Sodium-dependent phosphate transport protein 2A
Details
- Name
- Sodium-dependent phosphate transport protein 2A
- Synonyms
- Na(+)-dependent phosphate cotransporter 2A
- Na(+)/Pi cotransporter 2A
- NaPi-2a
- NaPi-3
- NPT2
- SLC17A2
- Sodium-phosphate transport protein 2A
- Sodium/phosphate cotransporter 2A
- Solute carrier family 34 member 1
- Gene Name
- SLC34A1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049438|Sodium-dependent phosphate transport protein 2A MLSYGERLGSPAVSPLPVRGGHVMRGTAFAYVPSPQVLHRIPGTSAYAFPSLGPVALAEH TCPCGEVLERHEPLPAKLALEEEQKPESRLVPKLRQAGAMLLKVPLMLTFLYLFVCSLDM LSSAFQLAGGKVAGDIFKDNAILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLE VSSAIPIIMGSNIGTSVTNTIVALMQAGDRTDFRRAFAGATVHDCFNWLSVLVLLPLEAA TGYLHHITRLVVASFNIHGGRDAPDLLKIITEPFTKLIIQLDESVITSIATGDESLRNHS LIQIWCHPDSLQAPTSMSRAEANSSQTLGNATMEKCNHIFVDTGLPDLAVGLILLAGSLV LLCTCLILLVKMLNSLLKGQVAKVIQKVINTDFPAPFTWVTGYFAMVVGASMTFVVQSSS VFTSAITPLIGLGVISIERAYPLTLGSNIGTTTTAILAALASPREKLSSAFQIALCHFFF NISGILLWYPVPCTRLPIRMAKALGKRTAKYRWFAVLYLLVCFLLLPSLVFGISMAGWQV MVGVGTPFGALLAFVVLINVLQSRSPGHLPKWLQTWDFLPRWMHSLKPLDHLITRATLCC ARPEPRSPPLPPRVFLEELPPATPSPRLALPAHHNATRL
- Number of residues
- 639
- Molecular Weight
- 68936.53
- Theoretical pI
- Not Available
- GO Classification
- FunctionsPDZ domain binding / protein complex binding / protein homodimerization activity / sodium / sodium-dependent phosphate transmembrane transporter activityProcessesarsenate ion transmembrane transport / cellular phosphate ion homeostasis / cellular protein metabolic process / cellular response to metal ion / cellular response to parathyroid hormone stimulus / cellular response to staurosporine / dentinogenesis / gentamycin metabolic process / glycoprotein metabolic process / indole metabolic process / kidney development / ossification / phosphate ion homeostasis / phosphate ion transport / positive regulation of membrane potential / positive regulation of phosphate transmembrane transport / positive regulation of sodium-dependent phosphate transport / protein homooligomerization / response to cadmium ion / response to drug / response to estradiol / response to growth hormone / response to lead ion / response to magnesium ion / response to mercury ion / response to potassium ion / response to thyroid hormone / response to vitamin A / tricarboxylic acid metabolic processComponentsapical plasma membrane / brush border / brush border membrane / cell surface / cytoplasm / endosome / integral component of plasma membrane / membrane raft / perinuclear region of cytoplasm / plasma membrane / vesicle
- General Function
- Sodium:phosphate symporter activity
- Specific Function
- Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx.
- Pfam Domain Function
- Na_Pi_cotrans (PF02690)
- Transmembrane Regions
- 104-125 146-163 166-185 348-370 413-436 467-487 514-534 540-561
- Cellular Location
- Apical cell membrane
- Gene sequence
>lcl|BSEQ0049439|Sodium-dependent phosphate transport protein 2A (SLC34A1) ATGTTGTCCTACGGAGAGAGGCTGGGGTCCCCTGCTGTCTCCCCACTCCCAGTCCGTGGG GGGCATGTGATGCGAGGGACGGCCTTTGCCTACGTGCCCAGCCCTCAGGTCCTACACAGG ATCCCGGGGACCTCTGCCTATGCCTTCCCCAGCCTGGGCCCTGTGGCCCTTGCTGAGCAC ACCTGCCCCTGTGGGGAGGTCCTGGAGCGCCATGAACCACTGCCTGCCAAGCTGGCCCTG GAGGAGGAGCAGAAGCCAGAGTCCAGGCTGGTCCCCAAGCTGCGCCAGGCTGGCGCCATG CTGCTCAAGGTGCCACTGATGCTCACCTTCCTCTACCTCTTCGTCTGCTCCCTGGACATG CTCAGCTCGGCCTTCCAGCTGGCTGGAGGGAAGGTGGCTGGTGACATCTTCAAGGATAAC GCCATCCTGTCCAACCCGGTGGCCGGGCTGGTGGTGGGGATCCTGGTGACCGTGCTGGTG CAGAGCTCCAGCACCTCCACATCCATCATCGTCAGCATGGTCTCCTCTGGCTTGCTGGAG GTGAGCTCTGCCATCCCCATCATCATGGGCTCCAACATCGGCACCTCTGTCACCAACACC ATCGTGGCCCTGATGCAGGCGGGGGACAGGACTGACTTCCGGCGGGCCTTCGCGGGGGCC ACGGTGCATGACTGCTTTAACTGGCTGTCAGTGCTGGTCCTGCTGCCCCTGGAGGCTGCC ACTGGCTACCTGCACCACATCACTCGACTTGTGGTGGCCTCCTTCAACATCCATGGTGGC CGTGATGCTCCTGACCTGCTCAAGATCATCACAGAGCCCTTCACGAAGCTCATCATCCAG CTGGACGAGTCTGTGATAACCAGCATTGCCACTGGTGATGAGTCCCTGAGGAACCACAGT CTCATCCAGATCTGGTGCCACCCAGACTCCTTACAGGCTCCCACCTCCATGTCCAGAGCA GAGGCCAACTCCAGCCAGACCCTTGGAAATGCCACCATGGAGAAATGCAACCACATCTTT GTGGACACTGGCCTACCGGACCTGGCTGTGGGGCTCATCCTGCTGGCAGGATCCCTGGTG CTGCTGTGCACCTGCCTCATCCTCCTAGTCAAGATGCTCAACTCCCTGCTCAAGGGCCAA GTGGCCAAGGTCATCCAGAAGGTCATCAATACGGACTTCCCTGCCCCCTTCACCTGGGTC ACAGGCTACTTTGCCATGGTGGTGGGCGCCAGCATGACCTTCGTGGTCCAGAGCAGTTCT GTGTTCACCTCGGCCATCACCCCACTCATCGGTCTTGGTGTGATCAGCATTGAGAGGGCC TACCCGCTCACACTGGGTTCCAACATCGGCACCACCACCACGGCCATCCTGGCTGCCCTG GCCAGCCCCAGGGAGAAGCTGTCCAGCGCTTTCCAGATTGCCCTCTGTCACTTCTTCTTC AACATCTCGGGTATCCTTCTGTGGTACCCGGTGCCCTGCACACGCCTGCCCATCCGCATG GCCAAGGCGCTGGGGAAACGCACGGCCAAGTACCGCTGGTTTGCCGTCCTCTATCTCCTT GTCTGCTTCCTGCTGCTGCCCTCACTGGTGTTTGGCATCTCCATGGCAGGCTGGCAGGTC ATGGTAGGTGTGGGCACGCCCTTCGGGGCCCTGCTGGCCTTCGTGGTGCTCATCAATGTC CTGCAGAGTCGGAGTCCCGGGCACCTGCCCAAGTGGTTACAGACATGGGACTTCCTGCCT CGCTGGATGCACTCCCTGAAGCCCCTGGACCACCTCATCACCCGCGCCACCCTATGCTGT GCCAGGCCTGAGCCCCGCTCACCCCCGCTGCCCCCCAGGGTCTTCCTGGAGGAGCTACCC CCTGCCACACCCTCCCCCCGTCTTGCACTGCCTGCTCACCACAATGCCACCCGCCTCTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q06495 UniProtKB Entry Name NPT2A_HUMAN HGNC ID HGNC:11019 - General References
- Magagnin S, Werner A, Markovich D, Sorribas V, Stange G, Biber J, Murer H: Expression cloning of human and rat renal cortex Na/Pi cotransport. Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):5979-83. [Article]
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- Schmutz J, Martin J, Terry A, Couronne O, Grimwood J, Lowry S, Gordon LA, Scott D, Xie G, Huang W, Hellsten U, Tran-Gyamfi M, She X, Prabhakar S, Aerts A, Altherr M, Bajorek E, Black S, Branscomb E, Caoile C, Challacombe JF, Chan YM, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Lopez F, Lou Y, Martinez D, Medina C, Morgan J, Nandkeshwar R, Noonan JP, Pitluck S, Pollard M, Predki P, Priest J, Ramirez L, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wheeler J, Wu K, Yang J, Dickson M, Cheng JF, Eichler EE, Olsen A, Pennacchio LA, Rokhsar DS, Richardson P, Lucas SM, Myers RM, Rubin EM: The DNA sequence and comparative analysis of human chromosome 5. Nature. 2004 Sep 16;431(7006):268-74. [Article]
- Courbebaisse M, Leroy C, Bakouh N, Salaun C, Beck L, Grandchamp B, Planelles G, Hall RA, Friedlander G, Prie D: A new human NHERF1 mutation decreases renal phosphate transporter NPT2a expression by a PTH-independent mechanism. PLoS One. 2012;7(4):e34764. doi: 10.1371/journal.pone.0034764. Epub 2012 Apr 10. [Article]
- Schlingmann KP, Ruminska J, Kaufmann M, Dursun I, Patti M, Kranz B, Pronicka E, Ciara E, Akcay T, Bulus D, Cornelissen EA, Gawlik A, Sikora P, Patzer L, Galiano M, Boyadzhiev V, Dumic M, Vivante A, Kleta R, Dekel B, Levtchenko E, Bindels RJ, Rust S, Forster IC, Hernando N, Jones G, Wagner CA, Konrad M: Autosomal-Recessive Mutations in SLC34A1 Encoding Sodium-Phosphate Cotransporter 2A Cause Idiopathic Infantile Hypercalcemia. J Am Soc Nephrol. 2016 Feb;27(2):604-14. doi: 10.1681/ASN.2014101025. Epub 2015 Jun 5. [Article]
- Prie D, Huart V, Bakouh N, Planelles G, Dellis O, Gerard B, Hulin P, Benque-Blanchet F, Silve C, Grandchamp B, Friedlander G: Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporter. N Engl J Med. 2002 Sep 26;347(13):983-91. [Article]
- Magen D, Berger L, Coady MJ, Ilivitzki A, Militianu D, Tieder M, Selig S, Lapointe JY, Zelikovic I, Skorecki K: A loss-of-function mutation in NaPi-IIa and renal Fanconi's syndrome. N Engl J Med. 2010 Mar 25;362(12):1102-9. doi: 10.1056/NEJMoa0905647. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB09449 Sodium phosphate, monobasic approved no substrate Details DB11348 Calcium Phosphate approved no substrate Details DB14481 Calcium phosphate dihydrate approved no Details DB14502 Sodium phosphate, dibasic approved no Details DB14503 Sodium phosphate, monobasic, unspecified form approved no Details