N5-carboxyaminoimidazole ribonucleotide mutase

Details

Name

N5-carboxyaminoimidazole ribonucleotide mutase

Synonyms

• 5-(carboxyamino)imidazole ribonucleotide mutase
• 5.4.99.18
• N5-CAIR mutase

Gene Name

purE

Organism

Acetobacter aceti

Amino acid sequence

>lcl|BSEQ0012267|N5-carboxyaminoimidazole ribonucleotide mutase
MSETAPLPSASSALEDKAASAPVVGIIMGSQSDWETMRHADALLTELEIPHETLIVSAHR
TPDRLADYARTAAERGLNVIIAGAGGAAHLPGMCAAWTRLPVLGVPVESRALKGMDSLLS
IVQMPGGVPVGTLAIGASGAKNAALLAASILALYNPALAARLETWRALQTASVPNSPITE
DK

Number of residues

182

Molecular Weight

18734.295

Theoretical pI

5.6

GO Classification

Functions

5-(carboxyamino)imidazole ribonucleotide mutase activity

Processes

'de novo' IMP biosynthetic process

General Function

5-(carboxyamino)imidazole ribonucleotide mutase activity

Specific Function

Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

Pfam Domain Function

• AIRC (PF00731)

Transmembrane Regions

Not Available

Cellular Location

Not Available

Gene sequence

>lcl|BSEQ0006346|549 bp
GTGAGCGAAACCGCCCCCCTGCCCTCTGCTTCCAGTGCTTTAGAAGATAAAGCAGCCTCT
GCCCCCGTTGTGGGCATTATCATGGGCAGCCAGTCAGACTGGGAAACCATGCGCCATGCA
GACGCATTGCTGACAGAGCTGGAAATTCCGCATGAAACCCTCATTGTTTCAGCACATCGT
ACGCCAGACCGGTTGGCGGATTATGCGCGTACGGCAGCCGAACGCGGCCTGAATGTGATT
ATTGCTGGGGCCGGTGGAGCTGCACATCTGCCGGGTATGTGTGCGGCATGGACACGCCTG
CCCGTGCTGGGTGTTCCAGTAGAATCTCGCGCTCTTAAAGGCATGGACAGCCTGCTTTCC
ATTGTGCAGATGCCCGGCGGCGTGCCTGTGGGCACTTTGGCTATTGGGGCATCCGGCGCC
AAAAATGCCGCCTTGCTGGCCGCCTCCATTCTTGCACTGTATAACCCGGCCCTTGCCGCA
CGCCTTGAAACATGGCGCGCATTGCAGACGGCCTCTGTCCCCAACTCTCCCATTACCGAA
GATAAATGA

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	Q2QJL3
UniProtKB Entry Name	Q2QJL3_ACEAC
GenBank Gene ID	DQ059549

General References

1. Settembre EC, Chittuluru JR, Mill CP, Kappock TJ, Ealick SE: Acidophilic adaptations in the structure of Acetobacter aceti N5-carboxyaminoimidazole ribonucleotide mutase (PurE). Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1753-60. Epub 2004 Sep 23. [Article]
2. Constantine CZ, Starks CM, Mill CP, Ransome AE, Karpowicz SJ, Francois JA, Goodman RA, Kappock TJ: Biochemical and structural studies of N5-carboxyaminoimidazole ribonucleotide mutase from the acidophilic bacterium Acetobacter aceti. Biochemistry. 2006 Jul 11;45(27):8193-208. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB04272	Citric acid	approved, nutraceutical, vet_approved	unknown		Details