus development / endothelial cell migration / epidermal growth factor receptor signaling pathway / Fc-epsilon receptor signaling pathway / fibroblast growth factor receptor signaling pathway / forebrain morphogenesis / gene expression / heart development / innate immune response / inositol phosphate dephosphorylation / inositol phosphate metabolic process / learning or memory / locomotor rhythm / locomotory behavior / long term synaptic depression / long-term synaptic potentiation / male mating behavior / maternal behavior / memory / multicellular organismal response to stress / negative regulation of apoptotic process / negative regulation of axonogenesis / negative regulation of cell aging / negative regulation of cell migration / negative regulation of cell proliferation / negative regulation of cell size / negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle / negative regulation of dendritic spine morphogenesis / negative regulation of epithelial cell proliferation / negative regulation of excitatory postsynaptic potential / negative regulation of focal adhesion assembly / negative regulation of G1/S transition of mitotic cell cycle / negative regulation of myelination / negative regulation of organ growth / negative regulation of phagocytosis / negative regulation of phosphatidylinositol 3-kinase signaling / negative regulation of protein kinase B signaling / negative regulation of protein phosphorylation / negative regulation of ribosome biogenesis / negative regulation of synaptic vesicle clustering / neuron-neuron synaptic transmission / neurotrophin TRK receptor signaling pathway / peptidyl-tyrosine dephosphorylation / phosphatidylinositol biosynthetic process / phosphatidylinositol dephosphorylation / phosphatidylinositol-mediated signaling / phospholipid metabolic process / platelet-derived growth factor receptor signaling pathway / positive regulation of apoptotic signaling pathway / positive regulation of cell proliferation / positive regulation of ERK1 and ERK2 cascade / positive regulation of excitatory postsynaptic potential / positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process / positive regulation of sequence-specific DNA binding transcription factor activity / postsynaptic density assembly / prepulse inhibition / presynaptic membrane assembly / prostate gland growth / protein dephosphorylation / protein kinase B signaling / protein stabilization / regulation of axon regeneration / regulation of B cell apoptotic process / regulation of cellular component size / regulation of cyclin-dependent protein serine/threonine kinase activity / regulation of myeloid cell apoptotic process / regulation of neuron projection development / regulation of protein stability / regulation of synaptic transmission, GABAergic / response to arsenic-containing substance / response to ATP / response to drug / response to estradiol / response to ethanol / response to glucose / response to nutrient / response to zinc ion / rhythmic synaptic transmission / small molecule metabolic process / social behavior / synapse assembly / synapse maturation / T cell receptor signaling pathway / transcription initiation from RNA polymerase II promoter
Components
apical plasma membrane / cell projection / cytoplasm / cytoplasmic side of plasma membrane / cytosol / dendritic spine / extracellular region / mitochondrion / myelin sheath adaxonal region / neuron projection / nucleoplasm / nucleus / plasma membrane / PML body / postsynaptic membrane / Schmidt-Lanterman incisure
General Function
Protein tyrosine/serine/threonine phosphatase activity
Specific Function
Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement.Isoform alpha: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0021732|Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)
ATGACAGCCATCATCAAAGAGATCGTTAGCAGAAACAAAAGGAGATATCAAGAGGATGGA
TTCGACTTAGACTTGACCTATATTTATCCAAACATTATTGCTATGGGATTTCCTGCAGAA
AGACTTGAAGGCGTATACAGGAACAATATTGATGATGTAGTAAGGTTTTTGGATTCAAAG
CATAAAAACCATTACAAGATATACAATCTTTGTGCTGAAAGACATTATGACACCGCCAAA
TTTAATTGCAGAGTTGCACAATATCCTTTTGAAGACCATAACCCACCACAGCTAGAACTT
ATCAAACCCTTTTGTGAAGATCTTGACCAATGGCTAAGTGAAGATGACAATCATGTTGCA
GCAATTCACTGTAAAGCTGGAAAGGGACGAACTGGTGTAATGATATGTGCATATTTATTA
CATCGGGGCAAATTTTTAAAGGCACAAGAGGCCCTAGATTTCTATGGGGAAGTAAGGACC
AGAGACAAAAAGGGAGTAACTATTCCCAGTCAGAGGCGCTATGTGTATTATTATAGCTAC
CTGTTAAAGAATCATCTGGATTATAGACCAGTGGCACTGTTGTTTCACAAGATGATGTTT
GAAACTATTCCAATGTTCAGTGGCGGAACTTGCAATCCTCAGTTTGTGGTCTGCCAGCTA
AAGGTGAAGATATATTCCTCCAATTCAGGACCCACACGACGGGAAGACAAGTTCATGTAC
TTTGAGTTCCCTCAGCCGTTACCTGTGTGTGGTGATATCAAAGTAGAGTTCTTCCACAAA
CAGAACAAGATGCTAAAAAAGGACAAAATGTTTCACTTTTGGGTAAATACATTCTTCATA
CCAGGACCAGAGGAAACCTCAGAAAAAGTAGAAAATGGAAGTCTATGTGATCAAGAAATC
GATAGCATTTGCAGTATAGAGCGTGCAGATAATGACAAGGAATATCTAGTACTTACTTTA
ACAAAAAATGATCTTGACAAAGCAAATAAAGACAAAGCCAACCGATACTTTTCTCCAAAT
TTTAAGGTGAAGCTGTACTTCACAAAAACAGTAGAGGAGCCGTCAAATCCAGAGGCTAGC
AGTTCAACTTCTGTAACACCAGATGTTAGTGACAATGAACCTGATCATTATAGATATTCT
GACACCACTGACTCTGATCCAGAGAATGAACCTTTTGATGAAGATCAGCATACACAAATT
ACAAAAGTCTGA
Chromosome Location
10
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP60484
UniProtKB Entry NamePTEN_HUMAN
HGNC IDHGNC:9588
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04327PhosphatidylethanolamineexperimentalunknownsubstrateDetails