Eukaryotic initiation factor 4A-I

Details

Name
Eukaryotic initiation factor 4A-I
Synonyms
  • 3.6.4.13
  • ATP-dependent RNA helicase eIF4A-1
  • DDX2A
  • eIF-4A-I
  • EIF4A
Gene Name
EIF4A1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049661|Eukaryotic initiation factor 4A-I
MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQ
RAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVV
MALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFV
LDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEE
LTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVS
AMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI
GRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI
Number of residues
406
Molecular Weight
46153.525
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / ATP-dependent RNA helicase activity / double-stranded RNA binding / helicase activity / mRNA binding / RNA binding / RNA cap binding / translation factor activity, RNA binding / translation initiation factor activity
Processes
nuclear-transcribed mRNA poly(A) tail shortening / regulation of gene expression / RNA secondary structure unwinding / translational initiation / viral process
Components
cytoplasm / cytosol / eukaryotic translation initiation factor 4F complex / extracellular exosome / extracellular matrix / membrane
General Function
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
Specific Function
Atp binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0049662|Eukaryotic initiation factor 4A-I (EIF4A1)
ATGTCTGCGAGCCAGGATTCCCGATCCAGAGACAATGGCCCCGATGGGATGGAGCCCGAA
GGCGTCATCGAGAGTAACTGGAATGAGATTGTTGACAGCTTTGATGACATGAACCTCTCG
GAGTCCCTTCTCCGTGGCATCTACGCGTATGGTTTTGAGAAGCCCTCTGCCATCCAGCAG
CGAGCCATTCTACCTTGTATCAAGGGTTATGATGTGATTGCTCAAGCCCAATCTGGGACT
GGGAAAACGGCCACATTTGCCATATCGATTCTGCAGCAGATTGAATTAGATCTAAAAGCC
ACCCAGGCCTTGGTCCTAGCACCCACTCGAGAATTGGCTCAGCAGATACAGAAGGTGGTC
ATGGCACTAGGAGACTACATGGGCGCCTCCTGTCACGCCTGTATCGGGGGCACCAACGTG
CGTGCTGAGGTGCAGAAACTGCAGATGGAAGCTCCCCACATCATCGTGGGTACCCCTGGC
CGTGTGTTTGATATGCTTAACCGGAGATACCTGTCCCCCAAATACATCAAGATGTTTGTA
CTGGATGAAGCTGACGAAATGTTAAGCCGTGGATTCAAGGACCAGATCTATGACATATTC
CAAAAGCTCAACAGCAACACCCAGGTAGTTTTGCTGTCAGCCACAATGCCTTCTGATGTG
CTTGAGGTGACCAAGAAGTTCATGAGGGACCCCATTCGGATTCTTGTCAAGAAGGAAGAG
TTGACCCTGGAGGGTATCCGCCAGTTCTACATCAACGTGGAACGAGAGGAGTGGAAGCTG
GACACACTATGTGACTTGTATGAAACCCTGACCATCACCCAGGCAGTCATCTTCATCAAC
ACCCGGAGGAAGGTGGACTGGCTCACCGAGAAGATGCATGCTCGAGATTTCACTGTATCC
GCCATGCATGGAGATATGGACCAAAAGGAACGAGACGTGATTATGAGGGAGTTTCGTTCT
GGCTCTAGCAGAGTTTTGATTACCACTGACCTGCTGGCCAGAGGCATTGATGTGCAGCAG
GTTTCTTTAGTCATCAACTATGACCTTCCCACCAACAGGGAAAACTATATCCACAGAATC
GGTCGAGGTGGACGGTTTGGCCGTAAAGGTGTGGCTATTAACATGGTGACAGAAGAAGAC
AAGAGGACTCTTCGAGACATTGAGACCTTCTACAACACCTCCATTGAGGAAATGCCCCTC
AATGTTGCTGACCTCATCTGA
Chromosome Location
17
Locus
17p13.1
External Identifiers
ResourceLink
UniProtKB IDP60842
UniProtKB Entry NameIF4A1_HUMAN
HGNC IDHGNC:3282
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB09130Copperapproved, investigationalunknownDetails