Bleomycin hydrolase

Details

Name
Bleomycin hydrolase
Synonyms
  • 3.4.22.40
  • BH
Gene Name
BLMH
Organism
Humans
Amino acid sequence
>lcl|BSEQ0013266|Bleomycin hydrolase
MSSSGLNSEKVAALIQKLNSDPQFVLAQNVGTTHDLLDICLKRATVQRAQHVFQHAVPQE
GKPITNQKSSGRCWIFSCLNVMRLPFMKKLNIEEFEFSQSYLFFWDKVERCYFFLSAFVD
TAQRKEPEDGRLVQFLLMNPANDGGQWDMLVNIVEKYGVIPKKCFPESYTTEATRRMNDI
LNHKMREFCIRLRNLVHSGATKGEISATQDVMMEEIFRVVCICLGNPPETFTWEYRDKDK
NYQKIGPITPLEFYREHVKPLFNMEDKICLVNDPRPQHKYNKLYTVEYLSNMVGGRKTLY
NNQPIDFLKKMVAASIKDGEAVWFGCDVGKHFNSKLGLSDMNLYDHELVFGVSLKNMNKA
ERLTFGESLMTHAMTFTAVSEKDDQDGAFTKWRVENSWGEDHGHKGYLCMTDEWFSEYVY
EVVVDRKHVPEEVLAVLEQEPIILPAWDPMGALAE
Number of residues
455
Molecular Weight
52561.93
Theoretical pI
Not Available
GO Classification
Functions
aminopeptidase activity / carboxypeptidase activity / cysteine-type endopeptidase activity / cysteine-type peptidase activity
Processes
antigen processing and presentation of peptide antigen via MHC class I / protein polyubiquitination / proteolysis / response to drug / response to toxic substance
Components
cytoplasm / cytosol / extracellular exosome / nucleus
General Function
Cysteine-type peptidase activity
Specific Function
The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0013267|Bleomycin hydrolase (BLMH)
ATGAGCAGCTCGGGACTGAATTCGGAGAAGGTAGCTGCTCTGATACAGAAACTGAATTCC
GACCCCCAGTTCGTACTTGCCCAGAATGTCGGGACCACCCACGACCTGCTGGACATCTGT
CTGAAGCGGGCCACGGTGCAGCGCGCGCAGCATGTGTTCCAGCACGCCGTGCCCCAGGAG
GGCAAGCCAATCACCAACCAGAAGAGCTCAGGGCGATGCTGGATCTTTTCTTGTCTGAAT
GTTATGAGGCTTCCATTCATGAAAAAGTTAAATATTGAAGAATTTGAGTTTAGCCAATCT
TACCTGTTTTTTTGGGACAAGGTTGAACGCTGTTATTTCTTCTTGAGTGCTTTTGTGGAC
ACAGCCCAGAGAAAGGAGCCTGAGGATGGGAGGCTGGTGCAGTTTTTGCTTATGAACCCT
GCAAATGATGGTGGCCAATGGGATATGCTTGTTAATATTGTTGAAAAATATGGTGTTATC
CCTAAGAAATGCTTCCCTGAATCTTATACAACAGAGGCAACCAGAAGGATGAATGATATT
CTGAATCACAAGATGAGAGAATTCTGTATACGACTGCGGAACCTGGTACACAGTGGAGCA
ACCAAAGGAGAAATCTCGGCCACACAGGACGTCATGATGGAGGAGATATTCCGAGTGGTG
TGCATCTGTTTGGGTAATCCACCAGAGACATTCACCTGGGAATATCGAGACAAAGATAAA
AATTATCAGAAAATTGGCCCCATAACACCCTTGGAGTTTTACAGGGAACATGTCAAGCCA
CTCTTCAATATGGAAGATAAGATTTGTTTAGTGAATGACCCTAGGCCCCAGCACAAGTAC
AACAAACTTTACACAGTGGAATACTTAAGCAATATGGTTGGAGGGAGAAAAACTCTATAC
AACAACCAGCCCATTGACTTCCTGAAAAAGATGGTTGCTGCCTCCATCAAAGATGGAGAG
GCTGTGTGGTTTGGCTGTGATGTTGGAAAACACTTCAATAGCAAGCTGGGCCTCAGTGAC
ATGAATCTCTATGACCATGAGTTAGTGTTTGGTGTCTCCTTGAAGAACATGAATAAAGCG
GAGAGGCTGACTTTTGGTGAGTCACTTATGACCCACGCCATGACCTTCACTGCTGTCTCA
GAGAAGGATGATCAGGATGGTGCTTTCACAAAATGGAGAGTGGAGAATTCATGGGGTGAA
GACCATGGCCACAAAGGTTACCTGTGCATGACAGATGAGTGGTTCTCTGAGTATGTCTAC
GAAGTGGTGGTGGACAGGAAGCATGTCCCTGAAGAGGTGCTAGCTGTGTTAGAGCAGGAA
CCCATTATCCTGCCAGCATGGGACCCCATGGGAGCTTTGGCTGAGTGA
Chromosome Location
17
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ13867
UniProtKB Entry NameBLMH_HUMAN
HGNC IDHGNC:1059
General References
  1. Ferrando AA, Velasco G, Campo E, Lopez-Otin C: Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance. Cancer Res. 1996 Apr 15;56(8):1746-50. [Article]
  2. Bromme D, Rossi AB, Smeekens SP, Anderson DC, Payan DG: Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization. Biochemistry. 1996 May 28;35(21):6706-14. [Article]
  3. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
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  5. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [Article]
  6. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
  7. O'Farrell PA, Gonzalez F, Zheng W, Johnston SA, Joshua-Tor L: Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease. Structure. 1999 Jun 15;7(6):619-27. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00290Bleomycinapproved, investigationalunknownsubstrateDetails