Protein S100-A10

Details

Name

Protein S100-A10

Synonyms

ANX2LG
CAL1L
Calpactin I light chain
Calpactin-1 light chain
Cellular ligand of annexin II
CLP11
p10 protein
p11
S100 calcium-binding protein A10

Gene Name

S100A10

Organism

Humans

Amino acid sequence

>lcl|BSEQ0049779|Protein S100-A10
MPSQMEHAMETMMFTFHKFAGDKGYLTKEDLRVLMEKEFPGFLENQKDPLAVDKIMKDLD
QCRDGKVGFQSFFSLIAGLTIACNDYFVVHMKQKGKK

Number of residues

Molecular Weight

11203.06

Theoretical pI

Not Available

GO Classification

Functions

calcium ion binding / ion channel binding / protein homodimerization activity

Processes

establishment of protein localization to plasma membrane / membrane budding / membrane raft assembly / positive regulation of binding / positive regulation of focal adhesion assembly / positive regulation of GTPase activity / positive regulation of stress fiber assembly / positive regulation of substrate adhesion-dependent cell spreading / protein heterotetramerization / response to drug

Components

endoplasmic reticulum / extracellular exosome / extrinsic component of plasma membrane

General Function

Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.

Specific Function

Calcium ion binding

Pfam Domain Function

S_100 (PF01023)

Transmembrane Regions

Not Available

Cellular Location

Not Available

Gene sequence

>lcl|BSEQ0049780|Protein S100-A10 (S100A10)
ATGCCATCTCAAATGGAACACGCCATGGAAACCATGATGTTTACATTTCACAAATTCGCT
GGGGATAAAGGCTACTTAACAAAGGAGGACCTGAGAGTACTCATGGAAAAGGAGTTCCCT
GGATTTTTGGAAAATCAAAAAGACCCTCTGGCTGTGGACAAAATAATGAAGGACCTGGAC
CAGTGTAGAGATGGCAAAGTGGGCTTCCAGAGCTTCTTTTCCCTAATTGCGGGCCTCACC
ATTGCATGCAATGACTATTTTGTAGTACACATGAAGCAGAAGGGAAAGAAGTAG

Chromosome Location

Locus

1q21.3

External Identifiers

Resource	Link
UniProtKB ID	P60903
UniProtKB Entry Name	S10AA_HUMAN
HGNC ID	HGNC:10487

General References

Kube E, Weber K, Gerke V: Primary structure of human, chicken, and Xenopus laevis p11, a cellular ligand of the Src-kinase substrate, annexin II. Gene. 1991 Jun 30;102(2):255-9. [Article]
Harder T, Kube E, Gerke V: Cloning and characterization of the human gene encoding p11: structural similarity to other members of the S-100 gene family. Gene. 1992 Apr 15;113(2):269-74. [Article]
Dooley TP, Weiland KL, Simon M: cDNA sequence of human p11 calpactin I light chain. Genomics. 1992 Jul;13(3):866-8. [Article]
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Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB12695	Phenethyl Isothiocyanate	investigational	unknown		Details