Ephrin type-A receptor 7

Details

Name
Ephrin type-A receptor 7
Synonyms
  • 2.7.10.1
  • EHK-3
  • EHK3
  • EK11
  • EPH homology kinase 3
  • EPH-like kinase 11
  • HEK11
Gene Name
EPHA7
Organism
Humans
Amino acid sequence
>lcl|BSEQ0007883|Ephrin type-A receptor 7
MVFQTRYPSWIILCYIWLLRFAHTGEAQAAKEVLLLDSKAQQTELEWISSPPNGWEEISG
LDENYTPIRTYQVCQVMEPNQNNWLRTNWISKGNAQRIFVELKFTLRDCNSLPGVLGTCK
ETFNLYYYETDYDTGRNIRENLYVKIDTIAADESFTQGDLGERKMKLNTEVREIGPLSKK
GFYLAFQDVGACIALVSVKVYYKKCWSIIENLAIFPDTVTGSEFSSLVEVRGTCVSSAEE
EAENAPRMHCSAEGEWLVPIGKCICKAGYQQKGDTCEPCGRGFYKSSSQDLQCSRCPTHS
FSDKEGSSRCECEDGYYRAPSDPPYVACTRPPSAPQNLIFNINQTTVSLEWSPPADNGGR
NDVTYRILCKRCSWEQGECVPCGSNIGYMPQQTGLEDNYVTVMDLLAHANYTFEVEAVNG
VSDLSRSQRLFAAVSITTGQAAPSQVSGVMKERVLQRSVELSWQEPEHPNGVITEYEIKY
YEKDQRERTYSTVKTKSTSASINNLKPGTVYVFQIRAFTAAGYGNYSPRLDVATLEEATG
KMFEATAVSSEQNPVIIIAVVAVAGTIILVFMVFGFIIGRRHCGYSKADQEGDEELYFHF
KFPGTKTYIDPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDV
AVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALD
AFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLS
RVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDM
SNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQIVGILDKMIRNPNSL
KTPLGTCSRPISPLLDQNTPDFTTFCSVGEWLQAIKMERYKDNFTAAGYNSLESVARMTI
EDVMSLGITLVGHQKKIMSSIQTMRAQMLHLHGTGIQV
Number of residues
998
Molecular Weight
112095.765
Theoretical pI
5.55
GO Classification
Functions
ATP binding / axon guidance receptor activity / chemorepellent activity / GPI-linked ephrin receptor activity / protein tyrosine kinase activity
Processes
axon guidance / brain development / branching morphogenesis of a nerve / collateral sprouting / ephrin receptor signaling pathway / negative chemotaxis / negative regulation of collateral sprouting / negative regulation of phosphatidylinositol 3-kinase signaling / negative regulation of synapse assembly / nephric duct morphogenesis / peptidyl-tyrosine phosphorylation / phosphorylation / positive regulation of neuron apoptotic process / regulation of cell-cell adhesion / regulation of cysteine-type endopeptidase activity involved in apoptotic process / regulation of ERK1 and ERK2 cascade / regulation of peptidyl-tyrosine phosphorylation / regulation of protein autophosphorylation / retinal ganglion cell axon guidance
Components
dendrite / integral component of plasma membrane / neuromuscular junction / neuronal cell body / plasma membrane / postsynaptic membrane
General Function
Protein tyrosine kinase activity
Specific Function
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.
Pfam Domain Function
Transmembrane Regions
556-576
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0021382|Ephrin type-A receptor 7 (EPHA7)
ATGGTTTTTCAAACTCGGTACCCTTCATGGATTATTTTATGCTACATCTGGCTGCTCCGC
TTTGCACACACAGGGGAGGCGCAGGCTGCGAAGGAAGTACTACTGCTGGATTCTAAAGCA
CAACAAACAGAGTTGGAGTGGATTTCCTCTCCACCCAATGGGTGGGAAGAAATTAGTGGT
TTGGATGAGAACTATACCCCGATACGAACATACCAGGTGTGCCAAGTCATGGAGCCCAAC
CAAAACAACTGGCTGCGGACTAACTGGATTTCCAAAGGCAATGCACAAAGGATTTTTGTA
GAATTGAAATTCACCCTGAGGGATTGTAACAGTCTTCCTGGAGTACTGGGAACTTGCAAG
GAAACATTTAATTTGTACTATTATGAAACAGACTATGACACTGGCAGGAATATAAGAGAA
AACCTCTATGTAAAAATAGACACCATTGCTGCAGATGAAAGTTTTACCCAAGGTGACCTT
GGTGAAAGAAAGATGAAGCTTAACACTGAGGTGAGAGAGATTGGACCTTTGTCCAAAAAG
GGATTCTATCTTGCCTTTCAGGATGTAGGGGCTTGCATAGCTTTGGTTTCTGTCAAAGTG
TACTACAAGAAGTGCTGGTCCATTATTGAGAACTTAGCTATCTTTCCAGATACAGTGACT
GGTTCAGAATTTTCCTCTTTAGTCGAGGTTCGAGGGACATGTGTCAGCAGTGCAGAGGAA
GAAGCGGAAAACGCCCCCAGGATGCACTGCAGTGCAGAAGGAGAATGGTTAGTGCCCATT
GGAAAATGTATCTGCAAAGCAGGCTACCAGCAAAAAGGAGACACTTGTGAACCCTGTGGC
CGTGGGTTCTACAAGTCTTCCTCTCAAGATCTTCAGTGCTCTCGTTGTCCAACTCACAGT
TTTTCTGATAAAGAAGGCTCCTCCAGATGTGAATGTGAAGATGGGTATTACAGGGCTCCA
TCTGACCCACCATACGTTGCGTGCACAAGGCCTCCATCTGCACCACAGAACCTCATTTTC
AACATCAACCAAACCACAGTAAGTTTGGAATGGAGTCCTCCTGCAGACAATGGGGGAAGA
AACGATGTGACCTACAGAATATTGTGTAAGCGGTGCAGTTGGGAGCAGGGCGAATGTGTT
CCCTGTGGGAGTAACATTGGATACATGCCCCAGCAGACTGGATTAGAGGATAACTATGTC
ACTGTCATGGACCTGCTAGCCCACGCTAATTATACTTTTGAAGTTGAAGCTGTAAATGGA
GTTTCTGACTTAAGCCGATCCCAGAGGCTCTTTGCTGCTGTCAGTATCACCACTGGTCAA
GCAGCTCCCTCGCAAGTGAGTGGAGTAATGAAGGAGAGAGTACTGCAGCGGAGTGTCGAG
CTTTCCTGGCAGGAACCAGAGCATCCCAATGGAGTCATCACAGAATATGAAATCAAGTAT
TACGAGAAAGATCAAAGGGAACGGACCTACTCAACAGTAAAAACCAAGTCTACTTCAGCC
TCCATTAATAATCTGAAACCAGGAACAGTGTATGTTTTCCAGATTCGGGCTTTTACTGCT
GCTGGTTATGGAAATTACAGTCCCAGACTTGATGTTGCTACACTAGAGGAAGCTACAGCT
ACAGCTGTCTCCAGTGAACAGAATCCTGTTATTATCATTGCTGTGGTTGCTGTAGCTGGG
ACCATCATTTTGGTGTTCATGGTCTTTGGCTTCATCATTGGGAGAAGGCACTGTGGTTAT
AGCAAAGCTGACCAAGAAGGCGATGAAGAGCTTTACTTTCATTTTAAATTTCCAGGCACC
AAAACCTACATTGACCCTGAAACCTATGAGGACCCAAATAGAGCTGTCCATCAATTCGCC
AAGGAGCTAGATGCCTCCTGTATTAAAATTGAGCGTGTGATTGGTGCAGGAGAATTCGGT
GAAGTCTGCAGTGGCCGTTTGAAACTTCCAGGGAAAAGAGATGTTGCAGTAGCCATAAAA
ACCCTGAAAGTTGGTTACACAGAAAAACAAAGGAGAGACTTTTTGTGTGAAGCAAGCATC
ATGGGGCAGTTTGACCACCCGAATGTTGTCCATTTGGAAGGGGTTGTTACAAGAGGGAAA
CCAGTCATGATAGTAATAGAGTTCATGGAAAATGGAGCCCTAGATGCATTTCTCAGGAAA
CATGATGGGCAATTTACAGTCATTCAGTTAGTAGGAATGCTGAGAGGAATTGCTGCTGGA
ATGAGATATTTGGCTGATATGGGATATGTTCACAGGGACCTTGCAGCTCGCAATATTCTT
GTCAACAGCAATCTCGTTTGTAAAGTGTCAGATTTTGGCCTGTCCCGAGTTATAGAGGAT
GATCCAGAAGCTGTCTATACAACTACTGGTGGAAAAATTCCAGTAAGGTGGACAGCACCC
GAAGCCATCCAGTACCGGAAATTCACATCAGCCAGTGATGTATGGAGCTATGGAATAGTC
ATGTGGGAAGTTATGTCTTATGGAGAAAGACCTTATTGGGACATGTCAAATCAAGATGTT
ATAAAAGCAATAGAAGAAGGTTATCGTTTACCAGCACCCATGGACTGCCCAGCTGGCCTT
CACCAGCTAATGTTGGATTGTTGGCAAAAGGAGCGTGCTGAAAGGCCAAAATTTGAACAG
ATAGTTGGAATTCTAGACAAAATGATTCGAAACCCAAATAGTCTGAAAACTCCCCTGGGA
ACTTGTAGTAGGCCAATAAGCCCTCTTCTGGATCAAAACACTCCTGATTTCACTACCTTT
TGTTCAGTTGGAGAATGGCTACAAGCTATTAAGATGGAAAGATATAAAGATAATTTCACG
GCAGCTGGCTACAATTCCCTTGAATCAGTAGCCAGGATGACTATTGAGGATGTGATGAGT
TTAGGGATCACACTGGTTGGTCATCAAAAGAAAATCATGAGCAGCATTCAGACTATGAGA
GCACAAATGCTACATTTACATGGAACTGGCATTCAAGTGTGA
Chromosome Location
6
Locus
6q16.1
External Identifiers
ResourceLink
UniProtKB IDQ15375
UniProtKB Entry NameEPHA7_HUMAN
GenBank Protein ID551608
GenBank Gene IDL36642
HGNC IDHGNC:3390
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB079705-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamideexperimentalunknownDetails
DB12010Fostamatinibapproved, investigationalunknowninhibitorDetails