ADP-ribosylation factor 1

Details

Name
ADP-ribosylation factor 1
Synonyms
Not Available
Gene Name
ARF1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0020712|ADP-ribosylation factor 1
MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKN
ISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAV
LLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLSNQLRNQ
K
Number of residues
181
Molecular Weight
20696.62
Theoretical pI
6.8
GO Classification
Functions
GDP binding / GTP binding / GTPase activity / magnesium ion binding / phospholipase D activator activity / poly(A) RNA binding / receptor signaling protein activity
Processes
actin filament organization / antigen processing and presentation of exogenous peptide antigen via MHC class II / cellular copper ion homeostasis / COPI coating of Golgi vesicle / dendritic spine organization / Golgi to transport vesicle transport / long term synaptic depression / lysosomal membrane organization / membrane organization / phosphatidylinositol biosynthetic process / phospholipid metabolic process / positive regulation of calcium ion-dependent exocytosis / positive regulation of dendritic spine development / positive regulation of endocytosis / positive regulation of ER to Golgi vesicle-mediated transport / positive regulation of late endosome to lysosome transport / positive regulation of protein secretion / positive regulation of sodium ion transmembrane transport / post-Golgi vesicle-mediated transport / protein transport / regulation of Arp2/3 complex-mediated actin nucleation / regulation of defense response to virus by virus / regulation of phospholipid metabolic process / regulation of receptor internalization / retrograde vesicle-mediated transport, Golgi to ER / small GTPase mediated signal transduction / small molecule metabolic process / synaptic vesicle budding / very-low-density lipoprotein particle assembly / viral process
Components
cell leading edge / COPI-coated vesicle / cytosol / extracellular exosome / focal adhesion / Golgi membrane / late endosome / neuron projection / perinuclear region of cytoplasm / peroxisomal membrane / plasma membrane / postsynaptic density / postsynaptic membrane / sarcomere / trans-Golgi network
General Function
Receptor signaling protein activity
Specific Function
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Golgi apparatus
Gene sequence
>lcl|BSEQ0020713|ADP-ribosylation factor 1 (ARF1)
ATGGGGAACATCTTCGCCAACCTCTTCAAGGGCCTTTTTGGCAAAAAAGAAATGCGCATC
CTCATGGTGGGCCTGGATGCTGCAGGGAAGACCACGATCCTCTACAAGCTTAAGCTGGGT
GAGATCGTGACCACCATTCCCACCATAGGCTTCAACGTGGAAACCGTGGAGTACAAGAAC
ATCAGCTTCACTGTGTGGGACGTGGGTGGCCAGGACAAGATCCGGCCCCTGTGGCGCCAC
TACTTCCAGAACACACAAGGCCTGATCTTCGTGGTGGACAGCAATGACAGAGAGCGTGTG
AACGAGGCCCGTGAGGAGCTCATGAGGATGCTGGCCGAGGACGAGCTCCGGGATGCTGTC
CTCCTGGTGTTCGCCAACAAGCAGGACCTCCCCAACGCCATGAATGCGGCCGAGATCACA
GACAAGCTGGGGCTGCACTCACTACGCCACAGGAACTGGTACATTCAGGCCACCTGCGCC
ACCAGCGGCGACGGGCTCTATGAAGGACTGGACTGGCTGTCCAATCAGCTCCGGAACCAG
AAGTGA
Chromosome Location
1
Locus
1q42
External Identifiers
ResourceLink
UniProtKB IDP84077
UniProtKB Entry NameARF1_HUMAN
GenBank Protein ID178983
GenBank Gene IDM36340
HGNC IDHGNC:652
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB027741,3-PropanediolexperimentalunknownDetails
DB09462Glycerinapproved, investigationalunknownDetails
DB04121Guanosine-3'-monophosphate-5'-diphosphateexperimentalunknownDetails
DB04137Guanosine-5'-TriphosphateexperimentalunknownDetails
DB04315Guanosine-5'-DiphosphateexperimentalunknownDetails
DB07348Brefeldin AexperimentalunknownDetails
DB08231Myristic acidexperimentalunknownDetails