Lanosterol synthase

Details

Name
Lanosterol synthase
Synonyms
  • 2,3-epoxysqualene--lanosterol cyclase
  • 5.4.99.7
  • OSC
  • Oxidosqualene--lanosterol cyclase
Gene Name
ERG7
Organism
Yeast
Amino acid sequence
>lcl|BSEQ0020786|Lanosterol synthase
MYYSEEIGLPKTDISRWRLRSDALGRETWHYLSQSECESEPQSTFVQWLLESPDFPSPPS
SDIHTSGEAARKGADFLKLLQLDNGIFPCQYKGPMFMTIGYVTANYYSKTEIPEPYRVEM
IRYIVNTAHPVDGGWGLHSVDKSTCFGTTMNYVCLRLLGMEKDHPVLVKARKTLHRLGGA
IKNPHWGKAWLSILNLYEWEGVNPAPPELWRLPYWLPIHPAKWWVHTRAIYLPLGYTSAN
RVQCELDPLLKEIRNEIYVPSQLPYESIKFGNQRNNVCGVDLYYPHTKILDFANSILSKW
EAVRPKWLLNWVNKKVYDLIVKEYQNTEYLCIAPVSFAFNMVVTCHYEGSESENFKKLQN
RMNDVLFHGPQGMTVMGTNGVQVWDAAFMVQYFFMTGLVDDPKYHDMIRKSYLFLVRSQF
TENCVDGSFRDRRKGAWPFSTKEQGYTVSDCTAEAMKAIIMVRNHASFADIRDEIKDENL
FDAVEVLLQIQNVGEWEYGSFSTYEGIKAPLLLEKLNPAEVFNNIMVEYPYVECTDSSVL
GLTYFAKYYPDYKPELIQKTISSAIQYILDSQDNIDGSWYGCWGICYTYASMFALEALHT
VGLDYESSSAVKKGCDFLISKQLPDGGWSESMKGCETHSYVNGENSLVVQSAWALIGLIL
GNYPDEEPIKRGIQFLMKRQLPTGEWKYEDIEGVFNHSCAIEYPSYRFLFPIKALGLYKN
KYGDKVLV
Number of residues
728
Molecular Weight
83713.975
Theoretical pI
Not Available
GO Classification
Functions
lanosterol synthase activity
Processes
ergosterol biosynthetic process
General Function
Lanosterol synthase activity
Specific Function
Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0020787|Lanosterol synthase (ERG7)
ATGTATTATTCAGAGGAAATTGGTCTTCCCAAAACTGATATTTCAAGATGGAGGTTACGA
AGTGACGCTCTTGGTAGGGAAACATGGCATTATCTATCACAATCTGAATGTGAAAGTGAA
CCACAATCAACATTTGTCCAATGGCTTTTAGAGTCGCCAGATTTTCCATCTCCGCCATCG
TCAGATATTCATACTTCAGGCGAGGCAGCAAGAAAGGGAGCTGATTTTTTGAAACTATTG
CAATTGGATAATGGTATCTTCCCCTGCCAGTACAAAGGTCCAATGTTTATGACAATTGGC
TATGTAACTGCTAATTATTATAGCAAGACTGAGATACCTGAGCCGTATAGAGTTGAGATG
ATACGTTATATTGTCAACACTGCACACCCAGTCGATGGTGGTTGGGGACTTCATTCTGTT
GATAAATCTACTTGTTTTGGGACAACCATGAATTATGTATGTCTCCGGTTATTAGGAATG
GAAAAGGATCATCCAGTTTTGGTTAAGGCGAGAAAAACATTACATCGTTTGGGTGGTGCC
ATTAAGAATCCACATTGGGGTAAGGCTTGGCTATCTATTTTGAATTTATATGAATGGGAG
GGTGTGAACCCAGCTCCACCAGAACTTTGGAGATTACCGTACTGGTTACCAATTCATCCA
GCGAAATGGTGGGTACATACTAGGGCTATCTATTTGCCATTGGGATATACGTCTGCAAAC
AGAGTTCAATGTGAGCTTGATCCACTTTTAAAAGAGATCAGAAATGAAATTTACGTTCCA
AGTCAATTACCTTATGAGTCAATCAAATTTGGTAACCAGAGAAATAATGTTTGTGGTGTC
GATTTATATTACCCACATACAAAGATTCTTGATTTTGCAAATTCTATATTGAGTAAATGG
GAAGCTGTTAGACCTAAGTGGTTATTGAATTGGGTTAACAAGAAAGTTTATGATTTAATT
GTAAAGGAGTATCAGAATACAGAGTACTTGTGTATTGCTCCTGTGAGTTTTGCCTTCAAT
ATGGTTGTGACGTGTCATTATGAGGGCTCTGAATCAGAAAACTTTAAGAAACTCCAAAAC
AGAATGAACGATGTTTTGTTTCATGGACCTCAGGGAATGACTGTTATGGGGACAAATGGT
GTACAAGTTTGGGATGCCGCCTTTATGGTACAGTACTTTTTCATGACAGGCTTAGTTGAT
GACCCAAAATATCACGATATGATCAGAAAGAGTTATTTATTTTTAGTGAGATCTCAATTT
ACAGAAAATTGTGTCGATGGAAGTTTCAGAGATAGACGTAAAGGTGCTTGGCCATTTAGT
ACTAAGGAACAAGGATATACTGTTAGTGACTGTACTGCAGAAGCAATGAAGGCTATTATT
ATGGTTAGGAATCATGCAAGTTTTGCTGACATCAGGGACGAAATAAAAGATGAAAACTTG
TTTGATGCTGTTGAAGTTTTGTTGCAAATTCAAAATGTGGGAGAATGGGAATATGGCTCA
TTCTCGACTTATGAAGGTATAAAAGCCCCTTTGTTGCTAGAAAAATTGAATCCTGCCGAG
GTTTTTAATAATATTATGGTGGAGTATCCATACGTGGAATGTACAGACTCTTCCGTTTTA
GGGCTTACTTACTTTGCCAAATATTACCCTGACTACAAGCCCGAATTGATTCAGAAAACT
ATTTCCTCTGCCATTCAATATATTCTTGATTCACAAGATAACATTGATGGCTCTTGGTAT
GGTTGTTGGGGAATTTGTTATACTTATGCGTCGATGTTTGCATTAGAAGCTTTGCATACA
GTTGGTCTTGATTATGAATCCTCATCAGCTGTGAAAAAAGGATGTGATTTTCTTATTTCA
AAACAACTTCCAGACGGTGGATGGTCAGAATCAATGAAAGGTTGTGAAACACACTCTTAT
GTCAATGGTGAAAACTCTCTTGTTGTTCAATCGGCTTGGGCTTTGATAGGGTTGATATTG
GGAAATTATCCTGATGAAGAGCCAATCAAAAGAGGAATTCAATTTTTGATGAAACGACAA
TTACCGACTGGTGAGTGGAAGTATGAAGATATTGAAGGTGTATTTAATCACAGTTGTGCA
ATAGAATATCCTTCATATAGGTTTTTATTTCCAATTAAGGCATTAGGTTTATATAAAAAC
AAGTATGGTGATAAAGTGTTAGTTTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ04782
UniProtKB Entry NameERG7_CANAL
General References
  1. Roessner CA, Min C, Hardin SH, Harris-Haller LW, McCollum JC, Scott AI: Sequence of the Candida albicans erg7 gene. Gene. 1993 May 15;127(1):149-50. [Article]
  2. Jones T, Federspiel NA, Chibana H, Dungan J, Kalman S, Magee BB, Newport G, Thorstenson YR, Agabian N, Magee PT, Davis RW, Scherer S: The diploid genome sequence of Candida albicans. Proc Natl Acad Sci U S A. 2004 May 11;101(19):7329-34. Epub 2004 May 3. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00239OxiconazoleapprovedyesinhibitorDetails