Hydroxyacylglutathione hydrolase, mitochondrial
Details
- Name
- Hydroxyacylglutathione hydrolase, mitochondrial
- Synonyms
- 3.1.2.6
- GLO2
- Glx II
- Glyoxalase II
- HAGH1
- Gene Name
- HAGH
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037149|Hydroxyacylglutathione hydrolase, mitochondrial MVVGRGLLGRRSLAALGAACARRGLGPALLGVFCHTDLRKNLTVDEGTMKVEVLPALTDN YMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESG LKVYGGDDRIGALTHKITHLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFT GDTLFVAGCGKFYEGTADEMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAA IREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETDPVTTMRAVRREK DQFKMPRD
- Number of residues
- 308
- Molecular Weight
- 33805.645
- Theoretical pI
- 7.36
- GO Classification
- Functionshydroxyacylglutathione hydrolase activity / metal ion bindingProcessescarbohydrate metabolic process / cellular metabolic process / glutathione biosynthetic process / methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione / pyruvate metabolic process / small molecule metabolic processComponentscytoplasm / cytosol / extracellular exosome / mitochondrial matrix
- General Function
- Metal ion binding
- Specific Function
- Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Mitochondrion matrix
- Gene sequence
>lcl|BSEQ0019185|Hydroxyacylglutathione hydrolase, mitochondrial (HAGH) ATGAAGGTAGAGGTGCTGCCTGCCCTGACCGACAACTACATGTACCTGGTCATTGATGAT GAGACCAAGGAGGCTGCCATTGTGGATCCGGTGCAGCCCCAGAAGGTCGTGGACGCGGCG AGAAAGCACGGGGTGAAACTGACCACAGTGCTCACCACCCACCACCACTGGGACCATGCT GGCGGGAATGAGAAACTGGTCAAGCTGGAGTCGGGACTGAAGGTGTACGGGGGTGACGAC CGTATCGGGGCCCTGACTCACAAGATCACTCACCTGTCCACACTGCAGGTGGGGTCTCTG AACGTCAAGTGCCTGGCGACCCCGTGCCACACTTCAGGACACATTTGTTACTTCGTGAGC AAGCCCGGAGGCTCGGAGCCCCCTGCCGTGTTCACAGGTGACACCTTGTTTGTGGCTGGC TGCGGGAAGTTCTATGAAGGGACTGCGGATGAGATGTGTAAAGCTCTGCTGGAGGTCTTG GGCCGGCTCCCCCCGGACACAAGAGTCTACTGTGGCCACGAGTACACCATCAACAACCTC AAGTTTGCACGCCACGTGGAGCCCGGCAATGCCGCCATCCGGGAGAAGCTGGCCTGGGCC AAGGAGAAGTACAGCATCGGGGAGCCCACAGTGCCATCCACCCTGGCAGAGGAGTTTACC TACAACCCCTTCATGAGAGTGAGGGAGAAGACGGTGCAGCAGCACGCAGGTGAGACGGAC CCGGTGACCACCATGCGGGCCGTGCGCAGGGAGAAGGACCAGTTCAAGATGCCCCGGGAC TGA
- Chromosome Location
- 16
- Locus
- 16p13.3
- External Identifiers
Resource Link UniProtKB ID Q16775 UniProtKB Entry Name GLO2_HUMAN GenBank Protein ID 1237213 GenBank Gene ID X90999 GenAtlas ID HAGH HGNC ID HGNC:4805 - General References
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