Regucalcin
Details
- Name
- Regucalcin
- Synonyms
- Gluconolactonase
- GNL
- RC
- Senescence marker protein 30
- SMP-30
- SMP30
- Gene Name
- RGN
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009021|Regucalcin MSSIKIECVLPENCRCGESPVWEEVSNSLLFVDIPAKKVCRWDSFTKQVQRVTMDAPVSS VALRQSGGYVATIGTKFCALNWKEQSAVVLATVDNDKKNNRFNDGKVDPAGRYFAGTMAE ETAPAVLERHQGALYSLFPDHHVKKYFDQVDISNGLDWSLDHKIFYYIDSLSYSVDAFDY DLQTGQISNRRSVYKLEKEEQIPDGMCIDAEGKLWVACYNGGRVIRLDPVTGKRLQTVKL PVDKTTSCCFGGKNYSEMYVTCARDGMDPEGLLRQPEAGGIFKITGLGVKGIAPYSYAG
- Number of residues
- 299
- Molecular Weight
- 33252.53
- Theoretical pI
- Not Available
- GO Classification
- Functionscalcium ion binding / enzyme regulator activity / gluconolactonase activity / zinc ion bindingProcessesaging / cellular calcium ion homeostasis / kidney development / L-ascorbic acid biosynthetic process / liver regeneration / negative regulation of apoptotic process / negative regulation of bone development / negative regulation of calcium-dependent ATPase activity / negative regulation of cyclic-nucleotide phosphodiesterase activity / negative regulation of DNA biosynthetic process / negative regulation of DNA catabolic process / negative regulation of epithelial cell proliferation / negative regulation of GTPase activity / negative regulation of leucine-tRNA ligase activity / negative regulation of nitric oxide biosynthetic process / negative regulation of phosphoprotein phosphatase activity / negative regulation of protein kinase activity / negative regulation of RNA biosynthetic process / negative regulation of sperm motility / positive regulation of ATPase activity / positive regulation of calcium-transporting ATPase activity / positive regulation of dUTP diphosphatase activity / positive regulation of fatty acid biosynthetic process / positive regulation of glucose metabolic process / positive regulation of GTPase activity / positive regulation of phosphatase activity / positive regulation of proteolysis involved in cellular protein catabolic process / positive regulation of superoxide dismutase activity / positive regulation of triglyceride biosynthetic process / regulation of calcium-mediated signaling / spermatogenesisComponentscytoplasm / cytosol / nucleoplasm / nucleus
- General Function
- Zinc ion binding
- Specific Function
- Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).
- Pfam Domain Function
- SGL (PF08450)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0013568|Regucalcin (RGN) ATGGATGCCCCAGTCAGCTCCGTGGCTCTTCGCCAGTCGGGAGGCTATGTTGCCACCATT GGAACAAAGTTCTGTGCTTTGAACTGGAAAGAACAATCAGCAGTTGTCTTGGCCACGGTG GATAACGACAAGAAAAACAATCGCTTCAATGATGGGAAGGTGGATCCCGCCGGGAGGTAC TTTGCTGGCACCATGGCTGAGGAAACAGCTCCAGCAGTTCTTGAGCGGCACCAGGGGGCC CTGTACTCCCTCTTTCCTGATCACCACGTGAAAAAGTACTTTGACCAGGTGGACATTTCC AATGGTTTGGATTGGTCGCTAGACCACAAAATCTTCTATTACATTGACAGCCTGTCCTAC TCCGTGGATGCCTTTGACTATGACCTGCAGACAGGACAGATCTCCAACCGCAGAAGTGTT TACAAGCTAGAAAAGGAAGAACAAATCCCAGATGGAATGTGTATTGATGCTGAGGGGAAG CTCTGGGTGGCCTGTTACAATGGAGGAAGAGTGATTCGTTTAGATCCTGTGACAGGGAAA AGACTTCAAACTGTGAAGTTGCCTGTTGATAAAACAACTTCATGCTGCTTTGGAGGGAAG AATTACTCTGAAATGTATGTGACCTGCGCCCGGGATGGGATGGACCCCGAGGGTCTTTTG AGGCAACCTGAAGCTGGTGGAATTTTCAAGATAACTGGTCTGGGGGTCAAAGGAATTGCT CCCTACTCCTATGCGGGATGA
- Chromosome Location
- X
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q15493 UniProtKB Entry Name RGN_HUMAN HGNC ID HGNC:9989 - General References
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