50S ribosomal protein L22

Details

Name
50S ribosomal protein L22
Synonyms
Not Available
Gene Name
rplV
Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Amino acid sequence
>lcl|BSEQ0052077|50S ribosomal protein L22
MAEITSAKAMARTVRVSPRKSRLVLDNIRGKSVADAIAILTFTPNKAAEIILKVLNSAVA
NAENNFGLDKANLVVSEAFANEGPTMKRFRPRAKGSASPINKRTAHITVAVAEK
Number of residues
114
Molecular Weight
12200.055
Theoretical pI
Not Available
GO Classification
Functions
rRNA binding / structural constituent of ribosome
Processes
response to antibiotic / translation
Components
large ribosomal subunit
General Function
This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).
Specific Function
Rrna binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0052078|50S ribosomal protein L22 (rplV)
ATGGCAGAAATTACTTCAGCTAAAGCAATGGCTCGTACAGTACGTGTTTCACCTCGTAAA
TCACGTCTTGTTCTTGATAACATCCGTGGTAAAAGCGTAGCCGATGCAATCGCAATCTTG
ACATTCACTCCAAACAAAGCTGCTGAAATCATCTTGAAAGTTTTGAACTCAGCTGTAGCT
AACGCTGAAAACAACTTTGGTTTGGATAAAGCTAACTTGGTAGTATCTGAAGCATTCGCA
AACGAAGGACCAACTATGAAACGTTTCCGTCCACGTGCGAAAGGTTCAGCTTCACCAATC
AACAAACGTACAGCTCACATCACTGTAGCTGTTGCAGAAAAATAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP61182
UniProtKB Entry NameRL22_STRPN
General References
  1. Adrian PV, Zhao W, Black TA, Shaw KJ, Hare RS, Klugman KP: Mutations in ribosomal protein L16 conferring reduced susceptibility to evernimicin (SCH27899): implications for mechanism of action. Antimicrob Agents Chemother. 2000 Mar;44(3):732-8. doi: 10.1128/aac.44.3.732-738.2000. [Article]
  2. Tettelin H, Nelson KE, Paulsen IT, Eisen JA, Read TD, Peterson S, Heidelberg J, DeBoy RT, Haft DH, Dodson RJ, Durkin AS, Gwinn M, Kolonay JF, Nelson WC, Peterson JD, Umayam LA, White O, Salzberg SL, Lewis MR, Radune D, Holtzapple E, Khouri H, Wolf AM, Utterback TR, Hansen CL, McDonald LA, Feldblyum TV, Angiuoli S, Dickinson T, Hickey EK, Holt IE, Loftus BJ, Yang F, Smith HO, Venter JC, Dougherty BA, Morrison DA, Hollingshead SK, Fraser CM: Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science. 2001 Jul 20;293(5529):498-506. [Article]
  3. Canu A, Malbruny B, Coquemont M, Davies TA, Appelbaum PC, Leclercq R: Diversity of ribosomal mutations conferring resistance to macrolides, clindamycin, streptogramin, and telithromycin in Streptococcus pneumoniae. Antimicrob Agents Chemother. 2002 Jan;46(1):125-31. doi: 10.1128/aac.46.1.125-131.2002. [Article]
  4. Perez-Trallero E, Marimon JM, Iglesias L, Larruskain J: Fluoroquinolone and macrolide treatment failure in pneumococcal pneumonia and selection of multidrug-resistant isolates. Emerg Infect Dis. 2003 Sep;9(9):1159-62. doi: 10.3201/eid0909.020810. [Article]
  5. Walsh F, Willcock J, Amyes S: High-level telithromycin resistance in laboratory-generated mutants of Streptococcus pneumoniae. J Antimicrob Chemother. 2003 Sep;52(3):345-53. doi: 10.1093/jac/dkg348. Epub 2003 Aug 13. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12825Lefamulinapproved, investigationalyesbinderDetails