Semenogelin-2
Details
- Name
- Semenogelin-2
- Synonyms
- Semenogelin II
- SGII
- Gene Name
- SEMG2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052389|Semenogelin-2 MKSIILFVLSLLLILEKQAAVMGQKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSK GSFSIQHTYHVDINDHDWTRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSK GHFHMIVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASG AQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHP AHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHH GEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNC GEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNS GEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNY GGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQDLLSH EQKGRYKQESSESHNIVITEHEVAQDDHLTQQYNEDRNPIST
- Number of residues
- 582
- Molecular Weight
- 65444.485
- Theoretical pI
- Not Available
- GO Classification
- Functionsprotease binding / zinc ion bindingProcessesantibacterial humoral response / coagulation / negative regulation of flagellated sperm motility / positive regulation of serine-type endopeptidase activity / sperm capacitationComponentsextracellular exosome / extracellular space / nucleus
- General Function
- Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.
- Specific Function
- Protease binding
- Pfam Domain Function
- Semenogelin (PF05474)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0052390|Semenogelin-2 (SEMG2) ATGAAGTCCATCATCCTCTTTGTCCTTTCCCTGCTCCTTATCTTGGAGAAGCAAGCAGCT GTGATGGGACAAAAAGGTGGATCAAAAGGCCAATTGCCAAGCGGATCTTCCCAATTTCCA CATGGACAAAAGGGCCAGCACTATTTTGGACAAAAAGACCAACAACATACTAAATCCAAA GGCAGTTTTTCTATTCAACACACATATCATGTAGACATCAATGATCATGACTGGACCCGA AAAAGTCAGCAATATGATTTGAATGCCCTACATAAGGCGACAAAATCAAAACAACACCTA GGTGGAAGTCAACAACTGCTCAATTATAAACAAGAAGGCAGAGACCATGATAAATCAAAA GGTCATTTTCACATGATAGTTATACATCATAAAGGAGGCCAAGCTCATCATGGGACACAA AATCCTTCTCAAGATCAGGGGAATAGCCCATCTGGAAAGGGATTATCCAGTCAATGTTCA AACACAGAAAAAAGGCTATGGGTTCATGGACTAAGTAAAGAACAAGCTTCAGCCTCTGGT GCACAAAAAGGTAGAACACAAGGTGGATCCCAAAGCAGTTATGTTCTCCAAACTGAAGAA CTAGTAGTTAACAAACAACAACGTGAGACTAAAAATTCTCATCAAAATAAAGGGCATTAC CAAAATGTGGTTGACGTGAGAGAGGAACATTCAAGTAAACTACAAACTTCACTCCATCCT GCACATCAAGACAGACTCCAACATGGACCCAAAGACATTTTTACTACCCAAGATGAGCTC CTAGTATATAACAAGAATCAACACCAGACAAAAAATCTCAGTCAAGATCAAGAGCATGGC CGGAAGGCACATAAAATATCATACCCGTCTTCACGTACAGAAGAAAGACAACTTCACCAT GGAGAAAAGAGTGTACAGAAAGATGTATCCAAAGGCAGCATTTCTATCCAAACTGAAGAG AAAATACATGGCAAGTCTCAAAACCAGGTAACAATTCATAGTCAAGATCAAGAGCATGGC CATAAGGAAAATAAAATATCATACCAATCTTCAAGTACAGAAGAAAGACATCTCAACTGT GGAGAAAAGGGCATCCAGAAAGGTGTATCCAAAGGCAGTATTTCGATCCAAACTGAAGAG CAAATACATGGCAAGTCTCAAAACCAGGTAAGAATTCCTAGTCAAGCTCAAGAGTATGGC CATAAGGAAAATAAAATATCATACCAATCTTCGAGTACAGAAGAAAGACGTCTCAACAGT GGAGAAAAGGATGTACAGAAAGGTGTATCCAAAGGCAGTATTTCTATCCAAACTGAAGAG AAAATACATGGCAAGTCTCAAAACCAGGTAACAATTCCTAGTCAAGATCAAGAGCATGGC CATAAGGAAAATAAAATGTCATACCAATCTTCAAGTACAGAAGAAAGACGACTCAACTAT GGAGGAAAGAGCACGCAGAAAGATGTATCCCAAAGCAGTATTTCTTTCCAAATTGAAAAG CTAGTAGAAGGCAAGTCTCAAATCCAGACACCAAATCCTAATCAAGATCAATGGTCTGGC CAAAATGCAAAAGGAAAGTCTGGTCAATCTGCAGATAGCAAACAAGACCTACTCAGTCAT GAACAAAAAGGCAGATACAAACAGGAATCCAGTGAGTCACATAATATTGTAATTACTGAG CATGAGGTTGCCCAAGATGATCATTTGACACAACAATATAATGAAGACAGAAATCCAATA TCTACATAG
- Chromosome Location
- 20
- Locus
- 20q13.12
- External Identifiers
Resource Link UniProtKB ID Q02383 UniProtKB Entry Name SEMG2_HUMAN HGNC ID HGNC:10743 - General References
- Lilja H, Lundwall A: Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related protein. Proc Natl Acad Sci U S A. 1992 May 15;89(10):4559-63. doi: 10.1073/pnas.89.10.4559. [Article]
- Ulvsback M, Lazure C, Lilja H, Spurr NK, Rao VV, Loffler C, Hansmann I, Lundwall A: Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20. J Biol Chem. 1992 Sep 5;267(25):18080-4. [Article]
- Jensen-Seaman MI, Li WH: Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen. J Mol Evol. 2003 Sep;57(3):261-70. [Article]
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- Schneider K, Kausler W, Tripier D, Jouvenal K, Spiteller G: [Isolation and structure determination of two peptides occurring in human seminal plasma]. Biol Chem Hoppe Seyler. 1989 Apr;370(4):353-6. [Article]
- Malm J, Hellman J, Magnusson H, Laurell CB, Lilja H: Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II. Eur J Biochem. 1996 May 15;238(1):48-53. doi: 10.1111/j.1432-1033.1996.0048q.x. [Article]
- Kise H, Nishioka J, Kawamura J, Suzuki K: Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor. Eur J Biochem. 1996 May 15;238(1):88-96. [Article]