Sialidase
Details
- Name
- Sialidase
- Synonyms
- 3.2.1.18
- Neuraminidase
- Gene Name
- nedA
- Organism
- Micromonospora viridifaciens
- Amino acid sequence
>lcl|BSEQ0016618|Sialidase MTANPYLRRLPRRRAVSFLLAPALAAATVAGASPAQAIAGAPVPPGGEPLYTEQDLAVNG REGFPNYRIPALTVTPDGDLLASYDGRPTGIDAPGPNSILQRRSTDGGRTWGEQQVVSAG QTTAPIKGFSDPSYLVDRETGTIFNFHVYSQRQGFAGSRPGTDPADPNVLHANVATSTDG GLTWSHRTITADITPDPGWRSRFAASGEGIQLRYGPHAGRLIQQYTIINAAGAFQAVSVY SDDHGRTWRAGEAVGVGMDENKTVELSDGRVLLNSRDSARSGYRKVAVSTDGGHSYGPVT IDRDLPDPTNNASIIRAFPDAPAGSARAKVLLFSNAASQTSRSQGTIRMSCDDGQTWPVS KVFQPGSMSYSTLTALPDGTYGLLYEPGTGIRYANFNLAWLGGICAPFTIPDVALEPGQQ VTVPVAVTNQSGIAVPKPSLQLDASPDWQVQGSVEPLMPGRQAKGQVTITVPAGTTPGRY RVGATLRTSAGNASTTFTVTVGLLDQARMSIADVDSEETAREDGRASNVIDGNPSTFWHT EWSRADAPGYPHRISLDLGGTHTISGLQYTRRQNSANEQVADYEIYTSLNGTTWDGPVAS GRFTTSLAPQRAVFPARDARYIRLVALSEQTGHKYAAVAELEVEGQR
- Number of residues
- 647
- Molecular Weight
- 68829.78
- Theoretical pI
- 6.52
- GO Classification
- Functionsexo-alpha-(2->3)-sialidase activity / exo-alpha-(2->6)-sialidase activity / exo-alpha-(2->8)-sialidase activityComponentsextracellular region
- General Function
- Exo-alpha-(2->8)-sialidase activity
- Specific Function
- To release sialic acids for use as carbon and energy sources for this non-pathogenic bacterium while in pathogenic microorganisms, sialidases have been suggested to be pathogenic factors.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0003854|1944 bp ATGACTGCGAATCCGTACCTCCGCCGCCTGCCCCGGCGCCGAGCCGTCAGCTTCCTGCTC GCACCAGCGCTGGCGGCCGCCACGGTCGCCGGCGCGTCCCCCGCACAGGCCATCGCCGGG GCACCCGTCCCGCCCGGCGGCGAGCCGCTCTACACGGAGCAGGACCTCGCCGTGAACGGC AGGGAGGGCTTTCCGAACTACCGCATCCCAGCGCTGACCGTCACGCCCGACGGGGACCTG CTGGCCTCGTACGACGGCCGCCCGACCGGTATCGACGCGCCCGGCCCCAACTCCATCCTC CAACGCCGCAGCACCGACGGCGGCCGGACGTGGGGCGAGCAACAGGTCGTCAGCGCCGGC CAGACCACCGCGCCGATCAAGGGGTTCTCCGACCCCAGCTACCTTGTCGACCGGGAAACC GGGACCATCTTCAACTTCCACGTCTACTCCCAGCGGCAGGGCTTCGCCGGCAGCCGGCCC GGCACCGACCCGGCAGACCCCAACGTGCTCCACGCCAACGTCGCGACCTCGACCGACGGC GGTCTGACCTGGTCGCACCGGACCATCACGGCCGACATCACCCCGGATCCGGGCTGGCGC AGCCGCTTCGCCGCCTCCGGCGAAGGCATCCAGCTCCGCTATGGACCCCACGCCGGTCGA CTCATCCAGCAGTACACGATCATCAACGCTGCCGGCGCCTTCCAGGCGGTGAGCGTGTAC AGCGACGACCACGGAAGGACCTGGCGCGCCGGCGAAGCCGTCGGGGTCGGCATGGACGAG AACAAGACCGTGGAACTCTCCGATGGCCGGGTCCTGCTCAACAGCCGCGACTCGGCCCGC AGCGGATACCGTAAGGTGGCCGTCTCCACTGACGGCGGCCACAGCTACGGCCCGGTGACC ATCGACCGCGACCTCCCCGACCCGACGAACAACGCATCGATCATCCGGGCCTTCCCTGAC GCCCCGGCCGGCTCCGCGCGGGCCAAGGTCCTGCTCTTCTCCAACGCCGCCAGCCAGACC TCGCGCAGTCAGGGCACCATCCGGATGTCCTGCGACGATGGCCAGACCTGGCCGGTTTCG AAGGTCTTCCAGCCCGGCTCGATGTCGTACTCCACCCTGACCGCACTGCCCGACGGCACC TACGGGCTGCTGTACGAGCCGGGCACCGGCATCAGATACGCCAACTTCAACCTCGCCTGG CTGGGCGGCATCTGCGCGCCCTTCACGATTCCGGATGTGGCGCTCGAGCCGGGCCAGCAG GTCACTGTTCCGGTGGCCGTCACGAACCAGTCCGGTATCGCGGTACCGAAGCCGAGCCTT CAGCTCGACGCATCGCCGGACTGGCAGGTTCAGGGTTCCGTCGAGCCCCTCATGCCCGGA CGGCAGGCCAAGGGCCAGGTGACCATCACGGTTCCCGCCGGCACCACCCCCGGTCGCTAC CGGGTCGGTGCGACGCTGCGCACCTCCGCGGGTAACGCGTCGACGACCTTCACGGTCACG GTTGGACTGCTCGACCAGGCCCGGATGAGCATCGCGGACGTCGACAGCGAGGAGACCGCC CGCGAAGACGGGCGGGCGAGCAACGTGATCGACGGCAACCCCTCGACGTTCTGGCACACC GAATGGTCGCGTGCCGATGCTCCTGGCTACCCGCACCGCATCAGCCTCGACCTCGGTGGC ACGCACACGATCAGCGGCCTCCAGTACACCCGACGGCAGAACAGCGCCAACGAGCAGGTC GCGGACTACGAGATCTACACCAGCCTGAACGGCACGACCTGGGATGGCCCGGTTGCCAGC GGGCGCTTCACCACGTCCCTCGCGCCGCAGCGCGCGGTCTTCCCGGCGCGGGACGCCAGG TACATCCGGTTGGTGGCCCTCAGCGAGCAGACCGGGCACAAGTACGCCGCGGTCGCTGAG CTGGAGGTGGAAGGCCAGCGCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q02834 UniProtKB Entry Name NANH_MICVI GenBank Protein ID 216784 GenBank Gene ID D01045 - General References
- Sakurada K, Ohta T, Hasegawa M: Cloning, expression, and characterization of the Micromonospora viridifaciens neuraminidase gene in Streptomyces lividans. J Bacteriol. 1992 Nov;174(21):6896-903. [Article]
- Gaskell A, Crennell S, Taylor G: The three domains of a bacterial sialidase: a beta-propeller, an immunoglobulin module and a galactose-binding jelly-roll. Structure. 1995 Nov 15;3(11):1197-205. [Article]