Splicing factor 3A subunit 2
Details
- Name
- Splicing factor 3A subunit 2
- Synonyms
- SAP 62
- SAP62
- SF3a66
- Spliceosome-associated protein 62
- Gene Name
- SF3A2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049648|Splicing factor 3A subunit 2 MDFQHRPGGKTGSGGVASSSESNRDRRERLRQLALETIDINKDPYFMKNHLGSYECKLCL TLHNNEGSYLAHTQGKKHQTNLARRAAKEAKEAPAQPAPEKVKVEVKKFVKIGRPGYKVT KQRDSEMGQQSLLFQIDYPEIAEGIMPRHRFMSAYEQRIEPPDRRWQYLLMAAEPYETIA FKVPSREIDKAEGKFWTHWNRETKQFFLQFHFKMEKPPAPPSLPAGPPGVKRPPPPLMNG LPPRPPLPESLPPPPPGGLPLPPMPPTGPAPSGPPGPPQLPPPAPGVHPPAPVVHPPASG VHPPAPGVHPPAPGVHPPAPGVHPPTSGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPP APGVHPPPSAGVHPQAPGVHPAAPAVHPQAPGVHPPAPGMHPQAPGVHPQPPGVHPSAPG VHPQPPGVHPSNPGVHPPTPMPPMLRPPLPSEGPGNIPPPPPTN
- Number of residues
- 464
- Molecular Weight
- 49255.355
- Theoretical pI
- Not Available
- GO Classification
- FunctionsRNA binding / zinc ion bindingProcessesmRNA 3'-splice site recognition / mRNA processing / mRNA splicing, via spliceosome / positive regulation of neuron projection development / RNA splicingComponentscatalytic step 2 spliceosome / nuclear speck / nucleoplasm / small nuclear ribonucleoprotein complex / spliceosomal complex / U2 snRNP / U2-type prespliceosome
- General Function
- Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.
- Specific Function
- Rna binding
- Pfam Domain Function
- SF3A2 (PF16835)
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0049649|Splicing factor 3A subunit 2 (SF3A2) ATGGACTTCCAGCATCGCCCCGGGGGCAAGACCGGGAGCGGGGGCGTGGCCTCCTCCTCC GAGAGCAACCGTGACCGCAGGGAGCGCCTCCGGCAGCTGGCCCTGGAGACCATCGACATC AACAAGGACCCGTACTTCATGAAGAACCACCTGGGCTCCTATGAATGCAAACTCTGCCTG ACACTTCACAACAATGAGGGGAGCTACCTGGCACATACGCAGGGGAAGAAGCACCAGACC AACCTGGCCCGGCGAGCAGCCAAGGAGGCCAAGGAGGCCCCTGCCCAGCCCGCGCCTGAG AAGGTCAAGGTGGAGGTGAAGAAGTTTGTGAAGATCGGCCGCCCGGGCTACAAAGTGACC AAGCAGAGAGACTCGGAGATGGGCCAGCAGAGCCTCCTCTTCCAGATTGACTACCCTGAG ATCGCCGAGGGCATCATGCCACGTCACCGCTTCATGTCTGCGTACGAGCAGAGGATCGAG CCTCCGGACCGGCGCTGGCAGTACCTGCTCATGGCCGCCGAGCCCTACGAGACCATTGCC TTCAAGGTGCCGAGCAGAGAGATCGACAAGGCGGAGGGCAAGTTCTGGACACACTGGAAC CGGGAGACCAAGCAGTTCTTCCTCCAGTTCCACTTTAAGATGGAGAAGCCCCCGGCTCCA CCCAGCCTCCCTGCTGGCCCCCCTGGGGTGAAGCGGCCTCCACCCCCGCTGATGAACGGT CTGCCCCCTCGGCCACCGCTGCCTGAGTCTTTGCCACCGCCCCCGCCAGGAGGCCTGCCT CTGCCACCCATGCCCCCCACAGGGCCTGCGCCCTCAGGGCCCCCGGGACCACCCCAGCTA CCCCCGCCAGCTCCAGGGGTCCACCCCCCGGCCCCAGTGGTGCATCCCCCTGCATCTGGG GTCCATCCCCCAGCTCCTGGCGTCCACCCCCCAGCTCCTGGCGTCCATCCCCCAGCCCCT GGGGTCCACCCACCAACCTCTGGGGTCCACCCCCCAGCTCCTGGAGTCCACCCTCCAGCC CCCGGGGTTCACCCACCAGCCCCCGGAGTCCACCCACCAGCCCCTGGGGTTCACCCACCA GCCCCAGGGGTCCATCCTCCCCCATCAGCGGGGGTTCACCCCCAGGCCCCGGGGGTGCAC CCAGCAGCCCCCGCCGTTCACCCTCAGGCCCCAGGGGTGCACCCACCAGCCCCAGGGATG CACCCTCAGGCCCCGGGGGTCCACCCCCAACCTCCCGGGGTCCATCCGTCGGCTCCTGGG GTCCACCCTCAGCCTCCGGGAGTTCACCCCTCAAATCCTGGGGTGCACCCCCCAACTCCC ATGCCCCCAATGCTGAGGCCCCCACTTCCCTCCGAAGGCCCAGGGAACATACCTCCCCCT CCCCCAACCAACTGA
- Chromosome Location
- 19
- Locus
- 19p13.3
- External Identifiers
Resource Link UniProtKB ID Q15428 UniProtKB Entry Name SF3A2_HUMAN HGNC ID HGNC:10766 - General References
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