Free methionine-R-sulfoxide reductase
Details
- Name
- Free methionine-R-sulfoxide reductase
- Synonyms
- 1.8.4.14
- fRMsr
- yebR
- Gene Name
- msrC
- Organism
- Escherichia coli (strain K12)
- Amino acid sequence
>lcl|BSEQ0037222|Free methionine-R-sulfoxide reductase MNKTEFYADLNRDFNALMAGETSFLATLANTSALLYERLTDINWAGFYLLEDDTLVLGPF QGKIACVRIPVGRGVCGTAVARNQVQRIEDVHVFDGHIACDAASNSEIVLPLVVKNQIIG VLDIDSTVFGRFTDEDEQGLRQLVAQLEKVLATTDYKKFFASVAG
- Number of residues
- 165
- Molecular Weight
- 18121.45
- Theoretical pI
- 4.45
- GO Classification
- FunctionsL-methionine-(R)-S-oxide reductase activity / oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptorProcessesresponse to oxidative stressComponentscytosol
- General Function
- Oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
- Specific Function
- Catalyzes the reversible oxidation-reduction of the R-enantiomer of free methionine sulfoxide to methionine. Specific for free L-methionine-(R)-S-oxide.
- Pfam Domain Function
- GAF_2 (PF13185)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0012222|Free methionine-R-sulfoxide reductase (msrC) ATGCTTATTTTAATAGGCTGGCAGATCCAGGTAAGACAACCAAGTGATTATATAATGAAC AAAACAGAATTTTACGCGGATTTAAATCGCGACTTTAACGCGCTGATGGCGGGAGAAACC AGTTTTCTGGCAACGCTTGCGAACACCAGTGCGTTGTTATATGAGCGTCTCACTGACATA AACTGGGCAGGTTTTTATTTGCTTGAGGACGATACACTGGTACTCGGACCATTTCAGGGC AAAATTGCCTGTGTCCGGATACCCGTCGGGCGCGGCGTGTGCGGCACTGCGGTTGCCCGC AATCAAGTGCAGCGTATCGAGGATGTTCATGTGTTTGACGGGCATATTGCCTGTGATGCG GCGAGTAATTCTGAAATTGTTCTGCCGCTGGTGGTGAAAAATCAGATTATTGGTGTTCTC GACATCGATAGTACCGTCTTCGGTCGCTTTACAGACGAGGACGAGCAAGGCTTACGTCAG CTTGTGGCACAGCTTGAAAAAGTGCTTGCAACGACGGATTACAAAAAATTCTTTGCGAGC GTCGCAGGATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P76270 UniProtKB Entry Name MSRC_ECOLI GenBank Gene ID U00096 - General References
- Itoh T, Aiba H, Baba T, Hayashi K, Inada T, Isono K, Kasai H, Kimura S, Kitakawa M, Kitagawa M, Makino K, Miki T, Mizobuchi K, Mori H, Mori T, Motomura K, Nakade S, Nakamura Y, Nashimoto H, Nishio Y, Oshima T, Saito N, Sampei G, Seki Y, Horiuchi T, et al.: A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map. DNA Res. 1996 Dec 31;3(6):379-92. [Article]
- Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
- Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]
- Fountoulakis M, Takacs MF, Berndt P, Langen H, Takacs B: Enrichment of low abundance proteins of Escherichia coli by hydroxyapatite chromatography. Electrophoresis. 1999 Aug;20(11):2181-95. [Article]
- Lin Z, Johnson LC, Weissbach H, Brot N, Lively MO, Lowther WT: Free methionine-(R)-sulfoxide reductase from Escherichia coli reveals a new GAF domain function. Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9597-602. Epub 2007 May 29. [Article]
- Badger J, Sauder JM, Adams JM, Antonysamy S, Bain K, Bergseid MG, Buchanan SG, Buchanan MD, Batiyenko Y, Christopher JA, Emtage S, Eroshkina A, Feil I, Furlong EB, Gajiwala KS, Gao X, He D, Hendle J, Huber A, Hoda K, Kearins P, Kissinger C, Laubert B, Lewis HA, Lin J, Loomis K, Lorimer D, Louie G, Maletic M, Marsh CD, Miller I, Molinari J, Muller-Dieckmann HJ, Newman JM, Noland BW, Pagarigan B, Park F, Peat TS, Post KW, Radojicic S, Ramos A, Romero R, Rutter ME, Sanderson WE, Schwinn KD, Tresser J, Winhoven J, Wright TA, Wu L, Xu J, Harris TJ: Structural analysis of a set of proteins resulting from a bacterial genomics project. Proteins. 2005 Sep 1;60(4):787-96. [Article]