Cyclopropane mycolic acid synthase 1
Details
- Name
- Cyclopropane mycolic acid synthase 1
- Synonyms
- 2.1.1.79
- AdoMet-MT
- CFA synthase
- cma1
- CMAS
- CMAS-1
- Cyclopropane fatty acid synthase
- Cyclopropane-fatty-acyl-phospholipid synthase
- MA-MT
- Mycolic acid methyltransferase
- S-adenosylmethionine-dependent methyltransferase
- SAM-MT
- Gene Name
- cmaA1
- Organism
- Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
- Amino acid sequence
>lcl|BSEQ0051219|Cyclopropane mycolic acid synthase 1 MPDELKPHFANVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMTLQEAQIAKIDLALGKL GLQPGMTLLDVGCGWGATMMRAVEKYDVNVVGLTLSKNQANHVQQLVANSENLRSKRVLL AGWEQFDEPVDRIVSIGAFEHFGHERYDAFFSLAHRLLPADGVMLLHTITGLHPKEIHER GLPMSFTFARFLKFIVTEIFPGGRLPSIPMVQECASANGFTVTRVQSLQPHYAKTLDLWS AALQANKGQAIALQSEEVYERYMKYLTGCAEMFRIGYIDVNQFTCQK
- Number of residues
- 287
- Molecular Weight
- 32460.98
- Theoretical pI
- Not Available
- GO Classification
- Functionscyclopropane-fatty-acyl-phospholipid synthase activityProcesseslipid biosynthetic process / mycolic acid biosynthetic process / S-adenosylmethionine metabolic processComponentscytoplasm / plasma membrane
- General Function
- Catalyzes the conversion of a double bond to a cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence.
- Specific Function
- Cyclopropane-fatty-acyl-phospholipid synthase activity
- Pfam Domain Function
- CMAS (PF02353)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0051220|Cyclopropane mycolic acid synthase 1 (cmaA1) ATGCCCGACGAGCTGAAGCCGCACTTCGCCAACGTGCAGGCGCACTACGACCTGTCCGAC GACTTCTTCCGGCTGTTCCTCGATCCCACTCAGACCTACAGCTGCGCCTACTTCGAGCGC GACGACATGACGCTGCAAGAGGCGCAGATCGCCAAGATCGATCTCGCGCTGGGCAAACTC GGATTGCAGCCGGGCATGACACTGTTGGACGTCGGCTGCGGCTGGGGCGCCACCATGATG CGCGCGGTGGAAAAATACGACGTCAACGTCGTCGGTCTGACCCTGAGCAAAAACCAGGCC AACCACGTTCAGCAGCTGGTCGCCAACTCCGAAAATCTACGCTCCAAACGCGTTCTGCTG GCCGGCTGGGAACAGTTTGACGAGCCCGTCGACCGCATCGTCAGCATCGGTGCTTTCGAA CATTTCGGTCACGAGCGCTACGACGCGTTCTTCAGCCTGGCGCATCGCCTGCTGCCCGCT GACGGGGTCATGCTGCTGCACACCATCACCGGGTTGCATCCGAAAGAGATCCACGAACGC GGCCTGCCCATGTCGTTCACCTTCGCTCGTTTCCTGAAATTCATTGTGACCGAGATCTTT CCGGGTGGGCGGCTGCCCTCGATACCGATGGTGCAGGAGTGTGCCAGCGCAAACGGCTTC ACCGTCACCAGAGTTCAATCGTTGCAGCCGCACTATGCGAAAACCCTCGACCTCTGGTCC GCGGCGTTGCAGGCCAACAAGGGCCAGGCCATCGCGCTGCAATCCGAGGAAGTCTACGAG CGGTATATGAAGTACCTCACCGGCTGCGCCGAGATGTTTCGCATCGGATACATCGACGTC AACCAGTTCACCTGCCAGAAGTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P9WPB7 UniProtKB Entry Name CMAS1_MYCTU - General References
- Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
- George KM, Yuan Y, Sherman DR, Barry CE 3rd: The biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis. Identification and functional analysis of CMAS-2. J Biol Chem. 1995 Nov 10;270(45):27292-8. [Article]
- Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]
- Huang CC, Smith CV, Glickman MS, Jacobs WR Jr, Sacchettini JC: Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis. J Biol Chem. 2002 Mar 29;277(13):11559-69. Epub 2001 Dec 26. [Article]