Urokinase plasminogen activator surface receptor

Details

Name
Urokinase plasminogen activator surface receptor
Synonyms
  • MO3
  • Monocyte activation antigen Mo3
  • U-PAR
  • UPAR
Gene Name
PLAUR
Organism
Humans
Amino acid sequence
>lcl|BSEQ0001430|Urokinase plasminogen activator surface receptor
MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEEL
ELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISC
GSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNG
FHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGP
MNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDV
QYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT
Number of residues
335
Molecular Weight
36977.62
Theoretical pI
6.64
GO Classification
Functions
enzyme binding / protein domain specific binding / receptor activity / receptor binding / urokinase plasminogen activator receptor activity
Processes
attachment of GPI anchor to protein / blood coagulation / C-terminal protein lipidation / cellular protein metabolic process / chemotaxis / fibrinolysis / movement of cell or subcellular component / negative regulation of apoptotic process / negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway / negative regulation of intrinsic apoptotic signaling pathway / positive regulation of DNA binding / positive regulation of epidermal growth factor receptor signaling pathway / positive regulation of protein phosphorylation / positive regulation of release of cytochrome c from mitochondria / post-translational protein modification / regulation of proteolysis / signal transduction / urokinase plasminogen activator signaling pathway
Components
anchored component of membrane / endoplasmic reticulum lumen / endoplasmic reticulum membrane / extracellular exosome / extrinsic component of membrane / focal adhesion / integral component of membrane / integral component of plasma membrane / invadopodium membrane / plasma membrane
General Function
Urokinase plasminogen activator receptor activity
Specific Function
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0016188|Urokinase plasminogen activator surface receptor (PLAUR)
ATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCCACACCTGCGTCCCAGCCTCT
TGGGGCCTGCGGTGCATGCAGTGTAAGACCAACGGGGATTGCCGTGTGGAAGAGTGCGCC
CTGGGACAGGACCTCTGCAGGACCACGATCGTGCGCTTGTGGGAAGAAGGAGAAGAGCTG
GAGCTGGTGGAGAAAAGCTGTACCCACTCAGAGAAGACCAACAGGACCCTGAGCTATCGG
ACTGGCTTGAAGATCACCAGCCTTACCGAGGTTGTGTGTGGGTTAGACTTGTGCAACCAG
GGCAACTCTGGCCGGGCTGTCACCTATTCCCGAAGCCGTTACCTCGAATGCATTTCCTGT
GGCTCATCAGACATGAGCTGTGAGAGGGGCCGGCACCAGAGCCTGCAGTGCCGCAGCCCT
GAAGAACAGTGCCTGGATGTGGTGACCCACTGGATCCAGGAAGGTGAAGAAGGGCGTCCA
AAGGATGACCGCCACCTCCGTGGCTGTGGCTACCTTCCCGGCTGCCCGGGCTCCAATGGT
TTCCACAACAACGACACCTTCCACTTCCTGAAATGCTGCAACACCACCAAATGCAACGAG
GGCCCAATCCTGGAGCTTGAAAATCTGCCGCAGAATGGCCGCCAGTGTTACAGCTGCAAG
GGGAACAGCACCCATGGATGCTCCTCTGAAGAGACTTTCCTCATTGACTGCCGAGGCCCC
ATGAATCAATGTCTGGTAGCCACCGGCACTCACGAACGCTCACTCTGGGGAAGCTGGTTG
CCATGTAAAAGTACTACTGCCCTGAGACCACCATGCTGTGAGGAAGCCCAAGCTACTCAT
GTATAA
Chromosome Location
19
Locus
19q13
External Identifiers
ResourceLink
UniProtKB IDQ03405
UniProtKB Entry NameUPAR_HUMAN
GenBank Protein ID37605
GenBank Gene IDX51675
GenAtlas IDPLAUR
HGNC IDHGNC:9053
General References
  1. Roldan AL, Cubellis MV, Masucci MT, Behrendt N, Lund LR, Dano K, Appella E, Blasi F: Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis. EMBO J. 1990 Feb;9(2):467-74. [Article]
  2. Min HY, Semnani R, Mizukami IF, Watt K, Todd RF 3rd, Liu DY: cDNA for Mo3, a monocyte activation antigen, encodes the human receptor for urokinase plasminogen activator. J Immunol. 1992 Jun 1;148(11):3636-42. [Article]
  3. Bayraktutan U, Jones P: A novel urokinase receptor on monocyte-like macrophage cell line. Biochem Soc Trans. 1993 Nov;21(4):395S. [Article]
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  5. Casey JR, Petranka JG, Kottra J, Fleenor DE, Rosse WF: The structure of the urokinase-type plasminogen activator receptor gene. Blood. 1994 Aug 15;84(4):1151-6. [Article]
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  17. Elortza F, Nuhse TS, Foster LJ, Stensballe A, Peck SC, Jensen ON: Proteomic analysis of glycosylphosphatidylinositol-anchored membrane proteins. Mol Cell Proteomics. 2003 Dec;2(12):1261-70. Epub 2003 Sep 29. [Article]
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  21. Llinas P, Le Du MH, Gardsvoll H, Dano K, Ploug M, Gilquin B, Stura EA, Menez A: Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide. EMBO J. 2005 May 4;24(9):1655-63. Epub 2005 Apr 7. [Article]
  22. Huai Q, Mazar AP, Kuo A, Parry GC, Shaw DE, Callahan J, Li Y, Yuan C, Bian C, Chen L, Furie B, Furie BC, Cines DB, Huang M: Structure of human urokinase plasminogen activator in complex with its receptor. Science. 2006 Feb 3;311(5761):656-9. [Article]
  23. Xu X, Gardsvoll H, Yuan C, Lin L, Ploug M, Huang M: Crystal structure of the urokinase receptor in a ligand-free form. J Mol Biol. 2012 Mar 9;416(5):629-41. doi: 10.1016/j.jmb.2011.12.058. Epub 2012 Jan 21. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00013Urokinaseapproved, investigational, withdrawnyesinducermodulatorDetails
DB00031TenecteplaseapprovedunknownDetails
DB05476WX-UK1investigationalunknownDetails
DB06245LanoteplaseinvestigationalunknownDetails