Pyridoxamine kinase
Details
- Name
- Pyridoxamine kinase
- Synonyms
- 2.7.1.35
- PM kinase
- ydgS
- Gene Name
- pdxY
- Organism
- Escherichia coli (strain K12)
- Amino acid sequence
>lcl|BSEQ0019122|Pyridoxamine kinase MMKNILAIQSHVVYGHAGNSAAEFPMRRLGANVWPLNTVQFSNHTQYGKWTGCVMPPSHL TEIVQGIAAIDKLHTCDAVLSGYLGSAEQGEHILGIVRQVKAANPQAKYFCDPVMGHPEK GCIVAPGVAEFHVRHGLPASDIIAPNLVELEILCEHAVNNVEEAVLAARELIAQGPQIVL VKHLARAGYSRDRFEMLLVTADEAWHISRPLVDFGMRQPVGVGDVTSGLLLVKLLQGATL QEALEHVTAAVYEIMVTTKAMQEYELQVVAAQDRIAKPEHYFSATKL
- Number of residues
- 287
- Molecular Weight
- 31322.01
- Theoretical pI
- 6.5
- GO Classification
- FunctionsATP binding / glucokinase activity / identical protein binding / pyridoxal kinase activity / zinc ion bindingProcessesglycolytic process / pyridoxal 5'-phosphate salvage / pyridoxal metabolic process / vitamin B6 biosynthetic processComponentscytosol
- General Function
- Zinc ion binding
- Specific Function
- Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxamine, but has negligible activity toward pyridoxal and pyridoxine as substrates.
- Pfam Domain Function
- Phos_pyr_kin (PF08543)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0019123|Pyridoxamine kinase (pdxY) ATGATGAAAAATATTCTCGCTATCCAGTCTCACGTTGTTTATGGTCATGCGGGTAACAGT GCGGCAGAGTTTCCGATGCGCCGCCTGGGCGCGAACGTCTGGCCGCTGAACACCGTTCAA TTTTCTAATCACACCCAATACGGCAAATGGACTGGCTGCGTGATGCCGCCCAGCCATTTA ACCGAAATTGTGCAAGGCATTGCCGCCATTGATAAATTACACACCTGTGATGCCGTATTA AGTGGCTATCTGGGATCGGCGGAGCAGGGTGAACATATCCTCGGTATCGTCCGTCAGGTG AAAGCCGCGAATCCGCAGGCGAAATATTTTTGCGATCCGGTAATGGGTCATCCGGAAAAA GGCTGTATCGTTGCACCGGGTGTCGCAGAGTTTCATGTGCGGCACGGTTTGCCTGCCAGC GATATCATTGCGCCAAATCTGGTTGAGCTGGAAATACTCTGTGAGCATGCGGTAAATAAC GTCGAAGAAGCGGTTCTGGCAGCGCGCGAACTCATTGCGCAAGGGCCACAAATTGTGTTG GTTAAACACCTGGCGCGAGCTGGCTACAGCCGTGACCGTTTTGAAATGCTGCTGGTCACC GCCGATGAAGCCTGGCATATCAGCCGTCCGCTGGTGGATTTTGGTATGCGCCAGCCGGTA GGTGTTGGTGATGTGACGAGCGGTTTACTGCTGGTGAAACTGCTTCAGGGGGCAACGCTG CAGGAGGCGCTGGAACATGTGACCGCTGCAGTCTACGAAATCATGGTGACCACCAAAGCA ATGCAGGAATATGAGCTGCAAGTGGTGGCTGCTCAGGATCGTATTGCCAAACCAGAACAT TACTTCAGCGCAACAAAGCTCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P77150 UniProtKB Entry Name PDXY_ECOLI GenBank Protein ID 1787924 GenBank Gene ID U00096 - General References
- Aiba H, Baba T, Hayashi K, Inada T, Isono K, Itoh T, Kasai H, Kashimoto K, Kimura S, Kitakawa M, Kitagawa M, Makino K, Miki T, Mizobuchi K, Mori H, Mori T, Motomura K, Nakade S, Nakamura Y, Nashimoto H, Nishio Y, Oshima T, Saito N, Sampei G, Horiuchi T, et al.: A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map. DNA Res. 1996 Dec 31;3(6):363-77. [Article]
- Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
- Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]
- Yang Y, Tsui HC, Man TK, Winkler ME: Identification and function of the pdxY gene, which encodes a novel pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate biosynthesis in Escherichia coli K-12. J Bacteriol. 1998 Apr;180(7):1814-21. [Article]
- Safo MK, Musayev FN, Hunt S, di Salvo ML, Scarsdale N, Schirch V: Crystal structure of the PdxY Protein from Escherichia coli. J Bacteriol. 2004 Dec;186(23):8074-82. [Article]