Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
Details
- Name
- Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
- Synonyms
- 2.7.11.19
- PHK-gamma-M
- PHKG
- Phosphorylase kinase subunit gamma-1
- Serine/threonine-protein kinase PHKG1
- Gene Name
- PHKG1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051902|Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform MTRDEALPDSHSAQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFS PEEVRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKV TLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGER LREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLR MIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQQYLVEEVRHFS PRGKFKVIALTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVK KGQQQNRAALFENTPKAVLLSLAEEDY
- Number of residues
- 387
- Molecular Weight
- 45023.36
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / calmodulin binding / enzyme binding / phosphorylase kinase activity / tau-protein kinase activityProcessescarbohydrate metabolic process / glycogen biosynthetic process / glycogen catabolic process / glycogen metabolic process / intracellular signal transduction / peptidyl-serine phosphorylation / peptidyl-threonine phosphorylationComponentscytosol / phosphorylase kinase complex
- General Function
- Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity).
- Specific Function
- Atp binding
- Pfam Domain Function
- Pkinase (PF00069)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0051903|Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHKG1) ATGACCCGGGACGAGGCACTGCCGGACTCTCATTCTGCACAGGACTTCTATGAGAATTAT GAGCCCAAAGAGATCCTGGGCAGGGGCGTTAGCAGTGTGGTCAGGCGATGCATCCACAAG CCCACGAGCCAGGAGTACGCCGTGAAGGTCATCGACGTCACCGGTGGAGGCAGCTTCAGC CCGGAGGAGGTGCGGGAGCTGCGAGAAGCCACGCTGAAGGAGGTGGACATCCTGCGCAAG GTCTCAGGGCACCCCAACATCATACAGCTGAAGGACACTTATGAGACCAACACTTTCTTC TTCTTGGTGTTTGACCTGATGAAGAGAGGGGAGCTCTTTGACTACCTCACTGAGAAGGTC ACCTTGAGTGAGAAGGAAACCAGAAAGATCATGCGAGCTCTGCTGGAGGTGATCTGCACC TTGCACAAACTCAACATCGTGCACCGGGACCTGAAGCCCGAGAACATTCTCTTGGATGAC AACATGAACATCAAGCTCACAGACTTTGGCTTTTCCTGCCAGCTGGAGCCGGGAGAGAGG CTGCGAGAGGTCTGCGGGACCCCCAGTTACCTGGCCCCTGAGATTATCGAGTGCTCCATG AATGAGGACCACCCGGGCTACGGGAAAGAGGTGGACATGTGGAGCACTGGCGTCATCATG TACACGCTGCTGGCCGGCTCCCCGCCCTTCTGGCACCGGAAGCAGATGCTGATGCTGAGG ATGATCATGAGCGGCAACTACCAGTTTGGCTCGCCCGAGTGGGATGATTACTCGGACACC GTGAAGGACCTGGTCTCCCGATTCCTGGTGGTGCAACCCCAGAACCGCTACACAGCGGAA GAGGCCTTGGCACACCCCTTCTTCCAGCAGTACTTGGTGGAGGAAGTGCGGCACTTCAGC CCCCGGGGGAAGTTCAAGGTGATCGCTCTGACCGTGCTGGCTTCAGTGCGGATCTACTAC CAGTACCGCCGGGTGAAGCCTGTGACCCGGGAGATCGTCATCCGAGACCCCTATGCCCTC CGGCCTCTGCGCCGGCTCATCGACGCCTACGCTTTCCGAATCTATGGCCACTGGGTGAAG AAGGGGCAGCAGCAGAACCGGGCAGCCCTTTTCGAGAACACACCCAAGGCCGTGCTCCTC TCCCTGGCCGAGGAGGACTACTGA
- Chromosome Location
- 7
- Locus
- 7p11.2
- External Identifiers
Resource Link UniProtKB ID Q16816 UniProtKB Entry Name PHKG1_HUMAN HGNC ID HGNC:8930 - General References
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