Ras-related C3 botulinum toxin substrate 1

Details

Name
Ras-related C3 botulinum toxin substrate 1
Synonyms
  • Cell migration-inducing gene 5 protein
  • p21-Rac1
  • Ras-like protein TC25
  • TC25
Gene Name
RAC1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0002207|Ras-related C3 botulinum toxin substrate 1
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG
QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLR
DDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPP
PVKKRKRKCLLL
Number of residues
192
Molecular Weight
21449.895
Theoretical pI
8.65
GO Classification
Functions
enzyme binding / GTP binding / GTPase activity / Rho GDP-dissociation inhibitor binding / thioesterase binding
Processes
actin cytoskeleton organization / actin filament polymerization / anatomical structure morphogenesis / apoptotic signaling pathway / axon guidance / blood coagulation / cell adhesion / cell motility / cell-matrix adhesion / ephrin receptor signaling pathway / Fc-epsilon receptor signaling pathway / Fc-gamma receptor signaling pathway involved in phagocytosis / inflammatory response / innate immune response / intracellular signal transduction / lamellipodium assembly / localization within membrane / movement of cell or subcellular component / negative regulation of interleukin-23 production / negative regulation of receptor-mediated endocytosis / neurotrophin TRK receptor signaling pathway / platelet activation / positive regulation of apoptotic process / positive regulation of cell-substrate adhesion / positive regulation of focal adhesion assembly / positive regulation of lamellipodium assembly / positive regulation of neutrophil chemotaxis / positive regulation of protein phosphorylation / positive regulation of Rho protein signal transduction / positive regulation of stress fiber assembly / positive regulation of substrate adhesion-dependent cell spreading / regulation of cell migration / regulation of cell size / regulation of defense response to virus by virus / regulation of hydrogen peroxide metabolic process / regulation of respiratory burst / regulation of small GTPase mediated signal transduction / response to wounding / ruffle organization / semaphorin-plexin signaling pathway / small GTPase mediated signal transduction / substrate adhesion-dependent cell spreading / T cell costimulation / vascular endothelial growth factor receptor signaling pathway / viral process
Components
cytoplasm / cytoplasmic ribonucleoprotein granule / cytosol / endoplasmic reticulum membrane / extracellular exosome / focal adhesion / lamellipodium / melanosome / membrane / plasma membrane / trans-Golgi network
General Function
Thioesterase binding
Specific Function
Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0020506|Ras-related C3 botulinum toxin substrate 1 (RAC1)
ATGCAGGCCATCAAGTGTGTGGTGGTGGGAGACGGAGCTGTAGGTAAAACTTGCCTACTG
ATCAGTTACACAACCAATGCATTTCCTGGAGAATATATCCCTACTGTCTTTGACAATTAT
TCTGCCAATGTTATGGTAGATGGAAAACCGGTGAATCTGGGCTTATGGGATACAGCTGGA
CAAGAAGATTATGACAGATTACGCCCCCTATCCTATCCGCAAACAGATGTGTTCTTAATT
TGCTTTTCCCTTGTGAGTCCTGCATCATTTGAAAATGTCCGTGCAAAGTGGTATCCTGAG
GTGCGGCACCACTGTCCCAACACTCCCATCATCCTAGTGGGAACTAAACTTGATCTTAGG
GATGATAAAGACACGATCGAGAAACTGAAGGAGAAGAAGCTGACTCCCATCACCTATCCG
CAGGGTCTAGCCATGGCTAAGGAGATTGGTGCTGTAAAATACCTGGAGTGCTCGGCGCTC
ACACAGCGAGGCCTCAAGACAGTGTTTGACGAAGCGATCCGAGCAGTCCTCTGCCCGCCT
CCCGTGAAGAAGAGGAAGAGAAAATGCCTGCTGTTGTAA
Chromosome Location
7
Locus
7p22
External Identifiers
ResourceLink
UniProtKB IDP63000
UniProtKB Entry NameRAC1_HUMAN
GenBank Protein ID190824
GenBank Gene IDM29870
GenAtlas IDRAC1
HGNC IDHGNC:9801
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04315Guanosine-5'-DiphosphateexperimentalunknownDetails
DB00993AzathioprineapprovedunknownDetails
DB00514DextromethorphanapprovedunknowninhibitorDetails