Large neutral amino acids transporter small subunit 1
Details
- Name
- Large neutral amino acids transporter small subunit 1
- Synonyms
- 4F2 LC
- 4F2 light chain
- 4F2LC
- CD98 light chain
- CD98LC
- hLAT1
- Integral membrane protein E16
- L-type amino acid transporter 1
- LAT1
- MPE16
- Solute carrier family 7 member 5
- y+ system cationic amino acid transporter
- Gene Name
- SLC7A5
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010207|Large neutral amino acids transporter small subunit 1 MAGAGPKRRALAAPAAEEKEEAREKMLAAKSADGSAPAGEGEGVTLQRNITLLNGVAIIV GTIIGSGIFVTPTGVLKEAGSPGLALVVWAACGVFSIVGALCYAELGTTISKSGGDYAYM LEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPLFPTCPVPEEAAKLVACLCVL LLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFVQIGKGDVSNLDPNFSFEGTKLDV GNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTL STEQMLSSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLP SILSMIHPQLLTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLCVALAIIGMIWLRH RKPELERPIKVNLALPVFFILACLFLIAVSFWKTPVECGIGFTIILSGLPVYFFGVWWKN KPKWLLQGIFSTTVLCQKLMQVVPQET
- Number of residues
- 507
- Molecular Weight
- 55009.62
- Theoretical pI
- 7.79
- GO Classification
- Functionsamino acid transmembrane transporter activity / antiporter activity / L-leucine transmembrane transporter activity / L-phenylalanine transmembrane transporter activity / L-tryptophan transmembrane transporter activity / neutral amino acid transmembrane transporter activity / peptide antigen bindingProcessesamino acid transmembrane transport / amino acid transport / blood coagulation / cation transmembrane transport / cell differentiation / cellular amino acid metabolic process / ion transport / L-alpha-amino acid transmembrane transport / leucine transport / leukocyte migration / nervous system development / neutral amino acid transport / phenylalanine transport / transmembrane transport / transport / tryptophan transportComponentsapical plasma membrane / cytoplasm / cytosol / extracellular exosome / integral component of plasma membrane / intracellular membrane-bounded organelle / membrane / plasma membrane
- General Function
- Peptide antigen binding
- Specific Function
- Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L-leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts.
- Pfam Domain Function
- AA_permease_2 (PF13520)
- Transmembrane Regions
- 50-70 84-104 120-140 146-166 170-190 199-219 243-263 274-294 319-339 396-416 431-451 458-478
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0010208|Large neutral amino acids transporter small subunit 1 (SLC7A5) ATGGCGGGTGCGGGCCCGAAGCGGCGCGCGCTAGCGGCGCCGGCGGCCGAGGAGAAGGAA GAGGCGCGGGAGAAGATGCTGGCCGCCAAGAGCGCGGACGGCTCGGCGCCGGCAGGCGAG GGCGAGGGCGTGACCCTGCAGCGGAACATCACGCTGCTCAACGGCGTGGCCATCATCGTG GGGACCATTATCGGCTCGGGCATCTTCGTGACGCCCACGGGCGTGCTCAAGGAGGCAGGC TCGCCGGGGCTGGCGCTGGTGGTGTGGGCCGCGTGCGGCGTCTTCTCCATCGTGGGCGCG CTCTGCTACGCGGAGCTCGGCACCACCATCTCCAAATCGGGCGGCGACTACGCCTACATG CTGGAGGTCTACGGCTCGCTGCCCGCCTTCCTCAAGCTCTGGATCGAGCTGCTCATCATC CGGCCTTCATCGCAGTACATCGTGGCCCTGGTCTTCGCCACCTACCTGCTCAAGCCGCTC TTCCCCACCTGCCCGGTGCCCGAGGAGGCAGCCAAGCTCGTGGCCTGCCTCTGCGTGCTG CTGCTCACGGCCGTGAACTGCTACAGCGTGAAGGCCGCCACCCGGGTCCAGGATGCCTTT GCCGCCGCCAAGCTCCTGGCCCTGGCCCTGATCATCCTGCTGGGCTTCGTCCAGATCGGG AAGGGTGATGTGTCCAATCTAGATCCCAACTTCTCATTTGAAGGCACCAAACTGGATGTG GGGAACATTGTGCTGGCATTATACAGCGGCCTCTTTGCCTATGGAGGATGGAATTACTTG AATTTCGTCACAGAGGAAATGATCAACCCCTACAGAAACCTGCCCCTGGCCATCATCATC TCCCTGCCCATCGTGACGCTGGTGTACGTGCTGACCAACCTGGCCTACTTCACCACCCTG TCCACCGAGCAGATGCTGTCGTCCGAGGCCGTGGCCGTGGACTTCGGGAACTATCACCTG GGCGTCATGTCCTGGATCATCCCCGTCTTCGTGGGCCTGTCCTGCTTCGGCTCCGTCAAT GGGTCCCTGTTCACATCCTCCAGGCTCTTCTTCGTGGGGTCCCGGGAAGGCCACCTGCCC TCCATCCTCTCCATGATCCACCCACAGCTCCTCACCCCCGTGCCGTCCCTCGTGTTCACG TGTGTGATGACGCTGCTCTACGCCTTCTCCAAGGACATCTTCTCCGTCATCAACTTCTTC AGCTTCTTCAACTGGCTCTGCGTGGCCCTGGCCATCATCGGCATGATCTGGCTGCGCCAC AGAAAGCCTGAGCTTGAGCGGCCCATCAAGGTGAACCTGGCCCTGCCTGTGTTCTTCATC CTGGCCTGCCTCTTCCTGATCGCCGTCTCCTTCTGGAAGACACCCGTGGAGTGTGGCATC GGCTTCACCATCATCCTCAGCGGGCTGCCCGTCTACTTCTTCGGGGTCTGGTGGAAAAAC AAGCCCAAGTGGCTCCTCCAGGGCATCTTCTCCACGACCGTCCTGTGTCAGAAGCTCATG CAGGTGGTCCCCCAGGAGACATAG
- Chromosome Location
- 16
- Locus
- 16q24.3
- External Identifiers
Resource Link UniProtKB ID Q01650 UniProtKB Entry Name LAT1_HUMAN GenBank Protein ID 3639058 GenBank Gene ID AF077866 GenAtlas ID SLC7A5 HGNC ID HGNC:11063 - General References
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- Broer A, Friedrich B, Wagner CA, Fillon S, Ganapathy V, Lang F, Broer S: Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains. Biochem J. 2001 May 1;355(Pt 3):725-31. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB02750 S-(Methylmercury)-L-Cysteine experimental unknown Details DB01235 Levodopa approved unknown Details DB00279 Liothyronine approved, vet_approved unknown Details DB00451 Levothyroxine approved unknown Details DB00509 Dextrothyroxine approved, investigational unknown Details DB01042 Melphalan approved unknown substrate Details DB01746 D-Leucine experimental unknown Details DB02556 D-Phenylalanine experimental unknown Details DB00230 Pregabalin approved, investigational no substrate Details DB00996 Gabapentin approved, investigational unknown substrate Details DB09100 Thyroid, porcine approved unknown substrate Details DB00130 L-Glutamine approved, investigational, nutraceutical unknown substrate Details