V-type proton ATPase subunit S1

Details

Name

V-type proton ATPase subunit S1

Synonyms

• ATP6IP1
• ATP6S1
• Protein XAP-3
• V-ATPase Ac45 subunit
• V-ATPase S1 accessory protein
• V-ATPase subunit S1
• Vacuolar proton pump subunit S1
• VATPS1
• XAP3

Gene Name

ATP6AP1

Organism

Humans

Amino acid sequence

>lcl|BSEQ0052423|V-type proton ATPase subunit S1
MMAAMATARVRMGPRCAQALWRMPWLPVFLSLAAAAAAAAAEQQVPLVLWSSDRDLWAPA
ADTHEGHITSDLQLSTYLDPALELGPRNVLLFLQDKLSIEDFTAYGGVFGNKQDSAFSNL
ENALDLAPSSLVLPAVDWYAVSTLTTYLQEKLGASPLHVDLATLRELKLNASLPALLLIR
LPYTASSGLMAPREVLTGNDEVIGQVLSTLKSEDVPYTAALTAVRPSRVARDVAVVAGGL
GRQLLQKQPVSPVIHPPVSYNDTAPRILFWAQNFSVAYKDQWEDLTPLTFGVQELNLTGS
FWNDSFARLSLTYERLFGTTVTFKFILANRLYPVSARHWFTMERLEVHSNGSVAYFNASQ
VTGPSIYSFHCEYVSSLSKKGSLLVARTQPSPWQMMLQDFQIQAFNVMGEQFSYASDCAS
FFSPGIWMGLLTSLFMLFIFTYGLHMILSLKTMDRFDDHKGPTISLTQIV

Number of residues

470

Molecular Weight

52025.255

Theoretical pI

Not Available

GO Classification

Functions

ATP binding / proton-transporting ATP synthase activity, rotational mechanism / proton-transporting ATPase activity, rotational mechanism / Rab GTPase binding

Processes

cellular iron ion homeostasis / cellular response to increased oxygen levels / establishment of organelle localization / insulin receptor signaling pathway / ion transmembrane transport / pH reduction / positive regulation of bone resorption / positive regulation of ERK1 and ERK2 cascade / positive regulation of exocytosis / positive regulation of osteoblast differentiation / positive regulation of osteoclast development / proton transmembrane transport / regulation of cellular pH / transferrin transport

Components

cell / endoplasmic reticulum membrane / endoplasmic reticulum-Golgi intermediate compartment membrane / endosome membrane / extracellular exosome / integral component of membrane / plasma membrane proton-transporting V-type ATPase complex / proton-transporting two-sector ATPase complex / proton-transporting V-type ATPase, V1 domain

General Function

Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles. Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity. Involved in membrane trafficking and Ca(2+)-dependent membrane fusion. May play a role in the assembly of the V-type ATPase complex. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633).

Specific Function

Atp binding

Pfam Domain Function

• ATP-synt_S1 (PF05827)

Transmembrane Regions

420-440

Cellular Location

Endoplasmic reticulum membrane

Gene sequence

>lcl|BSEQ0052424|V-type proton ATPase subunit S1 (ATP6AP1)
ATGATGGCGGCCATGGCGACGGCTCGAGTGCGGATGGGGCCGCGGTGCGCCCAGGCGCTC
TGGCGCATGCCGTGGCTGCCGGTGTTTTTGTCGTTGGCGGCGGCGGCGGCGGCGGCAGCG
GCGGAGCAGCAGGTCCCGCTGGTGCTGTGGTCGAGTGACCGGGACTTGTGGGCTCCTGCG
GCCGACACTCATGAAGGCCACATCACCAGCGACTTGCAGCTCTCTACCTACTTAGATCCC
GCCCTGGAGCTGGGTCCCAGGAATGTGCTGCTGTTCCTGCAGGACAAGCTGAGCATTGAG
GATTTCACAGCATATGGCGGTGTGTTTGGAAACAAGCAGGACAGCGCCTTTTCTAACCTA
GAGAATGCCCTGGACCTGGCCCCCTCCTCACTGGTGCTTCCTGCCGTCGACTGGTATGCA
GTCAGCACTCTGACCACTTACCTGCAGGAGAAGCTCGGGGCCAGCCCCTTGCATGTGGAC
CTGGCCACCCTGCGGGAGCTGAAGCTCAATGCCAGCCTCCCTGCTCTGCTGCTCATTCGC
CTGCCCTACACAGCCAGCTCTGGTCTGATGGCACCCAGGGAAGTCCTCACAGGCAACGAT
GAGGTCATCGGGCAGGTCCTGAGCACACTCAAGTCCGAAGATGTCCCATACACAGCGGCC
CTCACAGCGGTCCGCCCTTCCAGGGTGGCCCGTGATGTAGCCGTGGTGGCCGGAGGGCTA
GGTCGCCAGCTGCTACAAAAACAGCCAGTATCACCTGTGATCCATCCTCCTGTGAGTTAC
AATGACACCGCTCCCCGGATCCTGTTCTGGGCCCAAAACTTCTCTGTGGCGTACAAGGAC
CAGTGGGAGGACCTGACTCCCCTCACCTTTGGGGTGCAGGAACTCAACCTGACTGGCTCC
TTCTGGAATGACTCCTTTGCCAGGCTCTCACTGACCTATGAACGACTCTTTGGTACCACA
GTGACATTCAAGTTCATTCTGGCCAACCGCCTCTACCCAGTGTCTGCCCGGCACTGGTTT
ACCATGGAGCGCCTCGAAGTCCACAGCAATGGCTCCGTCGCCTACTTCAATGCTTCCCAG
GTCACAGGGCCCAGCATCTACTCCTTCCACTGCGAGTATGTCAGCAGCCTGAGCAAGAAG
GGTAGTCTCCTCGTGGCCCGCACGCAGCCCTCTCCCTGGCAGATGATGCTTCAGGACTTC
CAGATCCAGGCTTTCAACGTAATGGGGGAGCAGTTCTCCTACGCCAGCGACTGTGCCAGC
TTCTTCTCCCCCGGCATCTGGATGGGGCTGCTCACCTCCCTGTTCATGCTCTTCATCTTC
ACCTATGGCCTGCACATGATCCTCAGCCTCAAGACCATGGATCGCTTTGATGACCACAAG
GGCCCCACTATTTCTTTGACCCAGATTGTGTGA

Chromosome Location

X

Locus

Xq28

External Identifiers

Resource	Link
UniProtKB ID	Q15904
UniProtKB Entry Name	VAS1_HUMAN
HGNC ID	HGNC:868

General References

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Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB01133	Tiludronic acid	approved, investigational, vet_approved	unknown	inhibitor	Details