Nicotinate-nucleotide pyrophosphorylase [carboxylating]
Details
- Name
- Nicotinate-nucleotide pyrophosphorylase [carboxylating]
- Synonyms
- 2.4.2.19
- QAPRTase
- Quinolinate phosphoribosyltransferase [decarboxylating]
- Gene Name
- nadC
- Organism
- Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
- Amino acid sequence
>lcl|BSEQ0051199|Nicotinate-nucleotide pyrophosphorylase [carboxylating] MGLSDWELAAARAAIARGLDEDLRYGPDVTTLATVPASATTTASLVTREAGVVAGLDVAL LTLNEVLGTNGYRVLDRVEDGARVPPGEALMTLEAQTRGLLTAERTMLNLVGHLSGIATA TAAWVDAVRGTKAKIRDTRKTLPGLRALQKYAVRTGGGVNHRLGLGDAALIKDNHVAAAG SVVDALRAVRNAAPDLPCEVEVDSLEQLDAVLPEKPELILLDNFAVWQTQTAVQRRDSRA PTVMLESSGGLSLQTAATYAETGVDYLAVGALTHSVRVLDIGLDM
- Number of residues
- 285
- Molecular Weight
- 29950.79
- Theoretical pI
- Not Available
- GO Classification
- Functionsnicotinate-nucleotide diphosphorylase (carboxylating) activityProcessesNAD biosynthetic process / quinolinate catabolic processComponentscell wall / cytoplasm / plasma membrane
- General Function
- Involved in the catabolism of quinolinic acid (QA).
- Specific Function
- Nicotinate-nucleotide diphosphorylase (carboxylating) activity
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0051200|Nicotinate-nucleotide pyrophosphorylase [carboxylating] (nadC) ATGGGGTTATCCGACTGGGAGCTGGCTGCGGCTCGAGCAGCAATCGCGCGTGGGCTCGAC GAGGACCTCCGGTACGGCCCGGATGTCACCACATTGGCGACGGTGCCTGCCAGTGCGACG ACCACCGCATCGCTGGTGACCCGGGAGGCCGGTGTGGTTGCCGGATTGGATGTCGCGCTG CTGACGCTGAACGAAGTCCTGGGCACCAACGGTTATCGGGTGCTCGACCGCGTCGAGGAC GGCGCCCGGGTGCCGCCGGGAGAGGCACTTATGACGCTGGAAGCCCAAACGCGCGGATTG TTGACCGCCGAGCGCACCATGTTGAACCTGGTCGGTCACCTGTCGGGAATCGCCACCGCG ACGGCCGCGTGGGTCGATGCTGTGCGCGGGACCAAAGCGAAAATCCGCGATACCCGTAAG ACGCTGCCCGGCCTGCGCGCGCTGCAAAAATACGCGGTGCGTACCGGTGGCGGCGTCAAC CATCGGCTGGGGTTGGGTGATGCCGCGCTAATCAAGGACAACCACGTTGCCGCCGCCGGA TCCGTGGTAGACGCGCTACGTGCGGTGCGAAATGCTGCACCCGATCTGCCGTGCGAGGTG GAAGTGGACTCGCTTGAGCAGCTCGATGCCGTGCTGCCGGAAAAACCCGAGCTGATCCTG CTGGACAATTTTGCGGTGTGGCAGACGCAGACCGCGGTGCAGCGTCGGGACTCGCGCGCG CCCACCGTCATGCTGGAGTCATCCGGTGGGCTCAGCCTGCAGACGGCGGCGACCTACGCC GAAACCGGGGTGGACTACCTGGCGGTCGGGGCGCTCACACACTCAGTGCGCGTGCTCGAC ATCGGCTTGGATATGTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P9WJJ7 UniProtKB Entry Name NADC_MYCTU - General References
- Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
- Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]
- Sharma V, Grubmeyer C, Sacchettini JC: Crystal structure of quinolinic acid phosphoribosyltransferase from Mmycobacterium tuberculosis: a potential TB drug target. Structure. 1998 Dec 15;6(12):1587-99. [Article]