Inter-alpha-trypsin inhibitor heavy chain H4
Details
- Name
- Inter-alpha-trypsin inhibitor heavy chain H4
- Synonyms
- Gp120
- IHRP
- Inter-alpha-trypsin inhibitor family heavy chain-related protein
- ITI heavy chain H4
- ITIHL1
- PK-120
- PK120
- Plasma kallikrein sensitive glycoprotein 120
- Gene Name
- ITIH4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049874|Inter-alpha-trypsin inhibitor heavy chain H4 MKPPRPVRTCSKVLVLLSLLAIHQTTTAEKNGIDIYSLTVDSRVSSRFAHTVVTSRVVNR ANTVQEATFQMELPKKAFITNFSMIIDGMTYPGIIKEKAEAQAQYSAAVAKGKSAGLVKA TGRNMEQFQVSVSVAPNAKITFELVYEELLKRRLGVYELLLKVRPQQLVKHLQMDIHIFE PQGISFLETESTFMTNQLVDALTTWQNKTKAHIRFKPTLSQQQKSPEQQETVLDGNLIIR YDVDRAISGGSIQIENGYFVHYFAPEGLTTMPKNVVFVIDKSGSMSGRKIQQTREALIKI LDDLSPRDQFNLIVFSTEATQWRPSLVPASAENVNKARSFAAGIQALGGTNINDAMLMAV QLLDSSNQEERLPEGSVSLIILLTDGDPTVGETNPRSIQNNVREAVSGRYSLFCLGFGFD VSYAFLEKLALDNGGLARRIHEDSDSALQLQDFYQEVANPLLTAVTFEYPSNAVEEVTQN NFRLLFKGSEMVVAGKLQDRGPDVLTATVSGKLPTQNITFQTESSVAEQEAEFQSPKYIF HNFMERLWAYLTIQQLLEQTVSASDADQQALRNQALNLSLAYSFVTPLTSMVVTKPDDQE QSQVAEKPMEGESRNRNVHSGSTFFKYYLQGAKIPKPEASFSPRRGWNRQAGAAGSRMNF RPGVLSSRQLGLPGPPDVPDHAAYHPFRRLAILPASAPPATSNPDPAVSRVMNMKIEETT MTTQTPAPIQAPSAILPLPGQSVERLCVDPRHRQGPVNLLSDPEQGVEVTGQYEREKAGF SWIEVTFKNPLVWVHASPEHVVVTRNRRSSAYKWKETLFSVMPGLKMTMDKTGLLLLSDP DKVTIGLLFWDGRGEGLRLLLRDTDRFSSHVGGTLGQFYQEVLWGSPAASDDGRRTLRVQ GNDHSATRERRLDYQEGPPGVEISCWSVEL
- Number of residues
- 930
- Molecular Weight
- 103356.645
- Theoretical pI
- Not Available
- GO Classification
- Functionsendopeptidase inhibitor activity / serine-type endopeptidase inhibitor activityProcessesacute-phase response / hyaluronan metabolic process / platelet degranulation / response to cytokineComponentsblood microparticle / extracellular exosome / extracellular region / plasma membrane / platelet dense granule lumen
- General Function
- Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration.
- Specific Function
- Endopeptidase inhibitor activity
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0049875|Inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) ATGAAGCCCCCAAGGCCTGTCCGTACCTGCAGCAAAGTTCTCGTCCTGCTTTCACTGCTG GCCATCCACCAGACTACTACTGCCGAAAAGAATGGCATCGACATCTACAGCCTCACCGTG GACTCCAGGGTCTCATCCCGATTTGCCCACACGGTCGTCACCAGCCGAGTGGTCAATAGG GCCAATACTGTGCAGGAGGCCACCTTCCAGATGGAGCTGCCCAAGAAAGCCTTCATCACC AACTTCTCCATGATCATCGATGGCATGACCTACCCAGGGATCATCAAGGAGAAGGCTGAA GCCCAGGCACAGTACAGCGCAGCAGTGGCCAAGGGAAAGAGCGCTGGCCTCGTCAAGGCC ACCGGGAGAAACATGGAGCAGTTCCAGGTGTCGGTCAGTGTGGCTCCCAATGCCAAGATC ACCTTTGAGCTGGTCTATGAGGAGCTGCTCAAGCGGCGTTTGGGGGTGTACGAGCTGCTG CTGAAAGTGCGGCCCCAGCAGCTGGTCAAGCACCTGCAGATGGACATTCACATCTTCGAG CCCCAGGGCATCAGCTTTCTGGAGACAGAGAGCACCTTCATGACCAACCAGCTGGTAGAC GCCCTCACCACCTGGCAGAATAAGACCAAGGCTCACATCCGGTTCAAGCCAACACTTTCC CAGCAGCAAAAGTCCCCAGAGCAGCAAGAAACAGTCCTGGACGGCAACCTCATTATCCGC TATGATGTGGACCGGGCCATCTCCGGGGGCTCCATTCAGATCGAGAACGGCTACTTTGTA CACTACTTTGCCCCCGAGGGCCTAACCACAATGCCCAAGAATGTGGTCTTTGTCATTGAC AAGAGCGGCTCCATGAGTGGCAGGAAAATCCAGCAGACCCGGGAAGCCCTAATCAAGATC CTGGATGACCTCAGCCCCAGAGACCAGTTCAACCTCATCGTCTTCAGTACAGAAGCAACT CAGTGGAGGCCATCACTGGTGCCAGCCTCAGCCGAGAACGTGAACAAGGCCAGGAGCTTT GCTGCGGGCATCCAGGCCCTGGGAGGGACCAACATCAATGATGCAATGCTGATGGCTGTG CAGTTGCTGGACAGCAGCAACCAGGAGGAGCGGCTGCCCGAAGGGAGTGTCTCACTCATC ATCCTGCTCACCGATGGCGACCCCACTGTGGGGGAGACTAACCCCAGGAGCATCCAGAAT AACGTGCGGGAAGCTGTAAGTGGCCGGTACAGCCTCTTCTGCCTGGGCTTCGGTTTCGAC GTCAGCTATGCCTTCCTGGAGAAGCTGGCACTGGACAATGGCGGCCTGGCCCGGCGCATC CATGAGGACTCAGACTCTGCCCTGCAGCTCCAGGACTTCTACCAGGAAGTGGCCAACCCA CTGCTGACAGCAGTGACCTTCGAGTACCCAAGCAATGCCGTGGAGGAGGTCACTCAGAAC AACTTCCGGCTCCTCTTCAAGGGCTCAGAGATGGTGGTGGCTGGGAAGCTCCAGGACCGG GGGCCTGATGTGCTCACAGCCACAGTCAGTGGGAAGCTGCCTACACAGAACATCACTTTC CAAACGGAGTCCAGTGTGGCAGAGCAGGAGGCGGAGTTCCAGAGCCCCAAGTATATCTTC CACAACTTCATGGAGAGGCTCTGGGCATACCTGACTATCCAGCAGCTGCTGGAGCAAACT GTCTCCGCATCCGATGCTGATCAGCAGGCCCTCCGGAACCAAGCGCTGAATTTATCACTT GCCTACAGCTTTGTCACGCCTCTCACATCTATGGTAGTCACCAAACCCGATGACCAAGAG CAGTCTCAAGTTGCTGAGAAGCCCATGGAAGGCGAAAGTAGAAACAGGAATGTCCACTCA GGTTCCACTTTCTTCAAATATTATCTCCAGGGAGCAAAAATACCAAAACCAGAGGCTTCC TTTTCTCCAAGAAGAGGATGGAATAGACAAGCTGGAGCTGCTGGCTCCCGGATGAATTTC AGACCTGGGGTTCTCAGCTCCAGGCAACTTGGACTCCCAGGACCTCCTGATGTTCCTGAC CATGCTGCTTACCACCCCTTCCGCCGTCTGGCCATCTTGCCTGCTTCAGCACCACCAGCC ACCTCAAATCCTGATCCAGCTGTGTCTCGTGTCATGAATATGAAAATCGAAGAAACAACC ATGACAACCCAAACCCCAGCCCCCATACAGGCTCCCTCTGCCATCCTGCCACTGCCTGGG CAGAGTGTGGAGCGGCTCTGTGTGGACCCCAGACACCGCCAGGGGCCAGTGAACCTGCTC TCAGACCCTGAGCAAGGGGTTGAGGTGACTGGCCAGTATGAGAGGGAGAAGGCTGGGTTC TCATGGATCGAAGTGACCTTCAAGAACCCCCTGGTATGGGTTCACGCATCCCCTGAACAC GTGGTGGTGACTCGGAACCGAAGAAGCTCTGCGTACAAGTGGAAGGAGACGCTATTCTCA GTGATGCCCGGCCTGAAGATGACCATGGACAAGACGGGTCTCCTGCTGCTCAGTGACCCA GACAAAGTGACCATCGGCCTGTTGTTCTGGGATGGCCGTGGGGAGGGGCTCCGGCTCCTT CTGCGTGACACTGACCGCTTCTCCAGCCACGTTGGAGGGACCCTTGGCCAGTTTTACCAG GAGGTGCTCTGGGGATCTCCAGCAGCATCAGATGACGGCAGACGCACGCTGAGGGTTCAG GGCAATGACCACTCTGCCACCAGAGAGCGCAGGCTGGATTACCAGGAGGGGCCCCCGGGA GTGGAGATTTCCTGCTGGTCTGTGGAGCTGTAG
- Chromosome Location
- 3
- Locus
- 3p21.1
- External Identifiers
Resource Link UniProtKB ID Q14624 UniProtKB Entry Name ITIH4_HUMAN HGNC ID HGNC:6169 - General References
- Nishimura H, Kakizaki I, Muta T, Sasaki N, Pu PX, Yamashita T, Nagasawa S: cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein. FEBS Lett. 1995 Jan 3;357(2):207-11. [Article]
- Saguchi K, Tobe T, Hashimoto K, Sano Y, Nakano Y, Miura NH, Tomita M: Cloning and characterization of cDNA for inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP), a novel human plasma glycoprotein. J Biochem. 1995 Jan;117(1):14-8. [Article]
- Saguchi K, Tobe T, Hashimoto K, Nagasaki Y, Oda E, Nakano Y, Miura NH, Tomita M: Isolation and characterization of the human inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene (ITIHL1). J Biochem. 1996 May;119(5):898-905. [Article]
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- Choi-Miura NH, Sano Y, Oda E, Nakano Y, Tobe T, Yanagishita T, Taniyama M, Katagiri T, Tomita M: Purification and characterization of a novel glycoprotein which has significant homology to heavy chains of inter-alpha-trypsin inhibitor family from human plasma. J Biochem. 1995 Feb;117(2):400-7. [Article]
- Pu XP, Iwamoto A, Nishimura H, Nagasawa S: Purification and characterization of a novel substrate for plasma kallikrein (PK-120) in human plasma. Biochim Biophys Acta. 1994 Oct 19;1208(2):338-43. [Article]
- Pineiro M, Alava MA, Gonzalez-Ramon N, Osada J, Lasierra P, Larrad L, Pineiro A, Lampreave F: ITIH4 serum concentration increases during acute-phase processes in human patients and is up-regulated by interleukin-6 in hepatocarcinoma HepG2 cells. Biochem Biophys Res Commun. 1999 Sep 16;263(1):224-9. [Article]
- Zhang H, Li XJ, Martin DB, Aebersold R: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. Nat Biotechnol. 2003 Jun;21(6):660-6. Epub 2003 May 18. [Article]
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- Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61. doi: 10.1021/pr8008012. [Article]
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- Tozaki T, Choi-Miura NH, Taniyama M, Kurosawa M, Tomita M: SNP analysis of the inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene by a fluorescence-adapted SSCP method. BMC Med Genet. 2002 Jul 29;3:6. Epub 2002 Jul 29. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01593 Zinc approved, investigational unknown Details DB14487 Zinc acetate approved, investigational unknown Details DB14533 Zinc chloride approved, investigational unknown binder Details DB14548 Zinc sulfate, unspecified form approved, experimental unknown binder Details