NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

Details

Name
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
Synonyms
  • CI-13kD-B
  • Complex I subunit B13
  • Complex I-13kD-B
  • NADH-ubiquinone oxidoreductase 13 kDa-B subunit
Gene Name
NDUFA5
Organism
Humans
Amino acid sequence
>lcl|BSEQ0037025|NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
MAGVLKKTTGLVGLAVCNTPHERLRILYTKILDVLEEIPKNAAYRKYTEQITNEKLAMVK
AEPDVKKLEDQLQGGQLEEVILQAEHELNLARKMREWKLWEPLVEEPPADQWKWPI
Number of residues
116
Molecular Weight
13458.605
Theoretical pI
5.81
GO Classification
Functions
NADH dehydrogenase (ubiquinone) activity
Processes
mitochondrial electron transport, NADH to ubiquinone
Components
mitochondrial respiratory chain complex I
General Function
Nadh dehydrogenase (ubiquinone) activity
Specific Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Mitochondrion inner membrane
Gene sequence
>lcl|BSEQ0016102|NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (NDUFA5)
ATGGCGGGTGTGCTGAAGAAGAGGCTAAGAATATTGTACACAAAGATTCTTGATGTTCTT
GAGGAAATCCCTAAAAATGCAGCATATAGAAAGTATACAGAACAGATTACAAATGAGAAG
CTGGCTATGGTTAAAGCGGAACCAGATGTTAAAAAATTAGAAGACCAACTTCAAGGCGGT
CAATTAGAAGAGGTGATTCTTCAGGCTGAACATGAACTAAATCTGGCAAGAAAAATGAGG
GAATGGAAACTATGGGAGCCATTAGTGGAAGAGCCTCCTGCCGATCAGTGGAAATGGCCA
ATATAA
Chromosome Location
7
Locus
7q32
External Identifiers
ResourceLink
UniProtKB IDQ16718
UniProtKB Entry NameNDUA5_HUMAN
GenBank Protein ID1373173
GenBank Gene IDU53468
GenAtlas IDNDUFA5
HGNC IDHGNC:7688
General References
  1. Pata I, Tensing K, Metspalu A: A human cDNA encoding the homologue of NADH: ubiquinone oxidoreductase subunit B13. Biochim Biophys Acta. 1997 Feb 7;1350(2):115-8. [Article]
  2. Russell MW, du Manoir S, Collins FS, Brody LC: Cloning of the human NADH: ubiquinone oxidoreductase subunit B13: localization to chromosome 7q32 and identification of a pseudogene on 11p15. Mamm Genome. 1997 Jan;8(1):60-1. [Article]
  3. Tensing K, Pata I, Wittig I, Wehnert M, Metspalu A: Genomic organization of the human complex I 13-kDa subunit gene NDUFA5. Cytogenet Cell Genet. 1999;84(1-2):125-7. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00157NADHapproved, nutraceuticalunknownDetails