Receptor of activated protein C kinase 1

Details

Name
Receptor of activated protein C kinase 1
Synonyms
  • Cell proliferation-inducing gene 21 protein
  • GNB2L1
  • Guanine nucleotide-binding protein subunit beta-2-like 1
  • Guanine nucleotide-binding protein subunit beta-like protein 12.3
  • HLC-7
  • Human lung cancer oncogene 7 protein
  • Receptor for activated C kinase
  • Small ribosomal subunit protein RACK1
Gene Name
RACK1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049650|Receptor of activated protein C kinase 1
MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR
GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI
VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA
NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALC
FSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA
GYTDNLVRVWQVTIGTR
Number of residues
317
Molecular Weight
35076.47
Theoretical pI
Not Available
GO Classification
Functions
cadherin binding / cysteine-type endopeptidase activator activity involved in apoptotic process / enzyme binding / ion channel inhibitor activity / protein complex scaffold / protein homodimerization activity / protein kinase C binding / protein phosphatase binding / protein tyrosine kinase inhibitor activity / receptor binding / receptor tyrosine kinase binding / ribosome binding / RNA binding / SH2 domain binding / signaling adaptor activity
Processes
activation of cysteine-type endopeptidase activity involved in apoptotic process / cell cycle / cellular response to glucose stimulus / cellular response to growth factor stimulus / gastrulation / negative regulation of cell growth / negative regulation of endoplasmic reticulum unfolded protein response / negative regulation of gene expression / negative regulation of hydrogen peroxide-induced neuron death / negative regulation of peptidyl-serine phosphorylation / negative regulation of phagocytosis / negative regulation of protein kinase B signaling / negative regulation of translation / negative regulation of Wnt signaling pathway / osteoblast differentiation / pigmentation / positive regulation of apoptotic process / positive regulation of cAMP catabolic process / positive regulation of cell migration / positive regulation of ceramide biosynthetic process / positive regulation of cyclic-nucleotide phosphodiesterase activity / positive regulation of gastrulation / positive regulation of Golgi to plasma membrane protein transport / positive regulation of GTPase activity / positive regulation of intrinsic apoptotic signaling pathway / positive regulation of mitochondrial depolarization / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / positive regulation of protein homooligomerization / positive regulation of protein phosphorylation / protein ubiquitination / regulation of cell cycle / regulation of cell division / regulation of establishment of cell polarity / regulation of protein localization / regulation of tumor necrosis factor-mediated signaling pathway / rescue of stalled ribosome / rhythmic process / viral process
Components
cytoplasm / cytosol / dendrite / extracellular exosome / IRE1-RACK1-PP2A complex / midbody / mitochondrion / neuronal cell body / nucleoplasm / nucleus / perikaryon / perinuclear region of cytoplasm / phagocytic cup / small ribosomal subunit
General Function
Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (PubMed:23636399). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (PubMed:28132843). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (PubMed:19674157). Promotes migration of breast carcinoma cells by binding to and activating RHOA (PubMed:20499158).
Specific Function
Cadherin binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0049651|Receptor of activated protein C kinase 1 (RACK1)
ATGACTGAGCAGATGACCCTTCGTGGCACCCTCAAGGGCCACAACGGCTGGGTAACCCAG
ATCGCTACTACCCCGCAGTTCCCGGACATGATCCTCTCCGCCTCTCGAGATAAGACCATC
ATCATGTGGAAACTGACCAGGGATGAGACCAACTATGGAATTCCACAGCGTGCTCTGCGG
GGTCACTCCCACTTTGTTAGTGATGTGGTTATCTCCTCAGATGGCCAGTTTGCCCTCTCA
GGCTCCTGGGATGGAACCCTGCGCCTCTGGGATCTCACAACGGGCACCACCACGAGGCGA
TTTGTGGGCCATACCAAGGATGTGCTGAGTGTGGCCTTCTCCTCTGACAACCGGCAGATT
GTCTCTGGATCTCGAGATAAAACCATCAAGCTATGGAATACCCTGGGTGTGTGCAAATAC
ACTGTCCAGGATGAGAGCCACTCAGAGTGGGTGTCTTGTGTCCGCTTCTCGCCCAACAGC
AGCAACCCTATCATCGTCTCCTGTGGCTGGGACAAGCTGGTCAAGGTATGGAACCTGGCT
AACTGCAAGCTGAAGACCAACCACATTGGCCACACAGGCTATCTGAACACGGTGACTGTC
TCTCCAGATGGATCCCTCTGTGCTTCTGGAGGCAAGGATGGCCAGGCCATGTTATGGGAT
CTCAACGAAGGCAAACACCTTTACACGCTAGATGGTGGGGACATCATCAACGCCCTGTGC
TTCAGCCCTAACCGCTACTGGCTGTGTGCTGCCACAGGCCCCAGCATCAAGATCTGGGAT
TTAGAGGGAAAGATCATTGTAGATGAACTGAAGCAAGAAGTTATCAGTACCAGCAGCAAG
GCAGAACCACCCCAGTGCACCTCCCTGGCCTGGTCTGCTGATGGCCAGACTCTGTTTGCT
GGCTACACGGACAACCTGGTGCGAGTGTGGCAGGTGACCATTGGCACACGCTAG
Chromosome Location
5
Locus
5q35.3
External Identifiers
ResourceLink
UniProtKB IDP63244
UniProtKB Entry NameRACK1_HUMAN
HGNC IDHGNC:4399
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB09130Copperapproved, investigationalunknownDetails