Unconventional myosin-Ie
Details
- Name
- Unconventional myosin-Ie
- Synonyms
- MYO1C
- Myosin-Ic
- Unconventional myosin 1E
- Gene Name
- MYO1E
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0013168|Unconventional myosin-Ie MGSKGVYQYHWQSHNVKHSGVDDMVLLSKITENSIVENLKKRYMDDYIFTYIGSVLISVN PFKQMPYFGEKEIEMYQGAAQYENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTV AAKYIMSYISRVSGGGTKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSP GGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASAEQKHSLGITSMDYYYYLSL SGSYKVDDIDDRREFQETLHAMNVIGIFAEEQTLVLQIVAGILHLGNISFKEVGNYAAVE SEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGGKSESIHVTLNVEQACYTRDALAKALH ARVFDFLVDSINKAMEKDHEEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELT LKAEQEEYVQEGIRWTPIEYFNNKIVCDLIENKVNPPGIMSILDDVCATMHAVGEGADQT LLQKLQMQIGSHEHFNSWNQGFIIHHYAGKVSYDMDGFCERNRDVLFMDLIELMQSSELP FIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPRDWEE SRVKHQVEYLGLKENIRVRRAGYAYRRIFQKFLQRYAILTKATWPSWQGEEKQGVLHLLQ SVNMDSDQFQLGRSKVFIKAPESLFLLEEMRERKYDGYARVIQKSWRKFVARKKYVQMRE EASDLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADTVTKYDRRFKGV KRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLKRKIEIERILSVSLSTMQDDIFILHEQE YDSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNTLELKLKKENWGPWSAGGSRQVQFH QGFGDLAVLKPSNKVLQVSIGPGLPKNSRPTRRNTTQNTGYSSGTQNANYPVRAAPPPPG YHQNGVIRNQYVPYPHAPGSQRSNQKSLYTSMARPPLPRQQSTSSDRVSQTPESLDFLKV PDQGAAGVRRQTTSRPPPAGGRPKPQPKPKPQVPQCKALYAYDAQDTDELSFNANDIIDI IKEDPSGWWTGRLRGKQGLFPNNYVTKI
- Number of residues
- 1108
- Molecular Weight
- 127061.075
- Theoretical pI
- Not Available
- GO Classification
- Functionsactin filament binding / ATP binding / ATPase activity, coupled / calmodulin binding / microfilament motor activity / motor activity / phosphatidylinositol bindingProcessesactin filament-based movement / endocytosis / glomerular basement membrane development / glomerular filtration / glomerular visceral epithelial cell development / in utero embryonic development / nitrogen compound metabolic process / platelet-derived growth factor receptor signaling pathway / post-embryonic hemopoiesis / vasculogenesisComponentsactin cytoskeleton / adherens junction / brush border / cell-cell junction / clathrin-coated vesicle / cytoplasm / cytoskeleton / extracellular exosome / myosin complex
- General Function
- Phosphatidylinositol binding
- Specific Function
- Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0013169|Unconventional myosin-Ie (MYO1E) ATGGGAAGCAAAGGTGTCTACCAGTACCACTGGCAAAGCCACAATGTCAAGCACAGTGGT GTGGACGACATGGTGCTACTGTCCAAGATCACAGAGAACTCCATCGTGGAGAATCTGAAG AAGAGATACATGGATGACTACATTTTTACATATATAGGATCTGTATTAATCTCAGTCAAC CCTTTCAAGCAGATGCCATATTTTGGGGAAAAGGAAATTGAAATGTACCAAGGAGCGGCA CAGTATGAAAACCCACCACATATCTATGCCCTTGCAGATAATATGTACAGAAACATGATC ATTGACAGAGAGAACCAGTGCGTCATTATCAGTGGTGAAAGTGGTGCTGGAAAAACAGTG GCTGCCAAATATATCATGAGCTACATCTCCAGAGTGTCTGGAGGAGGGACCAAAGTCCAG CACGTGAAGGACATTATCCTGCAGTCCAACCCGCTGCTGGAGGCCTTCGGGAACGCCAAG ACCGTCCGGAACAACAACTCCAGCCGATTTGGAAAATACTTTGAAATCCAGTTCAGTCCA GGTGGGGAACCAGATGGTGGAAAGATCTCCAACTTCCTTCTGGAAAAATCTAGGGTGGTG ATGAGGAACCCAGGAGAGCGGAGTTTTCACATATTTTACCAGCTCATCGAGGGCGCCTCT GCAGAGCAGAAACACAGCCTTGGCATCACCAGCATGGACTATTATTACTACCTGAGCCTC TCGGGCTCATACAAGGTTGATGACATTGACGACAGGCGGGAGTTTCAGGAAACTCTGCAC GCCATGAATGTGATTGGGATCTTTGCAGAAGAGCAAACGCTGGTGTTGCAGATAGTGGCG GGTATTCTCCACCTGGGAAACATCAGCTTCAAAGAAGTTGGCAACTACGCGGCTGTGGAG AGTGAAGAGTTTTTAGCTTTTCCTGCATATCTGCTAGGGATAAACCAGGACCGGTTGAAA GAAAAGCTAACAAGCCGGCAGATGGATAGCAAGTGGGGAGGCAAATCCGAATCCATCCAC GTGACCCTCAACGTAGAGCAGGCCTGTTACACCCGGGATGCGCTCGCCAAGGCCCTGCAC GCCCGGGTCTTTGATTTCTTGGTAGATTCCATCAATAAAGCCATGGAGAAAGACCATGAA GAATACAACATTGGCGTCCTAGACATCTATGGCTTTGAAATATTCCAGAAAAATGGCTTT GAACAGTTTTGTATCAATTTTGTTAATGAAAAACTGCAGCAGATTTTTATTGAACTGACA TTAAAGGCAGAACAGGAAGAATATGTTCAAGAGGGAATAAGATGGACACCCATTGAGTAC TTTAATAATAAAATCGTATGTGACCTCATAGAGAACAAAGTGAACCCTCCTGGCATCATG AGCATCCTGGATGACGTGTGCGCCACGATGCATGCGGTGGGTGAGGGGGCAGATCAGACG CTGCTCCAGAAACTTCAGATGCAGATTGGGAGTCATGAGCACTTCAACAGTTGGAACCAA GGCTTCATCATTCATCATTATGCTGGGAAGGTATCCTATGACATGGATGGCTTTTGTGAA AGGAACCGGGATGTGCTTTTTATGGATCTCATCGAGCTTATGCAGAGCAGCGAGCTGCCT TTCATAAAGTCTTTATTTCCGGAAAATCTGCAGGCTGACAAGAAAGGGCGCCCAACTACT GCCGGAAGCAAAATAAAGAAACAAGCCAATGACCTTGTGAGCACCCTGATGAAATGTACG CCCCACTACATTCGCTGCATCAAGCCAAACGAAACCAAGAAGCCCAGAGACTGGGAGGAA AGCAGGGTAAAGCATCAAGTCGAATATTTGGGTCTGAAAGAGAACATTCGAGTGAGAAGA GCTGGCTATGCCTATCGGCGCATCTTCCAAAAATTCCTACAGAGGTATGCCATTCTGACC AAAGCCACCTGGCCTTCTTGGCAGGGAGAGGAGAAGCAAGGCGTCCTGCACCTGCTGCAG TCGGTCAACATGGACAGCGACCAGTTCCAGCTGGGGAGGAGTAAAGTGTTCATCAAAGCC CCCGAGTCTCTATTTCTTTTAGAAGAGATGAGAGAGAGAAAGTATGATGGGTATGCTCGA GTGATACAGAAATCATGGAGGAAATTCGTGGCCCGGAAGAAATACGTTCAAATGAGAGAA GAAGCCTCAGACCTCTTATTGAACAAGAAGGAGAGAAGGAGAAACAGTATTAACAGGAAC TTTATAGGGGATTATATTGGGATGGAAGAGCACCCAGAACTCCAGCAGTTCGTGGGCAAG AGGGAGAAGATTGATTTCGCAGACACAGTCACCAAGTATGACAGGAGGTTCAAGGGTGTA AAGCGAGACCTGCTCCTTACCCCAAAGTGCTTGTACTTAATCGGACGAGAAAAAGTCAAA CAGGGCCCAGACAAGGGCCTGGTGAAAGAAGTCCTGAAGCGGAAAATCGAGATAGAACGG ATCTTGTCTGTGTCCCTCAGTACTATGCAGGATGACATTTTTATTCTCCATGAGCAAGAG TATGACAGTTTGCTTGAATCTGTCTTCAAAACTGAATTCCTAAGCCTCTTAGCAAAGCGT TACGAGGAGAAGACCCAGAAGCAACTACCTCTGAAATTCAGCAATACGCTTGAACTGAAG TTGAAAAAGGAAAACTGGGGCCCCTGGAGTGCAGGGGGCTCCCGGCAAGTGCAGTTCCAC CAAGGGTTTGGGGACCTGGCTGTCCTCAAGCCCAGTAACAAAGTGCTGCAGGTCAGCATC GGACCTGGACTGCCCAAGAACTCCCGTCCTACCAGAAGGAACACTACCCAAAATACAGGT TATTCCAGTGGGACTCAAAATGCCAACTACCCAGTGAGAGCTGCCCCTCCTCCCCCAGGA TACCATCAGAACGGAGTCATCAGAAACCAGTATGTGCCATATCCCCATGCTCCTGGAAGC CAGAGGTCCAATCAGAAAAGCCTGTACACCTCCATGGCCCGCCCGCCCTTGCCTCGGCAG CAGTCTACCAGTTCAGACCGAGTGTCACAGACGCCAGAGAGCCTGGATTTCCTCAAGGTC CCGGACCAGGGAGCTGCAGGGGTCAGGAGACAAACAACCAGTCGGCCTCCCCCAGCAGGG GGCAGACCCAAGCCCCAGCCCAAGCCCAAGCCTCAGGTGCCACAGTGCAAGGCTTTGTAT GCCTATGACGCTCAGGACACAGACGAACTCAGCTTTAATGCCAATGACATTATTGATATT ATCAAAGAAGATCCTTCTGGCTGGTGGACGGGTCGACTACGAGGCAAGCAGGGCCTGTTC CCCAACAACTATGTGACCAAGATCTGA
- Chromosome Location
- 15
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q12965 UniProtKB Entry Name MYO1E_HUMAN HGNC ID HGNC:7599 - General References
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- Feeser EA, Ignacio CM, Krendel M, Ostap EM: Myo1e binds anionic phospholipids with high affinity. Biochemistry. 2010 Nov 2;49(43):9353-60. doi: 10.1021/bi1012657. [Article]
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- Sanna-Cherchi S, Burgess KE, Nees SN, Caridi G, Weng PL, Dagnino M, Bodria M, Carrea A, Allegretta MA, Kim HR, Perry BJ, Gigante M, Clark LN, Kisselev S, Cusi D, Gesualdo L, Allegri L, Scolari F, D'Agati V, Shapiro LS, Pecoraro C, Palomero T, Ghiggeri GM, Gharavi AG: Exome sequencing identified MYO1E and NEIL1 as candidate genes for human autosomal recessive steroid-resistant nephrotic syndrome. Kidney Int. 2011 Aug;80(4):389-96. doi: 10.1038/ki.2011.148. Epub 2011 Jun 22. [Article]