Cyclopropane mycolic acid synthase 1

Details

Name
Cyclopropane mycolic acid synthase 1
Synonyms
  • 2.1.1.79
  • AdoMet-MT
  • CFA synthase
  • cma1
  • CMAS
  • CMAS-1
  • Cyclopropane fatty acid synthase
  • Cyclopropane-fatty-acyl-phospholipid synthase
  • MA-MT
  • Mycolic acid methyltransferase
  • S-adenosylmethionine-dependent methyltransferase
  • SAM-MT
Gene Name
cmaA1
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Amino acid sequence
>lcl|BSEQ0051219|Cyclopropane mycolic acid synthase 1
MPDELKPHFANVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMTLQEAQIAKIDLALGKL
GLQPGMTLLDVGCGWGATMMRAVEKYDVNVVGLTLSKNQANHVQQLVANSENLRSKRVLL
AGWEQFDEPVDRIVSIGAFEHFGHERYDAFFSLAHRLLPADGVMLLHTITGLHPKEIHER
GLPMSFTFARFLKFIVTEIFPGGRLPSIPMVQECASANGFTVTRVQSLQPHYAKTLDLWS
AALQANKGQAIALQSEEVYERYMKYLTGCAEMFRIGYIDVNQFTCQK
Number of residues
287
Molecular Weight
32460.98
Theoretical pI
Not Available
GO Classification
Functions
cyclopropane-fatty-acyl-phospholipid synthase activity
Processes
lipid biosynthetic process / mycolic acid biosynthetic process / S-adenosylmethionine metabolic process
Components
cytoplasm / plasma membrane
General Function
Catalyzes the conversion of a double bond to a cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence.
Specific Function
Cyclopropane-fatty-acyl-phospholipid synthase activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0051220|Cyclopropane mycolic acid synthase 1 (cmaA1)
ATGCCCGACGAGCTGAAGCCGCACTTCGCCAACGTGCAGGCGCACTACGACCTGTCCGAC
GACTTCTTCCGGCTGTTCCTCGATCCCACTCAGACCTACAGCTGCGCCTACTTCGAGCGC
GACGACATGACGCTGCAAGAGGCGCAGATCGCCAAGATCGATCTCGCGCTGGGCAAACTC
GGATTGCAGCCGGGCATGACACTGTTGGACGTCGGCTGCGGCTGGGGCGCCACCATGATG
CGCGCGGTGGAAAAATACGACGTCAACGTCGTCGGTCTGACCCTGAGCAAAAACCAGGCC
AACCACGTTCAGCAGCTGGTCGCCAACTCCGAAAATCTACGCTCCAAACGCGTTCTGCTG
GCCGGCTGGGAACAGTTTGACGAGCCCGTCGACCGCATCGTCAGCATCGGTGCTTTCGAA
CATTTCGGTCACGAGCGCTACGACGCGTTCTTCAGCCTGGCGCATCGCCTGCTGCCCGCT
GACGGGGTCATGCTGCTGCACACCATCACCGGGTTGCATCCGAAAGAGATCCACGAACGC
GGCCTGCCCATGTCGTTCACCTTCGCTCGTTTCCTGAAATTCATTGTGACCGAGATCTTT
CCGGGTGGGCGGCTGCCCTCGATACCGATGGTGCAGGAGTGTGCCAGCGCAAACGGCTTC
ACCGTCACCAGAGTTCAATCGTTGCAGCCGCACTATGCGAAAACCCTCGACCTCTGGTCC
GCGGCGTTGCAGGCCAACAAGGGCCAGGCCATCGCGCTGCAATCCGAGGAAGTCTACGAG
CGGTATATGAAGTACCTCACCGGCTGCGCCGAGATGTTTCGCATCGGATACATCGACGTC
AACCAGTTCACCTGCCAGAAGTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP9WPB7
UniProtKB Entry NameCMAS1_MYCTU
General References
  1. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
  2. George KM, Yuan Y, Sherman DR, Barry CE 3rd: The biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis. Identification and functional analysis of CMAS-2. J Biol Chem. 1995 Nov 10;270(45):27292-8. [Article]
  3. Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]
  4. Huang CC, Smith CV, Glickman MS, Jacobs WR Jr, Sacchettini JC: Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis. J Biol Chem. 2002 Mar 29;277(13):11559-69. Epub 2001 Dec 26. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01718CetrimoniumapprovedunknownDetails