Kynureninase
Details
- Name
- Kynureninase
- Synonyms
- 3.7.1.3
- L-kynurenine hydrolase
- Gene Name
- kynU
- Organism
- Pseudomonas fluorescens
- Amino acid sequence
>lcl|BSEQ0011926|Kynureninase MTTRNDCLALDAQDSLAPLRQQFALPEGVIYLDGNSLGARPVAALARAQAVIAEEWGNGL IRSWNSAGWRDLSERLGNRLATLIGARDGEVVVTDTTSINLFKVLSAALRVQATRSPERR VIVTETSNFPTDLYIAEGLADMLQQGYTLRLVDSPEELPQAIDQDTAVVMLTHVNYKTGY MHDMQALTALSHECGALAIWDLAHSAGAVPVDLHQAGADYAIGCTYKYLNGGPGSQAFVW VSPQLCDLVPQPLSGWFGHSRQFAMEPRYEPSNGIARYLCGTQPITSLAMVECGLDVFAQ TDMASLRRKSLALTDLFIELVEQRCAAHELTLVTPREHAKRGSHVSFEHPEGYAVIQALI DRGVIGDYREPRIMRFGFTPLYTTFTEVWDAVQILGEILDRKTWAQAQFQVRHSVT
- Number of residues
- 416
- Molecular Weight
- 45904.725
- Theoretical pI
- 5.25
- GO Classification
- Functionskynureninase activity / pyridoxal phosphate bindingProcesses'de novo' NAD biosynthetic process from tryptophan / anthranilate metabolic process / L-kynurenine catabolic process / quinolinate biosynthetic process / tryptophan catabolic processComponentscytoplasm
- General Function
- Pyridoxal phosphate binding
- Specific Function
- Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
- Pfam Domain Function
- Aminotran_5 (PF00266)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P83788 UniProtKB Entry Name KYNU_PSEFL - General References
- Momany C, Levdikov V, Blagova L, Lima S, Phillips RS: Three-dimensional structure of kynureninase from Pseudomonas fluorescens. Biochemistry. 2004 Feb 10;43(5):1193-203. [Article]