Kynureninase

Details

Name
Kynureninase
Synonyms
  • 3.7.1.3
  • L-kynurenine hydrolase
Gene Name
kynU
Organism
Pseudomonas fluorescens
Amino acid sequence
>lcl|BSEQ0011926|Kynureninase
MTTRNDCLALDAQDSLAPLRQQFALPEGVIYLDGNSLGARPVAALARAQAVIAEEWGNGL
IRSWNSAGWRDLSERLGNRLATLIGARDGEVVVTDTTSINLFKVLSAALRVQATRSPERR
VIVTETSNFPTDLYIAEGLADMLQQGYTLRLVDSPEELPQAIDQDTAVVMLTHVNYKTGY
MHDMQALTALSHECGALAIWDLAHSAGAVPVDLHQAGADYAIGCTYKYLNGGPGSQAFVW
VSPQLCDLVPQPLSGWFGHSRQFAMEPRYEPSNGIARYLCGTQPITSLAMVECGLDVFAQ
TDMASLRRKSLALTDLFIELVEQRCAAHELTLVTPREHAKRGSHVSFEHPEGYAVIQALI
DRGVIGDYREPRIMRFGFTPLYTTFTEVWDAVQILGEILDRKTWAQAQFQVRHSVT
Number of residues
416
Molecular Weight
45904.725
Theoretical pI
5.25
GO Classification
Functions
kynureninase activity / pyridoxal phosphate binding
Processes
'de novo' NAD biosynthetic process from tryptophan / anthranilate metabolic process / L-kynurenine catabolic process / quinolinate biosynthetic process / tryptophan catabolic process
Components
cytoplasm
General Function
Pyridoxal phosphate binding
Specific Function
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP83788
UniProtKB Entry NameKYNU_PSEFL
General References
  1. Momany C, Levdikov V, Blagova L, Lima S, Phillips RS: Three-dimensional structure of kynureninase from Pseudomonas fluorescens. Biochemistry. 2004 Feb 10;43(5):1193-203. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB023433,6,9,12,15-PentaoxaheptadecaneexperimentalunknownDetails