Penicillin-binding protein 1A

Details

Name
Penicillin-binding protein 1A
Synonyms
  • PBP-1a
  • ponA
Gene Name
mrcA
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Amino acid sequence
>lcl|BSEQ0017184|Penicillin-binding protein 1A
MRLLKFLWWTCVTLICGVLLSFSGAYLYLSPSLPSVEALRNVQLQIPLKVYSEDGKLISE
FGEMRRTPIRFADIPQDFIHALLSAEDDNFANHYGVDVKSLMRAAAQLLKSGHIQTGGST
ITMQVAKNYFLTNERSFSRKINEILLALQIERQLTKDEILELYVNKIYLGNRAYGIEAAA
QVYYGKPIKDLSLAEMAMIAGLPKAPSRYNPLVNPTRSTERRNWILERMLKLGFIDQQRY
QAAVEEPINASYHVQTPELNAPYIAEMARAEMVGRYGSEAYTEGYKVITTVRSDLQNAAS
QSVRDGLIDYDQRHGYRGPETRLPGQTRDAWLKHLGQQRSIGGLEPAIVTQVEKSGIMVM
TRDGKEEAVTWDSMKWARPFLSNNSMGPMPRQPADVAQAGDQIRVQRQEDGTLRFVQIPA
AQSALISLDPKDGAIRSLVGGFSFEQSNYNRAIQAKRQPGSSFKPFIYSAALDNGFTAAS
LVNDAPIVFVDEYLDKVWRPKNDTNTFLGPIPLREALYKSRNMVSIRVLQGLGIERAISY
ITKFGFQRDELPRNFSLALGTATVTPMEIAGAWSVFANGGYKVNPYVIERIESRDGQVLY
QANPPRVPVEEQVAADAEDAGNPGDPEHPESAEGEGSIEAQQVAAKAQTTFEPTPAERII
DARTAYIMTSMLQDVIKRGTGRRALALKRTDLAGKTGTTNDSKDGWFSGYNSDYVTSVWV
GFDQPETLGRREYGGTVALPIWIRYMGFALKDKPMHTMAEPPGIVSLRIDPVTGRSAAPG
TPGAYFEMFKNEDTPPSVNELPPGSFPGSPLPDDEGAPIDLF
Number of residues
822
Molecular Weight
91198.715
Theoretical pI
6.01
GO Classification
Functions
hydrolase activity / penicillin binding / transferase activity, transferring glycosyl groups
Processes
cell wall organization / peptidoglycan biosynthetic process / regulation of cell shape / response to antibiotic
Components
integral component of membrane / plasma membrane
General Function
Transferase activity, transferring glycosyl groups
Specific Function
Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) (By similarity).
Pfam Domain Function
Transmembrane Regions
6-26
Cellular Location
Cell inner membrane
Gene sequence
>lcl|BSEQ0017185|Penicillin-binding protein 1A (mrcA)
ATGCGCCTGCTGAAGTTCCTGTGGTGGACTTGCGTCACCCTGATTTGTGGAGTGCTGCTC
AGTTTCAGCGGCGCCTATCTCTATCTGAGTCCCAGCCTGCCCTCGGTGGAAGCTCTGCGT
AACGTCCAGCTGCAGATCCCCCTCAAGGTCTACAGCGAGGACGGCAAGCTGATCTCCGAG
TTCGGCGAGATGCGCCGGACGCCGATCCGCTTCGCCGACATCCCGCAGGACTTCATCCAT
GCCCTGCTGTCCGCCGAGGACGACAATTTCGCCAACCATTATGGCGTCGATGTGAAAAGC
CTAATGCGCGCCGCCGCGCAATTATTGAAAAGCGGTCACATCCAGACTGGCGGCAGCACC
ATCACCATGCAGGTAGCGAAGAACTACTTCCTTACCAATGAAAGAAGCTTCTCGCGAAAG
ATCAATGAAATCCTCCTGGCCCTGCAGATCGAGCGACAGCTGACCAAGGACGAGATCCTC
GAGCTCTACGTCAACAAGATCTACCTGGGCAACCGTGCCTATGGCATCGAGGCTGCCGCA
CAGGTCTATTACGGCAAGCCGATCAAAGACTTGAGCCTGGCCGAGATGGCGATGATCGCC
GGCCTGCCGAAAGCGCCCTCGCGCTACAACCCGCTGGTCAACCCGACCCGCAGTACGGAG
CGGCGCAACTGGATCCTCGAGCGCATGCTCAAGCTCGGCTTCATCGACCAGCAACGCTAC
CAGGCCGCCGTCGAGGAGCCGATCAACGCCTCCTACCACGTGCAGACCCCCGAACTGAAT
GCGCCCTACATCGCCGAGATGGCCCGTGCCGAGATGGTCGGCCGCTACGGCAGCGAGGCC
TATACCGAGGGCTACAAGGTCATCACCACGGTCCGCAGCGACCTGCAGAACGCCGCCAGC
CAATCGGTCCGCGACGGCCTCATCGACTATGACCAGCGCCACGGCTACCGCGGCCCGGAG
ACCCGCCTGCCGGGCCAGACCCGCGACGCCTGGCTCAAGCACCTGGGCCAGCAGCGCAGC
ATCGGCGGCCTGGAGCCGGCGATCGTCACCCAGGTGGAAAAGAGCGGGATCATGGTGATG
ACCCGCGACGGCAAGGAAGAAGCCGTGACCTGGGACAGCATGAAATGGGCACGCCCCTTC
CTCAGCAACAACAGCATGGGCCCGATGCCGCGCCAGCCCGCCGACGTGGCCCAGGCCGGC
GACCAGATCCGCGTGCAGCGCCAGGAAGACGGCACCCTGCGCTTCGTACAGATTCCCGCC
GCACAGAGCGCGCTGATCTCCCTTGACCCGAAGGACGGGGCGATCCGCTCGCTGGTCGGC
GGCTTCTCCTTCGAGCAGAGCAACTACAACCGCGCGATCCAGGCCAAGCGCCAGCCGGGC
TCCAGTTTCAAGCCGTTCATCTACAGCGCGGCCCTGGACAACGGCTTCACCGCCGCCAGC
CTGGTCAACGATGCGCCGATCGTGTTCGTCGACGAGTACCTGGACAAGGTCTGGCGACCG
AAGAACGACACCAATACCTTCCTCGGCCCGATCCCGCTGCGCGAAGCCCTGTACAAGTCC
CGCAACATGGTCTCGATCCGCGTCCTGCAGGGCCTGGGCATCGAGCGGGCGATCAGCTAC
ATCACCAAGTTCGGCTTCCAGCGCGACGAACTGCCGCGCAACTTCTCCCTGGCCCTGGGT
ACCGCGACAGTCACACCGATGGAAATCGCCGGCGCCTGGAGCGTATTCGCCAACGGCGGC
TACAAGGTCAATCCGTACGTCATCGAACGCATCGAGAGCCGCGACGGACAGGTGCTGTAC
CAGGCCAATCCGCCCCGCGTGCCGGTGGAAGAACAGGTCGCTGCGGATGCGGAAGACGCC
GGGAATCCTGGTGACCCCGAGCATCCGGAGAGCGCCGAAGGCGAAGGTTCGATCGAAGCC
CAGCAAGTCGCCGCCAAGGCCCAGACCACCTTCGAGCCGACCCCGGCCGAGCGGATCATC
GATGCCCGTACCGCCTATATCATGACCAGCATGCTGCAGGACGTGATCAAGCGCGGTACC
GGGCGTCGCGCCCTGGCGCTGAAGCGCACCGACCTGGCCGGCAAGACCGGCACCACCAAC
GATTCCAAGGATGGCTGGTTCTCCGGCTACAACTCCGACTACGTGACCAGCGTCTGGGTC
GGCTTCGACCAGCCGGAGACCCTGGGTCGCCGCGAGTACGGCGGTACCGTCGCGCTGCCG
ATCTGGATCAGGTACATGGGCTTCGCCCTCAAGGACAAGCCGATGCACACCATGGCCGAG
CCGCCAGGCATCGTCAGCCTGCGCATCGACCCGGTGACCGGCCGTTCGGCCGCGCCGGGC
ACTCCCGGCGCCTATTTCGAGATGTTCAAGAACGAGGATACCCCGCCCTCGGTCAATGAA
CTGCCGCCAGGCAGCTTCCCTGGCAGCCCGCTGCCGGATGACGAAGGCGCGCCGATCGAC
CTGTTCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ07806
UniProtKB Entry NamePBPA_PSEAE
GenBank Protein ID1763284
GenBank Gene IDU73780
General References
  1. Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. [Article]
  2. Martin PR, Hobbs M, Free PD, Jeske Y, Mattick JS: Characterization of pilQ, a new gene required for the biogenesis of type 4 fimbriae in Pseudomonas aeruginosa. Mol Microbiol. 1993 Aug;9(4):857-68. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01329Cefoperazoneapproved, investigationalyesinhibitorDetails
DB00430CefpiramideapprovedyesinhibitorDetails
DB14879Cefiderocolapproved, investigationalyesinhibitorDetails