Transcription factor p65

Details

Name
Transcription factor p65
Synonyms
  • NFKB3
  • Nuclear factor NF-kappa-B p65 subunit
  • Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
Gene Name
RELA
Organism
Humans
Amino acid sequence
>lcl|BSEQ0009299|Transcription factor p65
MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPT
IKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQC
VKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLS
HPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFS
QADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEE
KRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINY
DEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQA
VAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQ
GIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADM
DFSALLSQISS
Number of residues
551
Molecular Weight
60218.53
Theoretical pI
Not Available
GO Classification
Functions
actinin binding / activating transcription factor binding / chromatin binding / chromatin DNA binding / DNA binding / histone deacetylase binding / identical protein binding / NF-kappaB binding / phosphate ion binding / protein heterodimerization activity / protein homodimerization activity / protein kinase binding / protein N-terminus binding / repressing transcription factor binding / RNA polymerase II core promoter proximal region sequence-specific DNA binding / RNA polymerase II distal enhancer sequence-specific DNA binding / RNA polymerase II regulatory region sequence-specific DNA binding / transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding / transcription factor activity, sequence-specific DNA binding / transcription factor binding / transcription regulatory region DNA binding / transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding / transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding / transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding / ubiquitin protein ligase binding
Processes
acetaldehyde metabolic process / aging / cellular defense response / cellular response to hydrogen peroxide / cellular response to interleukin-1 / cellular response to interleukin-6 / cellular response to lipopolysaccharide / cellular response to nicotine / cellular response to peptide hormone stimulus / cellular response to tumor necrosis factor / cytokine-mediated signaling pathway / defense response to virus / Fc-epsilon receptor signaling pathway / hair follicle development / I-kappaB kinase/NF-kappaB signaling / inflammatory response / innate immune response / liver development / membrane protein intracellular domain proteolysis / MyD88-dependent toll-like receptor signaling pathway / MyD88-independent toll-like receptor signaling pathway / negative regulation of apoptotic process / negative regulation of extrinsic apoptotic signaling pathway / negative regulation of insulin receptor signaling pathway / negative regulation of NIK/NF-kappaB signaling / negative regulation of protein catabolic process / negative regulation of transcription from RNA polymerase II promoter / negative regulation of transcription, DNA-templated / neurotrophin TRK receptor signaling pathway / NIK/NF-kappaB signaling / nucleotide-binding oligomerization domain containing 2 signaling pathway / organ morphogenesis / positive regulation of cell proliferation / positive regulation of chondrocyte differentiation / positive regulation of I-kappaB kinase/NF-kappaB signaling / positive regulation of interleukin-12 biosynthetic process / positive regulation of miRNA metabolic process / positive regulation of NF-kappaB transcription factor activity / positive regulation of Schwann cell differentiation / positive regulation of transcription from RNA polymerase II promoter / positive regulation of transcription, DNA-templated / positive regulation of type I interferon production / regulation of inflammatory response / response to amino acid / response to cAMP / response to cobalamin / response to drug / response to insulin / response to interleukin-1 / response to morphine / response to muramyl dipeptide / response to muscle stretch / response to organic substance / response to progesterone / response to UV-B / stimulatory C-type lectin receptor signaling pathway / T cell receptor signaling pathway / toll-like receptor 10 signaling pathway / toll-like receptor 2 signaling pathway / toll-like receptor 3 signaling pathway / toll-like receptor 4 signaling pathway / toll-like receptor 5 signaling pathway / toll-like receptor 9 signaling pathway / toll-like receptor signaling pathway / toll-like receptor TLR1 / toll-like receptor TLR6 / transcription from RNA polymerase II promoter / TRIF-dependent toll-like receptor signaling pathway / viral process
Components
cytoplasm / cytosol / I-kappaB/NF-kappaB complex / NF-kappaB complex / nucleoplasm / nucleus / transcription factor complex
General Function
Ubiquitin protein ligase binding
Specific Function
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0013727|Transcription factor p65 (RELA)
ATGGACGAACTGTTCCCCCTCATCTTCCCGGCAGAGCCAGCCCAGGCCTCTGGCCCCTAT
GTGGAGATCATTGAGCAGCCCAAGCAGCGGGGCATGCGCTTCCGCTACAAGTGCGAGGGG
CGCTCCGCGGGCAGCATCCCAGGCGAGAGGAGCACAGATACCACCAAGACCCACCCCACC
ATCAAGATCAATGGCTACACAGGACCAGGGACAGTGCGCATCTCCCTGGTCACCAAGGAC
CCTCCTCACCGGCCTCACCCCCACGAGCTTGTAGGAAAGGACTGCCGGGATGGCTTCTAT
GAGGCTGAGCTCTGCCCGGACCGCTGCATCCACAGTTTCCAGAACCTGGGAATCCAGTGT
GTGAAGAAGCGGGACCTGGAGCAGGCTATCAGTCAGCGCATCCAGACCAACAACAACCCC
TTCCAAGAAGAGCAGCGTGGGGACTACGACCTGAATGCTGTGCGGCTCTGCTTCCAGGTG
ACAGTGCGGGACCCATCAGGCAGGCCCCTCCGCCTGCCGCCTGTCCTTTCTCATCCCATC
TTTGACAATCGTGCCCCCAACACTGCCGAGCTCAAGATCTGCCGAGTGAACCGAAACTCT
GGCAGCTGCCTCGGTGGGGATGAGATCTTCCTACTGTGTGACAAGGTGCAGAAAGAGGAC
ATTGAGGTGTATTTCACGGGACCAGGCTGGGAGGCCCGAGGCTCCTTTTCGCAAGCTGAT
GTGCACCGACAAGTGGCCATTGTGTTCCGGACCCCTCCCTACGCAGACCCCAGCCTGCAG
GCTCCTGTGCGTGTCTCCATGCAGCTGCGGCGGCCTTCCGACCGGGAGCTCAGTGAGCCC
ATGGAATTCCAGTACCTGCCAGATACAGACGATCGTCACCGGATTGAGGAGAAACGTAAA
AGGACATATGAGACCTTCAAGAGCATCATGAAGAAGAGTCCTTTCAGCGGACCCACCGAC
CCCCGGCCTCCACCTCGACGCATTGCTGTGCCTTCCCGCAGCTCAGCTTCTGTCCCCAAG
CCAGCACCCCAGCCCTATCCCTTTACGTCATCCCTGAGCACCATCAACTATGATGAGTTT
CCCACCATGGTGTTTCCTTCTGGGCAGATCAGCCAGGCCTCGGCCTTGGCCCCGGCCCCT
CCCCAAGTCCTGCCCCAGGCTCCAGCCCCTGCCCCTGCTCCAGCCATGGTATCAGCTCTG
GCCCAGGCCCCAGCCCCTGTCCCAGTCCTAGCCCCAGGCCCTCCTCAGGCTGTGGCCCCA
CCTGCCCCCAAGCCCACCCAGGCTGGGGAAGGAACGCTGTCAGAGGCCCTGCTGCAGCTG
CAGTTTGATGATGAAGACCTGGGGGCCTTGCTTGGCAACAGCACAGACCCAGCTGTGTTC
ACAGACCTGGCATCCGTCGACAACTCCGAGTTTCAGCAGCTGCTGAACCAGGGCATACCT
GTGGCCCCCCACACAACTGAGCCCATGCTGATGGAGTACCCTGAGGCTATAACTCGCCTA
GTGACAGGGGCCCAGAGGCCCCCCGACCCAGCTCCTGCTCCACTGGGGGCCCCGGGGCTC
CCCAATGGCCTCCTTTCAGGAGATGAAGACTTCTCCTCCATTGCGGACATGGACTTCTCA
GCCCTGCTGAGTCAGATCAGCTCCTAA
Chromosome Location
11
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ04206
UniProtKB Entry NameTF65_HUMAN
HGNC IDHGNC:9955
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB08908Dimethyl fumarateapproved, investigationalunknownDetails
DB14059SC-236experimental, investigationalyesinhibitorDetails