60S ribosomal protein L23a

Details

Name
60S ribosomal protein L23a
Synonyms
Not Available
Gene Name
RPL23A
Organism
Humans
Amino acid sequence
>lcl|BSEQ0012667|60S ribosomal protein L23a
MAPKAKKEAPAPPKAEAKAKALKAKKAVLKGVHSHKKKKIRTSPTFRRPKTLRLRRQPKY
PRKSAPRRNKLDHYAIIKFPLTTESAMKKIEDNNTLVFIVDVKANKHQIKQAVKKLYDID
VAKVNTLIRPDGEKKAYVRLAPDYDALDVANKIGII
Number of residues
156
Molecular Weight
17694.885
Theoretical pI
11.16
GO Classification
Functions
nucleotide binding / poly(A) RNA binding / rRNA binding / structural constituent of ribosome
Processes
cell proliferation / cellular protein metabolic process / gene expression / nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / ribosomal large subunit assembly / SRP-dependent cotranslational protein targeting to membrane / translation / translational elongation / translational initiation / translational termination / viral life cycle / viral process / viral transcription
Components
cytoplasm / cytosol / cytosolic large ribosomal subunit / extracellular exosome / nucleolus / nucleus
General Function
Structural constituent of ribosome
Specific Function
This protein binds to a specific region on the 26S rRNA.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0012668|60S ribosomal protein L23a (RPL23A)
ATGGCGCCGAAAGCGAAGAAGGAAGCTCCTGCCCCTCCTAAAGCTGAAGCCAAAGCGAAG
GCTTTAAAGGCCAAGAAGGCAGTGTTGAAAGGTGTCCACAGCCACAAAAAGAAGAAGATC
CGCACGTCACCCACCTTCCGGCGGCCGAAGACACTGCGACTCCGGAGACAGCCCAAATAT
CCTCGGAAGAGCGCTCCCAGGAGAAACAAGCTTGACCACTATGCTATCATCAAGTTTCCG
CTGACCACTGAGTCTGCCATGAAGAAGATAGAAGACAACAACACACTTGTGTTCATTGTG
GATGTTAAAGCCAACAAGCACCAGATTAAACAGGCTGTGAAGAAGCTGTATGACATTGAT
GTGGCCAAGGTCAACACCCTGATTCGGCCTGATGGAGAGAAGAAGGCATATGTTCGACTG
GCTCCTGATTACGATGCTTTGGATGTTGCCAACAAAATTGGGATCATCTAA
Chromosome Location
17
Locus
17q11
External Identifiers
ResourceLink
UniProtKB IDP62750
UniProtKB Entry NameRL23A_HUMAN
GenBank Protein ID1399086
GenBank Gene IDU43701
HGNC IDHGNC:10317
General References
  1. Fan W, Cai W, Parimoo S, Schwarz DC, Lennon GG, Weissman SM: Identification of seven new human MHC class I region genes around the HLA-F locus. Immunogenetics. 1996;44(2):97-103. [PubMed:8662070]
  2. Fan W, Christensen M, Eichler E, Zhang X, Lennon G: Cloning, sequencing, gene organization, and localization of the human ribosomal protein RPL23A gene. Genomics. 1997 Dec 1;46(2):234-9. [PubMed:9417910]
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  5. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. [PubMed:17081983]
  6. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648]
  7. Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475. [PubMed:20068231]
  8. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [PubMed:21269460]
  9. Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal. 2011 Mar 15;4(164):rs3. doi: 10.1126/scisignal.2001570. [PubMed:21406692]
  10. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [PubMed:24275569]
  11. Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C: N-terminome analysis of the human mitochondrial proteome. Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8. [PubMed:25944712]
  12. Anger AM, Armache JP, Berninghausen O, Habeck M, Subklewe M, Wilson DN, Beckmann R: Structures of the human and Drosophila 80S ribosome. Nature. 2013 May 2;497(7447):80-5. doi: 10.1038/nature12104. [PubMed:23636399]
  13. Gazda HT, Preti M, Sheen MR, O'Donohue MF, Vlachos A, Davies SM, Kattamis A, Doherty L, Landowski M, Buros C, Ghazvinian R, Sieff CA, Newburger PE, Niewiadomska E, Matysiak M, Glader B, Atsidaftos E, Lipton JM, Gleizes PE, Beggs AH: Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia. Hum Mutat. 2012 Jul;33(7):1037-44. doi: 10.1002/humu.22081. Epub 2012 Apr 16. [PubMed:22431104]

Drug Relations

Drug Relations
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