Dihydropteroate synthase type-1

Details

Name
Dihydropteroate synthase type-1
Synonyms
  • 2.5.1.15
  • DHPS
  • Dihydropteroate pyrophosphorylase type I
  • Dihydropteroate synthase type I
  • suf3
Gene Name
sulI
Organism
Mycobacterium fortuitum
Amino acid sequence
>lcl|BSEQ0010168|Dihydropteroate synthase type-1
MLRSRVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDVGPAASHPDARPV
SPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLNDIQGFPDPALYPDIA
EADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSALRRSGVAADRLILDPGM
GFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGATVGLPVKDLGPASLAAELH
AIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGLDHA
Number of residues
283
Molecular Weight
30638.43
Theoretical pI
6.52
GO Classification
Functions
dihydropteroate synthase activity / metal ion binding
Processes
folic acid biosynthetic process / response to antibiotic / tetrahydrofolate biosynthetic process
General Function
Metal ion binding
Specific Function
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives (By similarity). Implicated in resistance to sulfonamide (PubMed:2163027).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0000239|852 bp
ATGTTACGCAGCAGGGTGACGGTGTTCGGCATTCTGAATCTCACCGAGGACTCCTTCTTC
GATGAGAGCCGGCGGCTAGACCCCGCCGGCGCTGTCACCGCGGCGATCGAAATGCTGCGA
GTCGGATCAGACGTCGTGGATGTCGGACCGGCCGCCAGCCATCCGGACGCGAGGCCTGTA
TCGCCGGCCGATGAGATCAGACGTATTGCGCCGCTCTTAGACGCCCTGTCCGATCAGATG
CACCGTGTTTCAATCGACAGCTTCCAACCGGAAACCCAGCGCTATGCGCTCAAGCGCGGC
GTGGGCTACCTGAACGATATCCAAGGATTTCCTGACCCTGCGCTCTATCCCGATATTGCT
GAGGCGGACTGCAGGCTGGTGGTTATGCACTCAGCGCAGCGGGATGGCATCGCCACCCGC
ACCGGTCACCTTCGACCCGAAGACGCGCTCGACGAGATTGTGCGGTTCTTCGAGGCGCGG
GTTTCCGCCTTGCGACGGAGCGGGGTCGCTGCCGACCGGCTCATCCTCGATCCGGGGATG
GGATTTTTCTTGAGCCCCGCACCGGAAACATCGCTGCACGTGCTGTCGAACCTTCAAAAG
CTGAAGTCGGCGTTGGGGCTTCCGCTATTGGTCTCGGTGTCGCGGAAATCCTTCTTGGGC
GCCACCGTTGGCCTTCCTGTAAAGGATCTGGGTCCAGCGAGCCTTGCGGCGGAACTTCAC
GCGATCGGCAATGGCGCTGACTACGTCCGCACCCACGCGCCTGGAGATCTGCGAAGCGCA
ATCACCTTCTCGGAAACCCTCGCGAAATTTCGCAGTCGCGACGCCAGAGACCGAGGGTTA
GATCATGCCTAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ49184
UniProtKB Entry NameDHP1_MYCFO
GenBank Protein ID44284
GenBank Gene IDX53635
General References
  1. Martin C, Timm J, Rauzier J, Gomez-Lus R, Davies J, Gicquel B: Transposition of an antibiotic resistance element in mycobacteria. Nature. 1990 Jun 21;345(6277):739-43. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00891SulfapyridineapprovedunknowninhibitorDetails