Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Details

Name
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
Synonyms
  • 2.4.2.21
  • N(1)-alpha-phosphoribosyltransferase
  • NN:DBI PRT
Gene Name
cobT
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Amino acid sequence
>lcl|BSEQ0002447|Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
MQTLHALLRDIPAPDAEAMARAQQHIDGLLKPPGSLGRLETLAVQLAGMPGLNGTPQVGE
KAVLVMCADHGVWDEGVAVSPKIVTAIQAANMTRGTTGVCVLAAQAGAKVHVIDVGIDAE
PIPGVVNMRVARGCGNIAVGPAMSRLQAEALLLEVSRYTCDLAQRGVTLFGVGELGMANT
TPAAAMVSVFTGSDAKEVVGIGANLPPSRIDNKVDVVRRAIAINQPNPRDGIDVLSKVGG
FDLVGMTGVMLGAARCGLPVLLDGFLSYSAALAACQIAPAVRPYLIPSHFSAEKGARIAL
AHLSMEPYLHMAMRLGEGSGAALAMPIVEAACAMFHNMGELAASNIVLPEGNANAT
Number of residues
356
Molecular Weight
36612.305
Theoretical pI
6.3
GO Classification
Functions
cobalamin-transporting ATPase activity / nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Processes
cobalamin biosynthetic process / nucleoside biosynthetic process
General Function
Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Specific Function
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0016358|Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (cobT)
ATGCAGACACTACACGCTTTACTCCGTGACATTCCTGCGCCGGACGCCGAGGCGATGGCG
CGTGCGCAGCAACATATTGACGGCCTGCTCAAACCGCCGGGCAGCCTGGGCAGACTGGAA
ACCTTAGCCGTTCAGCTCGCGGGTATGCCGGGTCTTAACGGTACGCCGCAGGTAGGTGAA
AAGGCGGTGCTGGTGATGTGCGCCGACCATGGCGTCTGGGATGAAGGCGTAGCGGTTTCG
CCCAAAATCGTGACGGCGATTCAGGCGGCGAATATGACGCGGGGAACAACCGGCGTATGC
GTGCTTGCCGCTCAGGCCGGTGCGAAGGTGCATGTCATTGATGTCGGTATTGATGCCGAA
CCTATTCCTGGCGTAGTTAATATGCGCGTCGCGCGCGGCTGCGGAAATATTGCCGTTGGC
CCGGCGATGAGTCGCTTGCAGGCTGAGGCGCTTTTGCTGGAGGTTTCCCGCTACACCTGC
GACCTGGCGCAACGCGGCGTGACCTTATTTGGCGTAGGGGAGCTGGGAATGGCGAACACT
ACGCCAGCCGCCGCGATGGTCAGCGTTTTTACAGGAAGTGATGCAAAAGAGGTGGTGGGG
ATTGGCGCGAATCTTCCGCCTTCCCGCATCGATAATAAAGTGGACGTCGTGCGGCGGGCG
ATTGCGATTAATCAGCCCAATCCGCGCGACGGCATTGATGTGTTGTCGAAGGTGGGTGGT
TTTGATCTGGTCGGGATGACCGGCGTGATGCTTGGCGCGGCAAGGTGTGGCTTACCCGTA
TTGCTGGATGGCTTTCTTTCCTACTCGGCAGCGCTGGCGGCCTGTCAGATTGCGCCTGCG
GTGAGACCTTATCTGATCCCGTCGCACTTTTCGGCGGAAAAGGGCGCCCGCATCGCGCTC
GCGCATTTGTCTATGGAACCCTATTTGCATATGGCGATGCGGTTAGGTGAAGGAAGCGGC
GCGGCGCTGGCGATGCCGATCGTGGAAGCCGCGTGCGCCATGTTCCACAACATGGGGGAG
TTGGCGGCCAGTAATATTGTCCTGCCGGAGGGGAACGCAAACGCAACATAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ05603
UniProtKB Entry NameCOBT_SALTY
GenBank Protein ID535767
GenBank Gene IDL35477
General References
  1. Chen P, Ailion M, Weyand N, Roth J: The end of the cob operon: evidence that the last gene (cobT) catalyzes synthesis of the lower ligand of vitamin B12, dimethylbenzimidazole. J Bacteriol. 1995 Mar;177(6):1461-9. [Article]
  2. McClelland M, Sanderson KE, Spieth J, Clifton SW, Latreille P, Courtney L, Porwollik S, Ali J, Dante M, Du F, Hou S, Layman D, Leonard S, Nguyen C, Scott K, Holmes A, Grewal N, Mulvaney E, Ryan E, Sun H, Florea L, Miller W, Stoneking T, Nhan M, Waterston R, Wilson RK: Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature. 2001 Oct 25;413(6858):852-6. [Article]
  3. Roth JR, Lawrence JG, Rubenfield M, Kieffer-Higgins S, Church GM: Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium. J Bacteriol. 1993 Jun;175(11):3303-16. [Article]
  4. Cheong CG, Escalante-Semerena JC, Rayment I: The three-dimensional structures of nicotinate mononucleotide:5,6- dimethylbenzimidazole phosphoribosyltransferase (CobT) from Salmonella typhimurium complexed with 5,6-dimethybenzimidazole and its reaction products determined to 1.9 A resolution. Biochemistry. 1999 Dec 7;38(49):16125-35. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01688P-CresolexperimentalunknownDetails
DB017262-AminophenolexperimentalunknownDetails
DB02030Alpha-Ribazole-5'-PhosphateexperimentalunknownDetails
DB021632,5-XylidineexperimentalunknownDetails
DB02382NamnexperimentalunknownDetails
DB00173Adenineapproved, nutraceuticalunknownDetails
DB025915,6-DimethylbenzimidazoleexperimentalunknownDetails
DB027707-alpha-D-Ribofuranosyl-2-aminopurine-5'-phosphateexperimentalunknownDetails
DB02819Mono-[3,4-Dihydroxy-5-(5-Methyl-Benzoimidazol-1-Yl)-Tetrahydor-Furan-2-Ylmethyl] EsterexperimentalunknownDetails
DB02905N7-(5'-Phospho-alpha-ribosyl)-2-hydroxypurineexperimentalunknownDetails
DB02962Benzimidazoleexperimental, investigationalunknownDetails
DB030183,4-dimethylanilineexperimentalunknownDetails
DB03079Alpha-Ribazole-5'-Phosphate DerivativeexperimentalunknownDetails
DB031775-methylbenzimidazoleexperimentalunknownDetails
DB031804,5-Dimethyl-1,2-phenylenediamineexperimentalunknownDetails
DB032007-Alpha-D-Ribofuranosyl-Purine-5'-PhosphateexperimentalunknownDetails
DB03366Imidazoleexperimental, investigationalunknownDetails
DB03887Alpha-Adenosine MonophosphateexperimentalunknownDetails
DB040523,4-XylenolexperimentalunknownDetails
DB041204-Methyl-1,2-BenzenediolexperimentalunknownDetails
DB041305-MethoxybenzimidazoleexperimentalunknownDetails
DB04176Phosporic Acid Mono-[3,4-Dihydroxy-5-(5-Methoxy-Benzoimidazol-1-Yl)-Tetrahydro-Furan-2-Ylmethyl] EsterexperimentalunknownDetails
DB04532IndoleexperimentalunknownDetails
DB045332-Amino-4-methylphenolexperimentalunknownDetails