D-3-phosphoglycerate dehydrogenase

Details

Name
D-3-phosphoglycerate dehydrogenase
Synonyms
  • 1.1.1.95
  • 2-oxoglutarate reductase
  • PGDH
Gene Name
serA
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Amino acid sequence
>lcl|BSEQ0051136|D-3-phosphoglycerate dehydrogenase
MSLPVVLIADKLAPSTVAALGDQVEVRWVDGPDRDKLLAAVPEADALLVRSATTVDAEVL
AAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHSAAEHALALLLAASRQIPAA
DASLREHTWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRIAAFGAYVVAYDPYVSPARAA
QLGIELLSLDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAA
LADAITGGHVRAAGLDVFATEPCTDSPLFELAQVVVTPHLGASTAEAQDRAGTDVAESVR
LALAGEFVPDAVNVGGGVVNEEVAPWLDLVRKLGVLAGVLSDELPVSLSVQVRGELAAEE
VEVLRLSALRGLFSAVIEDAVTFVNAPALAAERGVTAEICKASESPNHRSVVDVRAVGAD
GSVVTVSGTLYGPQLSQKIVQINGRHFDLRAQGINLIIHYVDRPGALGKIGTLLGTAGVN
IQAAQLSEDAEGPGATILLRLDQDVPDDVRTAIAAAVDAYKLEVVDLS
Number of residues
528
Molecular Weight
54553.635
Theoretical pI
Not Available
GO Classification
Functions
NAD binding / phosphoglycerate dehydrogenase activity
Processes
growth / L-serine biosynthetic process
Components
cell wall / plasma membrane
General Function
Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.
Specific Function
Nad binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0051137|D-3-phosphoglycerate dehydrogenase (serA)
GTGAGCCTGCCTGTTGTGTTGATCGCCGACAAACTTGCCCCATCAACGGTTGCCGCCTTG
GGAGATCAGGTCGAGGTGCGCTGGGTTGACGGTCCGGACCGAGACAAGCTGCTGGCCGCG
GTGCCCGAAGCGGACGCGCTGCTGGTGCGATCGGCCACCACGGTTGACGCCGAGGTGCTG
GCCGCCGCCCCCAAGCTCAAGATCGTCGCGCGCGCCGGCGTCGGGCTGGACAACGTCGAC
GTGGACGCCGCGACGGCCCGCGGCGTGCTGGTGGTCAACGCCCCGACGTCGAACATCCAC
AGCGCCGCGGAGCATGCGCTGGCGCTGCTGCTGGCCGCCTCACGCCAGATTCCGGCGGCC
GACGCGTCGCTGCGCGAGCACACCTGGAAGCGTTCGTCGTTTTCCGGTACCGAGATCTTC
GGCAAAACCGTCGGCGTGGTGGGTCTGGGCCGCATCGGGCAGTTGGTCGCCCAGCGGATC
GCTGCGTTCGGCGCTTACGTCGTCGCCTATGACCCGTACGTTTCGCCGGCCCGTGCGGCG
CAGCTGGGCATCGAACTGCTGTCCCTGGACGACCTGCTGGCCCGCGCCGATTTCATCTCG
GTGCACCTACCGAAAACACCGGAGACGGCGGGACTGATCGACAAGGAGGCGCTGGCGAAG
ACCAAGCCGGGCGTCATCATCGTCAACGCCGCGCGCGGCGGCCTGGTGGACGAGGCGGCA
CTGGCCGACGCGATCACCGGCGGCCACGTGCGGGCGGCCGGTCTGGACGTGTTCGCCACC
GAACCGTGCACCGACAGCCCGCTGTTCGAGCTGGCACAGGTGGTGGTCACACCGCATCTG
GGTGCGTCCACCGCGGAGGCGCAGGACCGGGCGGGCACCGACGTCGCCGAGAGCGTGCGG
CTGGCCCTGGCAGGGGAATTCGTGCCCGACGCGGTCAACGTCGGCGGCGGAGTGGTCAAC
GAGGAGGTGGCGCCCTGGCTGGATCTGGTGCGTAAGCTCGGCGTGCTGGCGGGTGTGTTG
TCCGACGAACTGCCGGTGTCGTTGTCGGTGCAGGTGCGCGGTGAGCTGGCCGCCGAAGAG
GTTGAGGTGCTGCGCCTTTCGGCGCTGCGCGGCCTGTTCTCGGCGGTGATCGAGGATGCG
GTGACATTTGTCAACGCACCGGCATTGGCCGCCGAACGTGGCGTCACCGCCGAGATCTGT
AAGGCCTCGGAAAGCCCCAACCACCGCAGCGTCGTCGACGTTCGCGCGGTCGGCGCGGAC
GGTTCGGTGGTGACCGTCTCGGGCACGCTGTATGGCCCACAGCTGTCGCAGAAGATCGTG
CAGATCAACGGCCGCCACTTTGATCTGCGCGCCCAGGGGATCAACCTGATCATCCACTAC
GTCGACCGGCCGGGAGCGCTGGGCAAGATCGGCACGTTGCTGGGGACGGCCGGGGTGAAT
ATCCAGGCCGCGCAGCTCTCCGAAGACGCCGAAGGCCCGGGCGCGACGATTCTGCTGCGG
CTGGACCAAGACGTGCCCGACGACGTGCGGACGGCGATCGCGGCGGCGGTGGACGCCTAC
AAGCTCGAGGTTGTCGATCTGTCGTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP9WNX3
UniProtKB Entry NameSERA_MYCTU
General References
  1. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
  2. Raman K, Yeturu K, Chandra N: targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis. BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109. [Article]
  3. Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01694D-tartaric acidexperimentalunknownDetails