30S ribosomal protein S2

Details

Name
30S ribosomal protein S2
Synonyms
  • rps2
Gene Name
rpsB
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Amino acid sequence
>lcl|BSEQ0017372|30S ribosomal protein S2
MPVEITVKELLEAGVHFGHERKRWNPKFARYIYAERNGIHIIDLQKTMEELERTFRFIED
LAMRGGTILFVGTKKQAQDIVRMEAERAGMPYVNQRWLGGMLTNFKTISQRVHRLEELEA
LFASPEIEERPKKEQVRLKHELERLQKYLSGFRLLKRLPDAIFVVDPTKEAIAVREARKL
FIPVIALADTDSDPDLVDYIIPGNDDAIRSIQLILSRAVDLIIQARGGVVEPSPSYALVQ
EAEATETPEGESEVEA
Number of residues
256
Molecular Weight
29276.395
Theoretical pI
5.3
GO Classification
Functions
rRNA binding / structural constituent of ribosome
Processes
translation
Components
small ribosomal subunit
General Function
Structural constituent of ribosome
Specific Function
Spans the head-body hinge region of the 30S subunit. Is loosely associated with the 30S subunit.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0017373|30S ribosomal protein S2 (rpsB)
ATGCCCGTAGAGATCACGGTTAAGGAGCTCCTGGAAGCCGGTGTCCACTTCGGCCACGAG
AGGAAGCGCTGGAACCCCAAGTTCGCCCGCTACATCTACGCGGAGCGGAACGGCATCCAC
ATCATTGACCTCCAGAAGACCATGGAGGAGCTGGAGCGCACGTTCCGCTTCATTGAGGAC
CTGGCCATGCGCGGCGGGACGATCCTCTTCGTGGGGACCAAGAAGCAGGCCCAGGACATC
GTGCGCATGGAGGCGGAGCGTGCGGGCATGCCCTATGTGAACCAGCGCTGGCTCGGCGGC
ATGCTCACCAACTTCAAGACCATCTCCCAGCGGGTCCACCGGCTGGAGGAGCTGGAGGCC
CTCTTCGCCTCCCCGGAGATTGAGGAGCGCCCCAAGAAGGAGCAGGTCCGGCTGAAGCAC
GAGCTGGAACGGCTTCAGAAGTACCTCTCCGGCTTCCGCCTCCTGAAGCGCCTCCCCGAC
GCCATCTTCGTCGTGGATCCGACCAAGGAGGCCATCGCCGTCCGGGAGGCGAGGAAGCTC
TTCATCCCCGTGATCGCCCTGGCGGACACGGACTCCGACCCCGACCTGGTGGACTACATC
ATCCCCGGCAACGACGACGCCATCCGCTCCATCCAGCTCATCCTCTCCCGGGCGGTGGAC
CTCATCATCCAGGCCCGGGGCGGGGTGGTGGAGCCCTCCCCCTCCTACGCCCTGGTGCAG
GAGGCGGAAGCCACCGAGACGCCCGAGGGCGAAAGCGAGGTGGAAGCATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP80371
UniProtKB Entry NameRS2_THET8
GenBank Protein ID55771383
GenBank Gene IDAP008226
General References
  1. Tsiboli P, Herfurth E, Choli T: Purification and characterization of the 30S ribosomal proteins from the bacterium Thermus thermophilus. Eur J Biochem. 1994 Nov 15;226(1):169-77. [Article]
  2. Blank J, Nock S, Kreutzer R, Sprinzl M: Elongation factor Ts from Thermus thermophilus-- overproduction in Escherichia coli, quaternary structure and interaction with elongation factor Tu. Eur J Biochem. 1996 Feb 15;236(1):222-7. [Article]
  3. Wimberly BT, Brodersen DE, Clemons WM Jr, Morgan-Warren RJ, Carter AP, Vonrhein C, Hartsch T, Ramakrishnan V: Structure of the 30S ribosomal subunit. Nature. 2000 Sep 21;407(6802):327-39. [Article]
  4. Schluenzen F, Tocilj A, Zarivach R, Harms J, Gluehmann M, Janell D, Bashan A, Bartels H, Agmon I, Franceschi F, Yonath A: Structure of functionally activated small ribosomal subunit at 3.3 angstroms resolution. Cell. 2000 Sep 1;102(5):615-23. [Article]
  5. Brodersen DE, Clemons WM Jr, Carter AP, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V: The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit. Cell. 2000 Dec 22;103(7):1143-54. [Article]
  6. Carter AP, Clemons WM, Brodersen DE, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V: Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature. 2000 Sep 21;407(6802):340-8. [Article]
  7. Yusupova GZ, Yusupov MM, Cate JH, Noller HF: The path of messenger RNA through the ribosome. Cell. 2001 Jul 27;106(2):233-41. [Article]
  8. Pioletti M, Schlunzen F, Harms J, Zarivach R, Gluhmann M, Avila H, Bashan A, Bartels H, Auerbach T, Jacobi C, Hartsch T, Yonath A, Franceschi F: Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3. EMBO J. 2001 Apr 17;20(8):1829-39. [Article]
  9. Carter AP, Clemons WM Jr, Brodersen DE, Morgan-Warren RJ, Hartsch T, Wimberly BT, Ramakrishnan V: Crystal structure of an initiation factor bound to the 30S ribosomal subunit. Science. 2001 Jan 19;291(5503):498-501. [Article]
  10. Yusupov MM, Yusupova GZ, Baucom A, Lieberman K, Earnest TN, Cate JH, Noller HF: Crystal structure of the ribosome at 5.5 A resolution. Science. 2001 May 4;292(5518):883-96. Epub 2001 Mar 29. [Article]
  11. Ogle JM, Brodersen DE, Clemons WM Jr, Tarry MJ, Carter AP, Ramakrishnan V: Recognition of cognate transfer RNA by the 30S ribosomal subunit. Science. 2001 May 4;292(5518):897-902. [Article]
  12. Brodersen DE, Clemons WM Jr, Carter AP, Wimberly BT, Ramakrishnan V: Crystal structure of the 30 S ribosomal subunit from Thermus thermophilus: structure of the proteins and their interactions with 16 S RNA. J Mol Biol. 2002 Feb 22;316(3):725-68. [Article]
  13. Sharma MR, Barat C, Wilson DN, Booth TM, Kawazoe M, Hori-Takemoto C, Shirouzu M, Yokoyama S, Fucini P, Agrawal RK: Interaction of Era with the 30S ribosomal subunit implications for 30S subunit assembly. Mol Cell. 2005 Apr 29;18(3):319-29. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB081852-METHYLTHIO-N6-ISOPENTENYL-ADENOSINE-5'-MONOPHOSPHATEexperimentalunknownDetails