Peroxisome proliferator-activated receptor delta

Details

Name
Peroxisome proliferator-activated receptor delta
Synonyms
  • NR1C2
  • NUC1
  • NUCI
  • Nuclear hormone receptor 1
  • Nuclear receptor subfamily 1 group C member 2
  • Peroxisome proliferator-activated receptor beta
  • PPAR-beta
  • PPAR-delta
  • PPARB
Gene Name
PPARD
Organism
Humans
Amino acid sequence
>lcl|BSEQ0002005|Peroxisome proliferator-activated receptor delta
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQM
GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKK
NRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSK
HIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKE
ISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNK
DGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGD
RPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRI
KKTETETSLHPLLQEIYKDMY
Number of residues
441
Molecular Weight
49902.99
Theoretical pI
7.65
GO Classification
Functions
DNA binding / drug binding / linoleic acid binding / lipid binding / RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding / sequence-specific DNA binding / steroid hormone receptor activity / transcription factor activity, sequence-specific DNA binding / zinc ion binding
Processes
adipose tissue development / apoptotic process / apoptotic signaling pathway / axon ensheathment / cell differentiation / cell proliferation / cell-substrate adhesion / cellular response to hypoxia / cholesterol metabolic process / decidualization / embryo implantation / fatty acid beta-oxidation / fatty acid catabolic process / fatty acid transport / gene expression / generation of precursor metabolites and energy / glucose metabolic process / glucose transport / intracellular receptor signaling pathway / keratinocyte migration / keratinocyte proliferation / lipid metabolic process / negative regulation of epithelial cell proliferation / negative regulation of myoblast differentiation / negative regulation of transcription from RNA polymerase II promoter / negative regulation of transcription, DNA-templated / positive regulation of fat cell differentiation / positive regulation of myoblast proliferation / positive regulation of phosphatidylinositol 3-kinase signaling / positive regulation of skeletal muscle tissue regeneration / positive regulation of transcription, DNA-templated / regulation of satellite cell proliferation / regulation of transcription from RNA polymerase II promoter / transcription initiation from RNA polymerase II promoter / wound healing
Components
nucleoplasm / nucleus
General Function
Zinc ion binding
Specific Function
Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0019047|Peroxisome proliferator-activated receptor delta (PPARD)
ATGGAGCAGCCACAGGAGGAAGCCCCTGAGGTCCGGGAAGAGGAGGAGAAAGAGGAAGTG
GCAGAGGCAGAAGGAGCCCCAGAGCTCAATGGGGGACCACAGCATGCACTTCCTTCCAGC
AGCTACACAGACCTCTCCCGGAGCTCCTCGCCACCCTCACTGCTGGACCAACTGCAGATG
GGCTGTGACGGGGCCTCATGCGGCAGCCTCAACATGGAGTGCCGGGTGTGCGGGGACAAG
GCATCGGGCTTCCACTACGGTGTTCATGCATGTGAGGGGTGCAAGGGCTTCTTCCGTCGT
ACGATCCGCATGAAGCTGGAGTACGAGAAGTGTGAGCGCAGCTGCAAGATTCAGAAGAAG
AACCGCAACAAGTGCCAGTACTGCCGCTTCCAGAAGTGCCTGGCACTGGGCATGTCACAC
AACGCTATCCGTTTTGGTCGGATGCCGGAGGCTGAGAAGAGGAAGCTGGTGGCAGGGCTG
ACTGCAAACGAGGGGAGCCAGTACAACCCACAGGTGGCCGACCTGAAGGCCTTCTCCAAG
CACATCTACAATGCCTACCTGAAAAACTTCAACATGACCAAAAAGAAGGCCCGCAGCATC
CTCACCGGCAAAGCCAGCCACACGGCGCCCTTTGTGATCCACGACATCGAGACATTGTGG
CAGGCAGAGAAGGGGCTGGTGTGGAAGCAGTTGGTGAATGGCCTGCCTCCCTACAAGGAG
ATCAGCGTGCACGTCTTCTACCGCTGCCAGTGCACCACAGTGGAGACCGTGCGGGAGCTC
ACTGAGTTCGCCAAGAGCATCCCCAGCTTCAGCAGCCTCTTCCTCAACGACCAGGTTACC
CTTCTCAAGTATGGCGTGCACGAGGCCATCTTCGCCATGCTGGCCTCTATCGTCAACAAG
GACGGGCTGCTGGTAGCCAACGGCAGTGGCTTTGTCACCCGTGAGTTCCTGCGCAGCCTC
CGCAAACCCTTCAGTGATATCATTGAGCCTAAGTTTGAATTTGCTGTCAAGTTCAACGCC
CTGGAACTTGATGACAGTGACCTGGCCCTATTCATTGCGGCCATCATTCTGTGTGGAGAC
CGGCCAGGCCTCATGAACGTTCCACGGGTGGAGGCTATCCAGGACACCATCCTGCGTGCC
CTCGAATTCCACCTGCAGGCCAACCACCCTGATGCCCAGTACCTCTTCCCCAAGCTGCTG
CAGAAGATGGCTGACCTGCGGCAACTGGTCACCGAGCACGCCCAGATGATGCAGCGGATC
AAGAAGACCGAAACCGAGACCTCGCTGCACCCTCTGCTCCAGGAGATCTACAAGGACATG
TACTAA
Chromosome Location
6
Locus
6p21.2-p21.1
External Identifiers
ResourceLink
UniProtKB IDQ03181
UniProtKB Entry NamePPARD_HUMAN
GenBank Protein ID190230
GenBank Gene IDL07592
GenAtlas IDPPARD
HGNC IDHGNC:9235
General References
  1. Schmidt A, Endo N, Rutledge SJ, Vogel R, Shinar D, Rodan GA: Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Mol Endocrinol. 1992 Oct;6(10):1634-41. [PubMed:1333051]
  2. Skogsberg J, Kannisto K, Roshani L, Gagne E, Hamsten A, Larsson C, Ehrenborg E: Characterization of the human peroxisome proliferator activated receptor delta gene and its expression. Int J Mol Med. 2000 Jul;6(1):73-81. [PubMed:10851270]
  3. Kobayashi T, Kodani Y, Nozawa A, Endo Y, Sawasaki T: DNA-binding profiling of human hormone nuclear receptors via fluorescence correlation spectroscopy in a cell-free system. FEBS Lett. 2008 Aug 6;582(18):2737-44. doi: 10.1016/j.febslet.2008.07.003. Epub 2008 Jul 11. [PubMed:18619963]
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  8. Xu HE, Lambert MH, Montana VG, Parks DJ, Blanchard SG, Brown PJ, Sternbach DD, Lehmann JM, Wisely GB, Willson TM, Kliewer SA, Milburn MV: Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. Mol Cell. 1999 Mar;3(3):397-403. [PubMed:10198642]
  9. Takada I, Yu RT, Xu HE, Lambert MH, Montana VG, Kliewer SA, Evans RM, Umesono K: Alteration of a single amino acid in peroxisome proliferator-activated receptor-alpha (PPAR alpha) generates a PPAR delta phenotype. Mol Endocrinol. 2000 May;14(5):733-40. [PubMed:10809235]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00374Treprostinilapproved, investigationalyesagonistDetails
DB00605Sulindacapproved, investigationalunknownnegative modulatorDetails
DB03338Heptyl glucosideexperimentalunknownDetails
DB00159Icosapentapproved, nutraceuticalyesagonistDetails
DB04801cis-Vaccenic acidexperimentalunknownDetails
DB05188KD3010investigationalunknownDetails
DB05187ElafibranorinvestigationalunknownDetails
DB01393Bezafibrateapproved, investigationalyesagonistDetails
DB07070(2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acidexperimentalunknownDetails
DB076912-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acidexperimentalunknownDetails
DB07724IndeglitazarexperimentalunknownDetails
DB08078{4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy}acetic acidexperimentalunknownDetails
DB09462Glycerinapproved, investigationalyesagonistDetails
DB09006ClinofibrateexperimentalunknownDetails
DB00412Rosiglitazoneapproved, investigationalunknownDetails
DB00197Troglitazoneapproved, investigational, withdrawnunknownDetails
DB00132alpha-Linolenic acidapproved, investigational, nutraceuticalunknownDetails
DB04224Oleic Acidapproved, investigational, vet_approvedunknownDetails
DB05416CardarineinvestigationalunknownagonistDetails
DB02746Phthalic AcidexperimentalunknownDetails
DB00313Valproic acidapproved, investigationalunknownDetails
DB13873Fenofibric acidapprovedunknownunknownDetails
DB13961Fish oilapproved, nutraceuticalunknownregulatorDetails