3-dehydroquinate dehydratase
Details
- Name
- 3-dehydroquinate dehydratase
- Synonyms
- 3-dehydroquinase
- 4.2.1.10
- aroD
- Type II DHQase
- Gene Name
- aroQ
- Organism
- Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
- Amino acid sequence
>lcl|BSEQ0051126|3-dehydroquinate dehydratase MSELIVNVINGPNLGRLGRREPAVYGGTTHDELVALIEREAAELGLKAVVRQSDSEAQLL DWIHQAADAAEPVILNAGGLTHTSVALRDACAELSAPLIEVHISNVHAREEFRRHSYLSP IATGVIVGLGIQGYLLALRYLAEHVGT
- Number of residues
- 147
- Molecular Weight
- 15789.81
- Theoretical pI
- Not Available
- GO Classification
- Functions3-dehydroquinate dehydratase activityProcessesaromatic amino acid family biosynthetic process / chorismate biosynthetic process / growthComponentscytosol
- General Function
- Catalyzes a trans-dehydration via an enolate intermediate.
- Specific Function
- 3-dehydroquinate dehydratase activity
- Pfam Domain Function
- DHquinase_II (PF01220)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0051127|3-dehydroquinate dehydratase (aroQ) ATGAGCGAACTGATCGTGAACGTGATCAACGGCCCCAACCTGGGCCGGTTGGGCCGGCGC GAGCCCGCCGTCTATGGCGGCACCACCCACGACGAGCTGGTCGCTCTGATCGAGCGTGAG GCCGCCGAGCTCGGACTCAAAGCCGTTGTGCGGCAAAGTGATAGCGAAGCCCAGCTGCTG GACTGGATTCATCAGGCCGCCGATGCGGCCGAACCCGTGATCCTCAACGCCGGCGGTCTG ACGCACACGTCGGTGGCACTGCGCGATGCCTGCGCGGAGCTGAGCGCTCCGCTGATCGAG GTGCATATCTCCAACGTGCATGCGCGTGAGGAGTTCCGCCGCCACTCCTACCTCAGCCCC ATCGCGACCGGGGTGATCGTCGGGCTCGGCATCCAGGGCTACCTGCTGGCCCTGCGGTAC CTAGCTGAGCATGTCGGGACGTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P9WPX7 UniProtKB Entry Name AROQ_MYCTU - General References
- Garbe T, Servos S, Hawkins A, Dimitriadis G, Young D, Dougan G, Charles I: The Mycobacterium tuberculosis shikimate pathway genes: evolutionary relationship between biosynthetic and catabolic 3-dehydroquinases. Mol Gen Genet. 1991 Sep;228(3):385-92. [Article]
- Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
- Raman K, Yeturu K, Chandra N: targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis. BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109. [Article]
- Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]
- Gourley DG, Shrive AK, Polikarpov I, Krell T, Coggins JR, Hawkins AR, Isaacs NW, Sawyer L: The two types of 3-dehydroquinase have distinct structures but catalyze the same overall reaction. Nat Struct Biol. 1999 Jun;6(6):521-5. [Article]
- Evans LD, Roszak AW, Noble LJ, Robinson DA, Chalk PA, Matthews JL, Coggins JR, Price NC, Lapthorn AJ: Specificity of substrate recognition by type II dehydroquinases as revealed by binding of polyanions. FEBS Lett. 2002 Oct 23;530(1-3):24-30. [Article]